CCL21 and CCL27

Data Source: HiPPIP (Novel)

		CCL21	CCL27
Name		C-C motif chemokine ligand 21	C-C motif chemokine ligand 27
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR7 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding	Cytokine Activity Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Chemokine Receptor Binding CXCR Chemokine Receptor Binding
	Biological Process	Establishment Of T Cell Polarity Immunological Synapse Formation Positive Regulation Of Cell-matrix Adhesion Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of T Cell Chemotaxis Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Ruffle Organization Killing Of Cells Of Another Organism Positive Regulation Of Cell Adhesion Mediated By Integrin Mesangial Cell-matrix Adhesion Chemokine (C-C Motif) Ligand 21 Signaling Pathway CCL21-activated CCR7 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade Eosinophil Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Filopodium Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Neutrophil Chemotaxis Dendritic Cell Dendrite Assembly Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Negative Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Chemokine Positive Regulation Of Cell Motility Positive Regulation Of T Cell Migration Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Neutrophil Chemotaxis Killing Of Cells Of Another Organism Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events
GWAS		Autoimmune traits (pleiotropy) ( 30572963 ) Blood protein levels ( 30072576 ) Celiac disease ( 30572963 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Rheumatoid arthritis ( 18794853 23143596 24390342 30423114 30572963 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 )	No GWAS studies recorded
Novel Interactors		5 novel interactors: CCL27 DCTN3 GALT IL11RA RNF38	1 novel interactors: CCL21
Interacting Genes		32 interacting genes: ACKR2 ACKR4 C3orf52 CCL13 CCL17 CCL23 CCL24 CCL26 CCL28 CCL5 CCR7 CTSD CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL17 CXCL2 CXCL9 GOT2 IGFBP7 LRRK1 OTP PF4 PF4V1 PPBP TMEM107 UBQLN4 VCAN XCL1 XCL2	5 interacting genes: ACKR2 CCL11 CCL5 CCR10 PF4V1
Entrez ID		6366	10850
HPRD ID		04113	05321
Ensembl ID		ENSG00000137077	ENSG00000213927
Uniprot IDs		O00585	Q5VZ77 Q9Y4X3
PDB IDs		2L4N 5EKI	2KUM
GO Terms Enriched among Interactors		Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Locomotion Antimicrobial Humoral Response Cytokine Activity Leukocyte Chemotaxis Humoral Immune Response Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Leukocyte Migration Cell Migration Granulocyte Chemotaxis CXCR Chemokine Receptor Binding Cell Motility Killing Of Cells Of Another Organism Granulocyte Migration Inflammatory Response Cell Killing Cytokine-mediated Signaling Pathway Defense Response To Symbiont Immune Response Defense Response To Other Organism Extracellular Space Mononuclear Cell Migration Immune System Process Defense Response Neutrophil Chemotaxis Extracellular Region Response To Other Organism Response To External Biotic Stimulus Neutrophil Migration CXCR3 Chemokine Receptor Binding CCR Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Lymphocyte Chemotaxis Chemokine Receptor Binding Lymphocyte Migration Cell-cell Signaling Signaling Cell Communication Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Regulation Of Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Cell Motility	Cell Chemotaxis Chemokine-mediated Signaling Pathway Chemotaxis Locomotion Chemokine Activity Granulocyte Chemotaxis Granulocyte Migration Cell Migration Eosinophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Eosinophil Migration Cytokine-mediated Signaling Pathway Myeloid Leukocyte Migration Cell Motility Leukocyte Chemotaxis CCR Chemokine Receptor Binding Immune Response Antimicrobial Humoral Response Inflammatory Response Cytokine Activity Leukocyte Migration Humoral Immune Response G Protein-coupled Receptor Signaling Pathway Immune System Process Chemokine Receptor Binding Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Dendritic Cell Chemotaxis Defense Response Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Cell Adhesion Mediated By Integrin Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Dendritic Cell Migration Regulation Of Lymphocyte Chemotaxis Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of T Cell Migration Intracellular Signaling Cassette Positive Regulation Of Lymphocyte Migration Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Actin Filament Polymerization Regulation Of T Cell Migration Regulation Of Granulocyte Chemotaxis ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Apoptotic Process Signal Transduction Response To Other Organism