CCL21 and CCL26

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		CCL21	CCL26
Description		C-C motif chemokine ligand 21	C-C motif chemokine ligand 26
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR7 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding	Cytokine Activity Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding CX3C Chemokine Receptor Binding Receptor Ligand Activity CCR Chemokine Receptor Binding
	Biological Process	Establishment Of T Cell Polarity Immunological Synapse Formation Positive Regulation Of Cell-matrix Adhesion Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of T Cell Chemotaxis Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Ruffle Organization Killing Of Cells Of Another Organism Positive Regulation Of Cell Adhesion Mediated By Integrin Mesangial Cell-matrix Adhesion Chemokine (C-C Motif) Ligand 21 Signaling Pathway CCL21-activated CCR7 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade Eosinophil Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Filopodium Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Neutrophil Chemotaxis Dendritic Cell Dendrite Assembly Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Negative Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Chemokine Positive Regulation Of Cell Motility Positive Regulation Of T Cell Migration Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process	Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling T Cell Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Eosinophil Chemotaxis Positive Regulation Of Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Blood protein levels ( 30072576) Celiac disease ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Rheumatoid arthritis ( 18794853 23143596 24390342 30423114 30572963) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Carotid plaque burden ( 28282560) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Interacting Genes		32 interacting genes: ACKR2 ACKR4 C3orf52 CCL13 CCL17 CCL23 CCL24 CCL26 CCL28 CCL5 CCR7 CTSD CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL17 CXCL2 CXCL9 GOT2 IGFBP7 LRRK1 OTP PF4 PF4V1 PPBP TMEM107 UBQLN4 VCAN XCL1 XCL2	24 interacting genes: APP C3orf52 CCL11 CCL13 CCL17 CCL2 CCL21 CCL28 CCL5 CCL8 CCR1 CCR3 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL9 PAX6 PF4 PF4V1 PPBP XCL1 XCL2
Entrez ID		6366	10344
HPRD ID		04113	05262
Ensembl ID		ENSG00000137077	ENSG00000006606
Uniprot IDs		O00585	Q9Y258
PDB IDs		2L4N 5EKI	1G2S 1G2T
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Locomotion Antimicrobial Humoral Response Cytokine Activity Leukocyte Chemotaxis Humoral Immune Response Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Leukocyte Migration Cell Migration Granulocyte Chemotaxis CXCR Chemokine Receptor Binding Cell Motility Killing Of Cells Of Another Organism Granulocyte Migration Inflammatory Response Cell Killing Cytokine-mediated Signaling Pathway Defense Response To Symbiont Immune Response Defense Response To Other Organism Extracellular Space Mononuclear Cell Migration Immune System Process Defense Response Neutrophil Chemotaxis Extracellular Region Response To Other Organism Response To External Biotic Stimulus Neutrophil Migration CXCR3 Chemokine Receptor Binding CCR Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Lymphocyte Chemotaxis Chemokine Receptor Binding Lymphocyte Migration Cell-cell Signaling Signaling Cell Communication Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Regulation Of Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Cell Motility	Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Locomotion Antimicrobial Humoral Response Leukocyte Chemotaxis Humoral Immune Response Cytokine Activity Chemokine-mediated Signaling Pathway Leukocyte Migration Myeloid Leukocyte Migration Cell Migration Granulocyte Chemotaxis Cell Motility Killing Of Cells Of Another Organism Granulocyte Migration Inflammatory Response Defense Response To Symbiont Cell Killing Defense Response To Other Organism Immune Response Defense Response Immune System Process Cytokine-mediated Signaling Pathway Response To Other Organism Extracellular Space CXCR Chemokine Receptor Binding CCR Chemokine Receptor Binding Response To External Biotic Stimulus Mononuclear Cell Migration G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Leukocyte Migration Extracellular Region Regulation Of Leukocyte Migration Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Response To Stress Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Eosinophil Chemotaxis Regulation Of Cell Migration Positive Regulation Of Locomotion Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Eosinophil Migration Regulation Of Cell Motility Positive Regulation Of Monocyte Chemotaxis Regulation Of Locomotion Positive Regulation Of Calcium Ion Transport
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