SMYD1 and DVL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMYD1	DVL1
Description		SET and MYND domain containing 1	dishevelled segment polarity protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Cytosol Microtubule Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse Neuronal Dense Core Vesicle Wnt Signalosome
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone H3K4 Methyltransferase Activity Metal Ion Binding Histone H3K4 Trimethyltransferase Activity	Frizzled Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Small GTPase Binding Identical Protein Binding
	Biological Process	Chromatin Remodeling Heart Development Positive Regulation Of Myotube Differentiation Methylation Skeletal Muscle Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription	Heart Looping Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Neurotransmitter Secretion Axonogenesis Axon Guidance Neuromuscular Junction Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Synaptic Vesicle Exocytosis Neural Tube Development Convergent Extension Involved In Neural Plate Elongation Cytoplasmic Microtubule Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Protein Localization To Nucleus Social Behavior Protein Localization To Microtubule Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Receptor Clustering Positive Regulation Of Transcription By RNA Polymerase II Collateral Sprouting Axon Extension Dendrite Morphogenesis Synapse Organization Protein Stabilization Convergent Extension Involved In Organogenesis Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Prepulse Inhibition Dendritic Spine Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Cochlea Morphogenesis Presynapse Assembly Postsynapse Organization Regulation Of Postsynapse Organization Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Protein Localization To Presynapse Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Cardiogenesis	TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS		Night sleep phenotypes ( 27126917) Retinal detachment or retinal break ( 31816047)	Inflammatory bowel disease ( 28067908) Nicotine dependence ( 32281736) Ulcerative colitis ( 28067908)
Interacting Genes		45 interacting genes: ARID5A BACH2 BHLHE40 C11orf16 CCDC33 CFAP263 CFAP68 CFTR CIMIP2A DISC1 DVL1 FAM204A FAM83A FAM86C1P H3-5 HDAC2 HDAC3 HDHD3 HMG20A HOMEZ KIF16B KRT35 LENG8 MDFI MEOX2 MYH7B NACA NEFL OGDHL PATZ1 POU2AF2 POU6F2 PRR22 RBM4B RSPH6A RUSC1 SNX11 SPAG8 TBRG1 TTC33 USP54 UTP14A WDR77 ZBTB3 ZBTB44	45 interacting genes: ANXA7 ARRB1 ATN1 AXIN1 BAG3 BRD7 BUB1 CCDC88C CSNK1D CSNK1E CSNK2A1 CTNNB1 CXXC4 DAAM1 DAB2 DVL3 DYNLT1 EPS8 FBXW7 FRAT1 FZD7 GNAI3 HDHD2 HECW1 LRRK2 MLH3 MSH2 NCK2 NEDD4 PPM1A PSMA3 RAC1 RB1 SIPA1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SMYD1 SNCA TRIM69 USP13 VANGL1 VANGL2
Entrez ID		150572	1855
HPRD ID		06025	03220
Ensembl ID		ENSG00000115593	ENSG00000107404
Uniprot IDs		E9PHG3 Q8NB12	O14640
PDB IDs			6LCA 6LCB 6TTK
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Protein Decrotonylase Activity Histone Decrotonylase Activity Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Axonemal A Tubule Inner Sheath Microtubule-based Process Regulation Of Transcription By RNA Polymerase II Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Sperm Flagellum Cilium Movement Involved In Cell Motility Circadian Rhythm Protein Lysine Deacetylase Activity Microtubule-based Movement	Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway I-SMAD Binding Regulation Of Canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Signal Transduction Heteromeric SMAD Protein Complex Regulation Of Protein Catabolic Process Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process SMAD Protein Complex Cytoplasm Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Response To Growth Factor R-SMAD Binding Positive Regulation Of Protein Metabolic Process Embryonic Pattern Specification Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Stability Cellular Response To Growth Factor Stimulus Dorsal/ventral Axis Specification Regulation Of Cellular Component Organization Cytosol Negative Regulation Of Biosynthetic Process
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