GATA4 and NFATC4

Number of citations of the paper that reports this interaction (PMID 9568714)
423

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		GATA4	NFATC4
Gene Name		GATA binding protein 4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
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Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex	Nucleus Transcription Factor Complex Cytoplasm Cytosol Intermediate Filament Cytoskeleton
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Enhancer Sequence-specific DNA Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Activating Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding NFAT Protein Binding Co-SMAD Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Coactivator Activity Protein Binding Transcription Factor Binding Peroxisome Proliferator Activated Receptor Binding
	Biological Process	In Utero Embryonic Development Gastrulation With Mouth Forming Second Endoderm Formation Heart Looping Atrioventricular Valve Formation Endocardial Cushion Development Cardiac Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cell-cell Signaling Spermatogenesis Endoderm Development Blood Coagulation Male Gonad Development Response To Mechanical Stimulus Negative Regulation Of Autophagy Positive Regulation Vascular Endothelial Growth Factor Production Cardiac Muscle Hypertrophy In Response To Stress Signal Transduction Involved In Regulation Of Gene Expression BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Response To Retinoic Acid Embryonic Heart Tube Anterior/posterior Pattern Specification Atrioventricular Canal Development Response To Drug Response To Estrogen Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Digestive Tract Morphogenesis Embryonic Foregut Morphogenesis Positive Regulation Of Cardioblast Differentiation Sertoli Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Transdifferentiation SMAD Protein Signal Transduction Atrial Septum Morphogenesis Lung Lobe Formation Intestinal Epithelial Cell Differentiation Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Glucose Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Epithelial Cell Fate Commitment Seminiferous Tubule Development Regulation Of Cardiac Muscle Cell Contraction	Negative Regulation Of Transcription From RNA Polymerase II Promoter Patterning Of Blood Vessels Transcription From RNA Polymerase II Promoter Inflammatory Response Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To UV Cellular Respiration Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Synaptic Plasticity Smooth Muscle Cell Differentiation Muscle Cell Development Cellular Response To Lithium Ion Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Peptide hormone metabolism Generic Transcription Pathway Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) YAP1- and WWTR1 (TAZ)-stimulated gene expression Factors involved in megakaryocyte development and platelet production Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS		Myopia (pathological) ( 23049088) Retinal vascular caliber ( 21060863)	Height ( 20881960 23563607)
Protein-Protein Interactions		23 interactors: ALX4 CRIP2 EP300 FOS HAND2 ID1 ID2 ID3 JARID2 MAPK1 MAPK3 MDC1 MED1 MEF2C NFATC4 NKX2-5 NR5A1 PIAS1 SP1 SRF TBX5 ZBTB3 ZFPM2	11 interactors: CCNG1 CREBBP GATA4 GPR22 JUP MAPK14 MAPK8 MAPK9 NR1I2 YWHAQ YWHAZ
Entrez ID		2626	4776
HPRD ID		08994	09096
Ensembl ID		ENSG00000136574	ENSG00000100968
Uniprot IDs		B3KUF4 B7ZKZ4 P43694	Q14934
PDB IDs		2M9W	2YRP
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Tissue Development RNA Metabolic Process Heart Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Gene Expression Organ Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Organ Development Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cardiovascular System Development Cardiac Chamber Development Tube Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cardiac Ventricle Development Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Embryonic Organ Development Muscle Structure Development Biosynthetic Process Regulation Of Gene Expression System Development Regulation Of Nitrogen Compound Metabolic Process Epithelium Development Embryo Development Striated Muscle Tissue Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Multicellular Organismal Development Positive Regulation Of Metabolic Process Muscle Tissue Development Anatomical Structure Morphogenesis Blood Vessel Development Anatomical Structure Development Heart Morphogenesis Vasculature Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Ventricle Morphogenesis	Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Transport Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Stimulus Regulation Of Intracellular Transport JUN Phosphorylation Positive Regulation Of Apoptotic Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Response To Mechanical Stimulus Response To Organic Substance Positive Regulation Of Mitochondrion Organization Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Signal Transduction Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Response To Abiotic Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Organic Substance Signaling Cell Communication Toll-like Receptor 4 Signaling Pathway Regulation Of Establishment Of Protein Localization Response To Stimulus Regulation Of Signaling Regulation Of Mitochondrion Organization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Protein Localization Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Response To Organonitrogen Compound Response To Lipid Positive Regulation Of Gene Expression Pattern Recognition Receptor Signaling Pathway Cellular Response To Lipid Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin
Tagcloud ?		6j arm assigned assignment backcross c57bl chromosome closely clu determination disorganization dnas ds ectopic f1 hybrid kb lineage mapped mapping mus places rodent somatic southern speculate spretus vicinity	100mg 1beta 200mg 3mg aps astragalus colitis dai dexamethasone dexm elisa ethanol experimental expressions forty hapten herb ip macroscopic medicinal membranaceus microscopic polysaccharides receiving saline scores tnbs tnf vehicle
Tagcloud (Difference) ?		6j arm assigned assignment backcross c57bl chromosome closely clu determination disorganization dnas ds ectopic f1 hybrid kb lineage mapped mapping mus places rodent somatic southern speculate spretus vicinity	100mg 1beta 200mg 3mg aps astragalus colitis dai dexamethasone dexm elisa ethanol experimental expressions forty hapten herb ip macroscopic medicinal membranaceus microscopic polysaccharides receiving saline scores tnbs tnf vehicle
Tagcloud (Intersection) ?