GATA4 and NFATC4

Number of citations of the paper that reports this interaction (PubMedID 9568714)
61

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		GATA4	NFATC4
Description		GATA binding protein 4	nuclear factor of activated T cells 4
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Transcription Regulator Complex Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Sequence-specific DNA Binding Metal Ion Binding NFAT Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Co-SMAD Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Atrioventricular Node Development Aortic Valve Morphogenesis Atrioventricular Valve Formation Endocardial Cushion Development Cardiac Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Septum Development Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Endoderm Development Heart Development Male Gonad Development Response To Xenobiotic Stimulus Response To Mechanical Stimulus Anatomical Structure Morphogenesis Tissue Development Negative Regulation Of Autophagy Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Differentiation Positive Regulation Of BMP Signaling Pathway Response To Vitamin A Embryonic Heart Tube Anterior/posterior Pattern Specification Atrioventricular Canal Development Wound Healing Cell Fate Commitment Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Foregut Morphogenesis Cardiac Muscle Cell Differentiation Transdifferentiation Atrial Septum Morphogenesis Intestinal Epithelial Cell Differentiation Cardiac Muscle Tissue Regeneration Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Glucose Stimulus Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Inflammatory Response Heart Development Long-term Memory Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Calcineurin-NFAT Signaling Cascade Cellular Response To UV Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Transcription By RNA Polymerase II Dendrite Morphogenesis Negative Regulation Of Dendrite Morphogenesis Neuron Apoptotic Process Synapse Maturation Long-term Synaptic Potentiation Cellular Response To Lithium Ion Vascular Associated Smooth Muscle Cell Development Negative Regulation Of MiRNA Transcription Negative Regulation Of Synapse Maturation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Physiological factors Transcriptional regulation of testis differentiation Cardiogenesis Formation of lateral plate mesoderm Formation of definitive endoderm Factors involved in megakaryocyte development and platelet production Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Diseases		Atrial septal defect
GWAS		A body shape index ( 34021172) Adventurousness ( 30643258) Atrial fibrillation ( 30061737 29892015) Brain morphology (MOSTest) ( 32665545) Brugada syndrome ( 35210625) Diastolic blood pressure ( 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Left ventricular global circumferential strain (MTAG) ( 33495596) Left ventricular global longitudinal strain (MTAG) ( 33495596) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Myopia (pathological) ( 23049088) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Refractive error ( 32231278) Retinal vascular caliber ( 21060863) Systolic blood pressure ( 28739976 28135244 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Testicular germ cell tumor ( 28604728) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Appendicular lean mass ( 33097823) Diastolic blood pressure ( 27841878) Height ( 20881960 23563607 25282103) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		26 interacting genes: ALX4 CRIP2 EP300 FOS HAND2 ID1 ID2 ID3 JARID2 MAPK1 MAPK3 MDC1 MED1 MEF2C NFATC4 NKX2-5 NR5A1 PIAS1 PRKN PRPF19 RACK1 SP1 SRF TBX5 ZBTB3 ZFPM2	12 interacting genes: CCNG1 CREBBP GATA4 GPR22 JUP MAPK14 MAPK8 MAPK9 NLGN3 NR1I2 YWHAQ YWHAZ
Entrez ID		2626	4776
HPRD ID		08994	09096
Ensembl ID		ENSG00000136574	ENSG00000100968
Uniprot IDs		B3KUF4 B6DU75 P43694	Q14934
PDB IDs		2M9W 8VG0 8VG1	2YRP
Enriched GO Terms of Interacting Partners?		Heart Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Animal Organ Development Regulation Of Developmental Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Embryonic Morphogenesis Anatomical Structure Morphogenesis Cellular Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Protein-DNA Complex Regulation Of Metabolic Process Cell Development Hematopoietic Or Lymphoid Organ Development Animal Organ Morphogenesis Cell Differentiation Regulation Of Multicellular Organismal Development Negative Regulation Of Developmental Process Nucleus Cardiac Ventricle Formation DNA Binding Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Nucleoplasm Positive Regulation Of Developmental Process Cardiac Chamber Formation Muscle Tissue Development Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Gland Development Learning Or Memory DNA-templated Transcription Transcription By RNA Polymerase II	MAP Kinase Activity Protein Phosphatase Binding JUN Kinase Activity Regulation Of Protein Localization To Nucleus NFAT Protein Binding Response To Mechanical Stimulus Intracellular Signaling Cassette Response To Nutrient Levels Cellular Senescence Energy Homeostasis MAPK Cascade Positive Regulation Of Protein Localization To Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Cyclase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Fc-epsilon Receptor Signaling Pathway Response To UV Negative Regulation Of RNA Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Immune Response Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Regulation Of Protein Localization Multicellular Organismal-level Homeostasis Regulation Of MRNA Stability Cellular Response To Molecule Of Bacterial Origin Canonical Inflammasome Complex Assembly Positive Regulation Of Protein Import Into Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of RNA Stability Signal Transduction Nuclear Receptor Binding Rhythmic Process Cellular Response To Nutrient Levels Positive Regulation Of Macromolecule Biosynthetic Process Gamma-catenin-TCF7L2 Complex Fc Receptor Signaling Pathway JUN Phosphorylation Regulation Of Biological Quality
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