GATA4 and RACK1

Number of citations of the paper that reports this interaction (PubMedID 27208796)
0

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)

		GATA4	RACK1
Description		GATA binding protein 4	receptor for activated C kinase 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body RNA Polymerase II Transcription Regulator Complex	Phagocytic Cup Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Ribosome Plasma Membrane Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Dendrite Midbody Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome IRE1-RACK1-PP2A Complex Ribonucleoprotein Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Sequence-specific DNA Binding Metal Ion Binding NFAT Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Co-SMAD Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Enzyme Activator Activity Ion Channel Inhibitor Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Phosphatase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Tyrosine Kinase Inhibitor Activity Cyclin Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Ribosome Binding Translation Regulator Activity Cadherin Binding BH3 Domain Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Atrioventricular Node Development Aortic Valve Morphogenesis Atrioventricular Valve Formation Endocardial Cushion Development Cardiac Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Septum Development Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Endoderm Development Heart Development Male Gonad Development Response To Xenobiotic Stimulus Response To Mechanical Stimulus Anatomical Structure Morphogenesis Tissue Development Negative Regulation Of Autophagy Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Differentiation Positive Regulation Of BMP Signaling Pathway Response To Vitamin A Embryonic Heart Tube Anterior/posterior Pattern Specification Atrioventricular Canal Development Wound Healing Cell Fate Commitment Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Foregut Morphogenesis Cardiac Muscle Cell Differentiation Transdifferentiation Atrial Septum Morphogenesis Intestinal Epithelial Cell Differentiation Cardiac Muscle Tissue Regeneration Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Glucose Stimulus Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of Protein Phosphorylation Cytoplasmic Translation Translation Regulation Of Translation Apoptotic Process Gastrulation Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Translation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Positive Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Apoptotic Process Pigmentation Positive Regulation Of GTPase Activity Negative Regulation Of Smoothened Signaling Pathway Rhythmic Process Negative Regulation Of Phagocytosis Regulation Of Cell Division Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Rescue Of Stalled Ribosome Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Regulation Of Establishment Of Cell Polarity Positive Regulation Of Gastrulation Negative Regulation Of Translational Frameshifting Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Physiological factors Transcriptional regulation of testis differentiation Cardiogenesis Formation of lateral plate mesoderm Formation of definitive endoderm Factors involved in megakaryocyte development and platelet production Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells	Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR1-mediated ceramide production Degradation of CDH1
Drugs			Copper
Diseases		Atrial septal defect
GWAS		A body shape index ( 34021172) Adventurousness ( 30643258) Atrial fibrillation ( 30061737 29892015) Brain morphology (MOSTest) ( 32665545) Brugada syndrome ( 35210625) Diastolic blood pressure ( 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Left ventricular global circumferential strain (MTAG) ( 33495596) Left ventricular global longitudinal strain (MTAG) ( 33495596) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Myopia (pathological) ( 23049088) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Refractive error ( 32231278) Retinal vascular caliber ( 21060863) Systolic blood pressure ( 28739976 28135244 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Testicular germ cell tumor ( 28604728) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		26 interacting genes: ALX4 CRIP2 EP300 FOS HAND2 ID1 ID2 ID3 JARID2 MAPK1 MAPK3 MDC1 MED1 MEF2C NFATC4 NKX2-5 NR5A1 PIAS1 PRKN PRPF19 RACK1 SP1 SRF TBX5 ZBTB3 ZFPM2	112 interacting genes: ACTN2 ADH1B ADRB2 AGTRAP AR ARRDC3 ATG14 ATG5 AURKB BCL2L11 BECN1 BIRC6 BRCA1 CCNA1 CDKN1A CHERP CLEC1B CNOT2 CRMP1 CSF2RB DDX19B DNM1 DYNLL1 EED EIF6 ELOB EP300 EPOR ESR1 ESS2 FYN GABRB3 GATA4 GGN GNB1 GOLM1 GPBP1 GRAP2 GRIN2B HABP4 HIF1A HNRNPH2 IFNAR1 IFNAR2 IGF1R IK IL2RB IL4R IL7R INSR ITGB1 ITGB2 ITGB5 ITGB7 JAK1 KLHL20 LRP12 MAPK6 MCPH1 MKRN2 MTNR1A NFATC1 NR3C1 NSMAF OLA1 PABPC1 PDE4D PIK3R4 PLCG1 PLEC PRKAA1 PRKAB2 PRKAR2A PRKCA PRKCB PRKCD PRKCE PRKD1 PRPF31 PTN PTOV1 PTPRM RASA1 RASA3 RB1 RHOA SAT1 SLC27A6 SLC6A3 SLC9A5 SRC SREK1 ST7 STAT1 STAT3 SUMO4 SYT1 TARDBP TBXA2R TENM1 TMEM131 TNFRSF1A TP63 TP73 TSC22D4 TUBB TUBG1 TYK2 USP40 USP54 WDR83 ZSCAN12
Entrez ID		2626	10399
HPRD ID		08994	01503
Ensembl ID		ENSG00000136574	ENSG00000204628
Uniprot IDs		B3KUF4 B6DU75 P43694	E9KL35 P63244
PDB IDs		2M9W 8VG0 8VG1	4AOW 4UG0 4V5Z 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7NWH 7QP6 7QP7 7R4X 7TQL 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Heart Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Animal Organ Development Regulation Of Developmental Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Embryonic Morphogenesis Anatomical Structure Morphogenesis Cellular Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Protein-DNA Complex Regulation Of Metabolic Process Cell Development Hematopoietic Or Lymphoid Organ Development Animal Organ Morphogenesis Cell Differentiation Regulation Of Multicellular Organismal Development Negative Regulation Of Developmental Process Nucleus Cardiac Ventricle Formation DNA Binding Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Nucleoplasm Positive Regulation Of Developmental Process Cardiac Chamber Formation Muscle Tissue Development Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Gland Development Learning Or Memory DNA-templated Transcription Transcription By RNA Polymerase II	Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Receptor Complex Regulation Of Intracellular Signal Transduction Protein Kinase Binding Plasma Membrane Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization Regulation Of Programmed Cell Death Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Developmental Process Regulation Of Apoptotic Process Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Angiogenesis Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Process Positive Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Vasculature Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Biological Quality Intracellular Signaling Cassette Cellular Response To Hormone Stimulus Negative Regulation Of Apoptotic Process Regulation Of Developmental Process Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Reactive Oxygen Species Metabolic Process Transcription Corepressor Binding Phosphorylation Developmental Process Enzyme Binding Positive Regulation Of Cellular Component Organization Identical Protein Binding Regulation Of Glycolytic Process Protein Phosphorylation Cytoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Transport Regulation Of Protein Localization Negative Regulation Of Intracellular Signal Transduction Response To Hormone
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