GATA4 and CRIP2

Number of citations of the paper that reports this interaction (PMID 12530967)
55

Data Source:
HPRD (in vitro, in vivo)

		GATA4	CRIP2
Gene Name		GATA binding protein 4	cysteine-rich protein 2
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex	Cell Cortex Extracellular Matrix
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Enhancer Sequence-specific DNA Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Activating Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding NFAT Protein Binding Co-SMAD Binding	Zinc Ion Binding
	Biological Process	In Utero Embryonic Development Gastrulation With Mouth Forming Second Endoderm Formation Heart Looping Atrioventricular Valve Formation Endocardial Cushion Development Cardiac Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cell-cell Signaling Spermatogenesis Endoderm Development Blood Coagulation Male Gonad Development Response To Mechanical Stimulus Negative Regulation Of Autophagy Positive Regulation Vascular Endothelial Growth Factor Production Cardiac Muscle Hypertrophy In Response To Stress Signal Transduction Involved In Regulation Of Gene Expression BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Response To Retinoic Acid Embryonic Heart Tube Anterior/posterior Pattern Specification Atrioventricular Canal Development Response To Drug Response To Estrogen Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Digestive Tract Morphogenesis Embryonic Foregut Morphogenesis Positive Regulation Of Cardioblast Differentiation Sertoli Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Transdifferentiation SMAD Protein Signal Transduction Atrial Septum Morphogenesis Lung Lobe Formation Intestinal Epithelial Cell Differentiation Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Glucose Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Epithelial Cell Fate Commitment Seminiferous Tubule Development Regulation Of Cardiac Muscle Cell Contraction	Positive Regulation Of Cell Proliferation Hemopoiesis
Pathways		Peptide hormone metabolism Generic Transcription Pathway Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) YAP1- and WWTR1 (TAZ)-stimulated gene expression Factors involved in megakaryocyte development and platelet production Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS		Myopia (pathological) ( 23049088) Retinal vascular caliber ( 21060863)
Protein-Protein Interactions		23 interactors: ALX4 CRIP2 EP300 FOS HAND2 ID1 ID2 ID3 JARID2 MAPK1 MAPK3 MDC1 MED1 MEF2C NFATC4 NKX2-5 NR5A1 PIAS1 SP1 SRF TBX5 ZBTB3 ZFPM2	17 interactors: APP ATN1 ATP1B1 ATXN1 GADD45G GATA4 GATA6 KLF10 NOTCH3 OSGEP PCYT2 PRKG1 PTPN13 SMN1 SPRY2 SRF TK1
Entrez ID		2626	1397
HPRD ID		08994	03113
Ensembl ID		ENSG00000136574	ENSG00000182809
Uniprot IDs		B3KUF4 B7ZKZ4 P43694	P52943
PDB IDs		2M9W	2CU8
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Tissue Development RNA Metabolic Process Heart Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Gene Expression Organ Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Organ Development Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cardiovascular System Development Cardiac Chamber Development Tube Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cardiac Ventricle Development Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Embryonic Organ Development Muscle Structure Development Biosynthetic Process Regulation Of Gene Expression System Development Regulation Of Nitrogen Compound Metabolic Process Epithelium Development Embryo Development Striated Muscle Tissue Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Multicellular Organismal Development Positive Regulation Of Metabolic Process Muscle Tissue Development Anatomical Structure Morphogenesis Blood Vessel Development Anatomical Structure Development Heart Morphogenesis Vasculature Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Ventricle Morphogenesis	Blood Coagulation Hemostasis Multicellular Organismal Development Regulation Of Body Fluid Levels System Development Wound Healing Regulation Of Muscle Contraction Positive Regulation Of Cardioblast Differentiation Developmental Process Response To Wounding Tube Development Organ Development Cardiac Vascular Smooth Muscle Cell Differentiation Anatomical Structure Development RNA Metabolic Process Lung Development Respiratory Tube Development Associative Learning Muscle System Process Developmental Growth Negative Regulation Of Cellular Metabolic Process Respiratory System Development Regulation Of Developmental Growth Cell Fate Commitment Nucleobase-containing Compound Metabolic Process Cardiac Muscle Hypertrophy In Response To Stress Coronary Vasculature Development Cardiac Muscle Cell Differentiation Response To Abiotic Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Vascular Smooth Muscle Cell Differentiation Formation Of Primary Germ Layer Intestinal Epithelial Cell Differentiation Cardiocyte Differentiation Relaxation Of Muscle Cellular Response To Gonadotropin Stimulus Digestive Tract Development Cardiac Muscle Hypertrophy Cellular Nitrogen Compound Metabolic Process Learning Cardiac Chamber Development Muscle Hypertrophy Regulation Of Transcription From RNA Polymerase II Promoter Digestive System Development Positive Regulation Of Developmental Growth Positive Regulation Of Cardiac Muscle Cell Proliferation Cell Differentiation Gene Expression Forebrain Development
Tagcloud ?		6j arm assigned assignment backcross c57bl chromosome closely clu determination disorganization dnas ds ectopic f1 hybrid kb lineage mapped mapping mus places rodent somatic southern speculate spretus vicinity
Tagcloud (Difference) ?		6j arm assigned assignment backcross c57bl chromosome closely clu determination disorganization dnas ds ectopic f1 hybrid kb lineage mapped mapping mus places rodent somatic southern speculate spretus vicinity
Tagcloud (Intersection) ?