GATA4 and SRF

Number of citations of the paper that reports this interaction (PMID 11003651)
38

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		GATA4	SRF
Gene Name		GATA binding protein 4	serum response factor (c-fos serum response element-binding transcription factor)
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex	Nuclear Chromatin Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Enhancer Sequence-specific DNA Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Activating Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding NFAT Protein Binding Co-SMAD Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Serum Response Element Binding Chromatin DNA Binding Protein Homodimerization Activity
	Biological Process	In Utero Embryonic Development Gastrulation With Mouth Forming Second Endoderm Formation Heart Looping Atrioventricular Valve Formation Endocardial Cushion Development Cardiac Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cell-cell Signaling Spermatogenesis Endoderm Development Blood Coagulation Male Gonad Development Response To Mechanical Stimulus Negative Regulation Of Autophagy Positive Regulation Vascular Endothelial Growth Factor Production Cardiac Muscle Hypertrophy In Response To Stress Signal Transduction Involved In Regulation Of Gene Expression BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Response To Retinoic Acid Embryonic Heart Tube Anterior/posterior Pattern Specification Atrioventricular Canal Development Response To Drug Response To Estrogen Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Digestive Tract Morphogenesis Embryonic Foregut Morphogenesis Positive Regulation Of Cardioblast Differentiation Sertoli Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Transdifferentiation SMAD Protein Signal Transduction Atrial Septum Morphogenesis Lung Lobe Formation Intestinal Epithelial Cell Differentiation Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Glucose Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Epithelial Cell Fate Commitment Seminiferous Tubule Development Regulation Of Cardiac Muscle Cell Contraction	Patterning Of Blood Vessels Response To Hypoxia Mesoderm Formation Neuron Migration Trophectodermal Cell Differentiation Heart Looping Morphogenesis Of An Epithelial Sheet Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Transcription From RNA Polymerase II Promoter Cell-matrix Adhesion Heart Development Long-term Memory Negative Regulation Of Cell Proliferation Associative Learning Response To Toxic Substance Response To Hormone Epithelial Structure Maintenance Positive Regulation Of Transcription Via Serum Response Element Binding Hippocampus Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Contractile Actin Filament Bundle Assembly Regulation Of Cell Adhesion Platelet Activation Platelet Formation Negative Regulation Of Cell Migration Neuron Projection Development Regulation Of Water Loss Via Skin Response To Cytokine Megakaryocyte Development Dorsal Aorta Morphogenesis MRNA Transcription From RNA Polymerase II Promoter Stress Fiber Assembly Skin Morphogenesis Positive Thymic T Cell Selection Sarcomere Organization Positive Regulation Of Cell Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Transcription By Glucose Muscle Cell Cellular Homeostasis Developmental Growth Neuron Development Erythrocyte Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Filopodium Assembly Cardiac Myofibril Assembly Angiogenesis Involved In Wound Healing Hematopoietic Stem Cell Differentiation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Long Term Synaptic Depression Heart Trabecula Formation Cardiac Vascular Smooth Muscle Cell Differentiation Eyelid Development In Camera-type Eye Tight Junction Assembly Cellular Response To Glucose Stimulus Primitive Streak Formation Epithelial Cell-cell Adhesion Cellular Senescence Negative Regulation Of Beta-amyloid Clearance
Pathways		Peptide hormone metabolism Generic Transcription Pathway Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) YAP1- and WWTR1 (TAZ)-stimulated gene expression Factors involved in megakaryocyte development and platelet production Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS		Myopia (pathological) ( 23049088) Retinal vascular caliber ( 21060863)
Protein-Protein Interactions		23 interactors: ALX4 CRIP2 EP300 FOS HAND2 ID1 ID2 ID3 JARID2 MAPK1 MAPK3 MDC1 MED1 MEF2C NFATC4 NKX2-5 NR5A1 PIAS1 SP1 SRF TBX5 ZBTB3 ZFPM2	72 interactors: ALDH3A1 ASCC1 ASCC2 ASCC3 ATF6 BARX2 CAMK2A CASP3 CASP6 CASP7 CASP8 CASP9 CD63 CEBPB CIRBP CNTN2 CREB1 CREBBP CRIP2 CSNK2A1 ELK1 ELK4 ETV4 FHL1 FHL2 FHL3 FHL5 FLI1 GATA4 GTF2F1 GTF2I HDAC4 HMGA1 HOPX KAT5 KDM6A MAPKAPK2 MINPP1 MKL1 MKL2 MYOCD MYOD1 MYOG NCOA1 NCOA6 NCOR2 NFKB1 NFYA NKX2-3 NKX2-5 NKX3-1 OGT PML PRKDC PRRX1 PYCARD RARG REL RELA RPS6KA1 RXRA RXRG SHBG SP1 SRC SRFBP1 SSRP1 TCF3 TEAD1 TRIM63 UBE2I ZIC3
Entrez ID		2626	6722
HPRD ID		08994	02788
Ensembl ID		ENSG00000136574	ENSG00000112658
Uniprot IDs		B3KUF4 B7ZKZ4 P43694	F5H6V4 P11831
PDB IDs		2M9W	1HBX 1K6O 1SRS
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Tissue Development RNA Metabolic Process Heart Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Gene Expression Organ Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Organ Development Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cardiovascular System Development Cardiac Chamber Development Tube Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cardiac Ventricle Development Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Embryonic Organ Development Muscle Structure Development Biosynthetic Process Regulation Of Gene Expression System Development Regulation Of Nitrogen Compound Metabolic Process Epithelium Development Embryo Development Striated Muscle Tissue Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Multicellular Organismal Development Positive Regulation Of Metabolic Process Muscle Tissue Development Anatomical Structure Morphogenesis Blood Vessel Development Anatomical Structure Development Heart Morphogenesis Vasculature Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Ventricle Morphogenesis	Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Organ Development Cell Differentiation Developmental Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Tissue Development Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Response To Lipid Anatomical Structure Development Regulation Of Cellular Process Anatomical Structure Morphogenesis System Development Response To Hormone Cellular Response To Organic Substance Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Heart Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Multicellular Organismal Development Negative Regulation Of Gene Expression Response To Steroid Hormone Intracellular Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process
Tagcloud ?		6j arm assigned assignment backcross c57bl chromosome closely clu determination disorganization dnas ds ectopic f1 hybrid kb lineage mapped mapping mus places rodent somatic southern speculate spretus vicinity	ali bellan biol chem classes coactivator coexpression concluded cooperate creb element finding glutathione harel homologue hybrid mammalian potentiated pull ramirez robin src sre steroid synergistically transactivations transferase trouche yeast
Tagcloud (Difference) ?		6j arm assigned assignment backcross c57bl chromosome closely clu determination disorganization dnas ds ectopic f1 kb lineage mapped mapping mus places rodent somatic southern speculate spretus vicinity	ali bellan biol chem classes coactivator coexpression concluded cooperate creb element finding glutathione harel homologue mammalian potentiated pull ramirez robin src sre steroid synergistically transactivations transferase trouche yeast
Tagcloud (Intersection) ?		hybrid