GATA4 and JARID2

Number of citations of the paper that reports this interaction (PubMedID 15542826)
50

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		GATA4	JARID2
Description		GATA binding protein 4	jumonji and AT-rich interaction domain containing 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Mitochondrion Histone Methyltransferase Complex ESC/E(Z) Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Sequence-specific DNA Binding Metal Ion Binding NFAT Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Co-SMAD Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Chromatin Binding Protein Binding Histone Demethylase Activity Ubiquitin Binding Histone H3K27 Methyltransferase Activity Ubiquitin-modified Histone Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Atrioventricular Node Development Aortic Valve Morphogenesis Atrioventricular Valve Formation Endocardial Cushion Development Cardiac Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Septum Development Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Endoderm Development Heart Development Male Gonad Development Response To Xenobiotic Stimulus Response To Mechanical Stimulus Anatomical Structure Morphogenesis Tissue Development Negative Regulation Of Autophagy Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Differentiation Positive Regulation Of BMP Signaling Pathway Response To Vitamin A Embryonic Heart Tube Anterior/posterior Pattern Specification Atrioventricular Canal Development Wound Healing Cell Fate Commitment Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Foregut Morphogenesis Cardiac Muscle Cell Differentiation Transdifferentiation Atrial Septum Morphogenesis Intestinal Epithelial Cell Differentiation Cardiac Muscle Tissue Regeneration Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Glucose Stimulus Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Liver Development Chromatin Organization Chromatin Remodeling Central Nervous System Development Cell Population Proliferation Regulation Of Gene Expression Cell Differentiation Regulation Of Cell Population Proliferation Negative Regulation Of DNA-templated Transcription Spleen Development Thymus Development System Development Stem Cell Differentiation Cardiac Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Proliferation Random Inactivation Of X Chromosome Facultative Heterochromatin Formation Protein Localization To Pericentric Heterochromatin Cellular Response To Leukemia Inhibitory Factor
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Physiological factors Transcriptional regulation of testis differentiation Cardiogenesis Formation of lateral plate mesoderm Formation of definitive endoderm Factors involved in megakaryocyte development and platelet production Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells	PRC2 methylates histones and DNA
Drugs
Diseases		Atrial septal defect
GWAS		A body shape index ( 34021172) Adventurousness ( 30643258) Atrial fibrillation ( 30061737 29892015) Brain morphology (MOSTest) ( 32665545) Brugada syndrome ( 35210625) Diastolic blood pressure ( 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Left ventricular global circumferential strain (MTAG) ( 33495596) Left ventricular global longitudinal strain (MTAG) ( 33495596) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Myopia (pathological) ( 23049088) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Refractive error ( 32231278) Retinal vascular caliber ( 21060863) Systolic blood pressure ( 28739976 28135244 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Testicular germ cell tumor ( 28604728) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Appendicular lean mass ( 33097823) Birth weight ( 31043758) Chronotype ( 30696823) Hand grip strength ( 29691431) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494) Lymphoma ( 23349640) Multiple myeloma ( 27363682) Multiple sclerosis (severity) ( 19010793) Nevus count or cutaneous melanoma ( 32341527) Ovarian reserve ( 22116950)
Interacting Genes		26 interacting genes: ALX4 CRIP2 EP300 FOS HAND2 ID1 ID2 ID3 JARID2 MAPK1 MAPK3 MDC1 MED1 MEF2C NFATC4 NKX2-5 NR5A1 PIAS1 PRKN PRPF19 RACK1 SP1 SRF TBX5 ZBTB3 ZFPM2	3 interacting genes: GATA4 NKX2-5 SETDB1
Entrez ID		2626	3720
HPRD ID		08994	03355
Ensembl ID		ENSG00000136574	ENSG00000008083
Uniprot IDs		B3KUF4 B6DU75 P43694	Q92833
PDB IDs		2M9W 8VG0 8VG1	4X3E 5HYN 5LS6 5WAI 6C23 6C24 6NQ3 6WKR 7KSO 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH
Enriched GO Terms of Interacting Partners?		Heart Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Animal Organ Development Regulation Of Developmental Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Embryonic Morphogenesis Anatomical Structure Morphogenesis Cellular Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Protein-DNA Complex Regulation Of Metabolic Process Cell Development Hematopoietic Or Lymphoid Organ Development Animal Organ Morphogenesis Cell Differentiation Regulation Of Multicellular Organismal Development Negative Regulation Of Developmental Process Nucleus Cardiac Ventricle Formation DNA Binding Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Nucleoplasm Positive Regulation Of Developmental Process Cardiac Chamber Formation Muscle Tissue Development Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Gland Development Learning Or Memory DNA-templated Transcription Transcription By RNA Polymerase II	Atrioventricular Node Development Atrial Septum Morphogenesis Aortic Valve Morphogenesis Cardiac Muscle Cell Differentiation Negative Regulation Of Striated Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cardiac Ventricle Morphogenesis DNA-binding Transcription Activator Activity Cardiac Septum Development Cardiocyte Differentiation Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Muscle Cell Apoptotic Process Heart Valve Morphogenesis Mesenchyme Development Cardiac Muscle Tissue Development Heart Looping Embryonic Heart Tube Morphogenesis Striated Muscle Cell Differentiation Cardiac Septum Morphogenesis Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Muscle Cell Differentiation Epithelial Tube Morphogenesis Striated Muscle Tissue Development Septum Secundum Development Nkx-2.5 Complex Purkinje Myocyte Differentiation RNA Polymerase II Transcription Regulator Complex Muscle Tissue Development Regulation Of Muscle Contraction Atrial Cardiac Muscle Cell Development Atrioventricular Node Cell Fate Commitment Cell Fate Commitment Atrial Septum Secundum Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Heart Contraction His-Purkinje System Cell Differentiation Pulmonary Myocardium Development Proepicardium Development Ventricular Cardiac Myofibril Assembly Right Ventricular Cardiac Muscle Tissue Morphogenesis Embryonic Heart Tube Anterior/posterior Pattern Specification Regulation Of Blood Circulation Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Transcription Cis-regulatory Region Binding Regulation Of Muscle System Process Cardiac Muscle Tissue Regeneration Histone H3K9 Trimethyltransferase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?