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ZNRF4 and UBE2D4
Number of citations of the paper that reports this interaction (PMID
19690564
)
33
Data Source:
BioGRID
(two hybrid)
ZNRF4
UBE2D4
Gene Name
zinc and ring finger 4
ubiquitin-conjugating enzyme E2D 4 (putative)
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Integral Component Of Membrane
Molecular Function
Zinc Ion Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Protein Ubiquitination
Protein K29-linked Ubiquitination
Protein K27-linked Ubiquitination
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein K6-linked Ubiquitination
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
9 interactors:
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E3
UBE2G2
UBE2N
UBE2W
90 interactors:
AMFR
ARIH2
BFAR
BIRC8
CADPS2
CHFR
CNOT4
DAZAP2
DTX1
DTX2
DTX3
DTX3L
DZIP3
INCA1
LRSAM1
MAGEA11
MAP3K1
MARCH3
MGRN1
MIB1
MID1
MID2
MKRN2
MKRN3
MUL1
MYBL2
MYLIP
OTUB1
PHF7
PJA2
RBCK1
RCHY1
RFWD3
RING1
RLIM
RMND5B
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF125
RNF126
RNF13
RNF130
RNF138
RNF14
RNF150
RNF165
RNF166
RNF167
RNF181
RNF185
RNF2
RNF25
RNF26
RNF38
RNF4
RNF43
RNF5
RNF7
SIAH1
TOPORS
TRAF6
TRAF7
TRIM10
TRIM17
TRIM2
TRIM25
TRIM27
TRIM3
TRIM31
TRIM35
TRIM38
TRIM39
TRIM43
TRIM45
TRIM5
TRIM50
TRIM8
UBE4A
UBOX5
UBTD1
UFM1
UHRF2
XIAP
ZNRF1
ZNRF2
ZNRF4
Entrez ID
148066
51619
HPRD ID
15895
14242
Ensembl ID
ENSG00000105428
ENSG00000078967
Uniprot IDs
Q8WWF5
Q9Y2X8
PDB IDs
Enriched GO Terms of Interacting Partners
?
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Ubiquitin-dependent Protein Catabolic Process
Protein K11-linked Ubiquitination
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Modification Process
Proteasomal Protein Catabolic Process
Toll-like Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Proteolysis
Activation Of Innate Immune Response
Protein K63-linked Ubiquitination
Cellular Protein Metabolic Process
Protein Monoubiquitination
Positive Regulation Of Innate Immune Response
Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Regulation Of Innate Immune Response
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Protein Metabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Regulation Of Ubiquitin-protein Transferase Activity
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Cellular Response To Oxygen Levels
Positive Regulation Of Protein Ubiquitination
Immune Response-regulating Signaling Pathway
Regulation Of Protein Ubiquitination
Regulation Of Chromosome Organization
Positive Regulation Of Immune Response
Mitotic Spindle Assembly Checkpoint
Histone Ubiquitination
Spindle Assembly Checkpoint
Mitotic Spindle Checkpoint
Negative Regulation Of Chromosome Segregation
Cellular Response To Stress
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein Polyubiquitination
Protein Autoubiquitination
Cellular Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Protein K63-linked Ubiquitination
Regulation Of Viral Entry Into Host Cell
Protein K48-linked Ubiquitination
Regulation Of Viral Release From Host Cell
Negative Regulation Of Viral Release From Host Cell
Negative Regulation Of Viral Entry Into Host Cell
Metabolic Process
Negative Regulation Of Viral Process
Catabolic Process
Proteolysis
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Viral Process
Protein Monoubiquitination
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Signal Transduction
Negative Regulation Of Viral Transcription
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cellular Process
Regulation Of Signal Transduction
Innate Immune Response
Interferon-gamma-mediated Signaling Pathway
Regulation Of Protein Ubiquitination
Cellular Response To Interferon-gamma
Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Apoptotic Process
Response To Interferon-gamma
Programmed Cell Death
Cell Death
Death
Histone Monoubiquitination
Tagcloud
?
accumulation
apoptosis
apoptotic
arsenic
cadmium
conjugating
degradation
downregulation
elevated
enzymes
family
hand
induce
inorganic
mercury
p53
promote
proteasomal
proximal
rat
suppressed
suppression
tubular
ubiquitin
ubiquitination
Tagcloud (Difference)
?
accumulation
apoptosis
apoptotic
arsenic
cadmium
conjugating
degradation
downregulation
elevated
enzymes
family
hand
induce
inorganic
mercury
p53
promote
proteasomal
proximal
rat
suppressed
suppression
tubular
ubiquitin
ubiquitination
Tagcloud (Intersection)
?