CSRP1 and ACTN1

Number of citations of the paper that reports this interaction (PMID 10926853)
6

Data Source:
HPRD (in vitro)

		CSRP1	ACTN1
Gene Name		cysteine and glycine-rich protein 1	actinin, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Focal Adhesion Extracellular Vesicular Exosome	Stress Fiber Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Fascia Adherens Focal Adhesion Z Disc Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	Zinc Ion Binding Poly(A) RNA Binding	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Ion Channel Binding Actin Filament Binding
	Biological Process	Platelet Aggregation	Platelet Degranulation Blood Coagulation Platelet Activation Extracellular Matrix Organization Cell Junction Assembly Regulation Of Apoptotic Process Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Crosslink Formation Regulation Of Nucleic Acid-templated Transcription
Pathways			Cell junction organization Syndecan interactions Response to elevated platelet cytosolic Ca2+ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Nephrin interactions Platelet degranulation Non-integrin membrane-ECM interactions Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs
Diseases
GWAS			Prostate cancer ( 23535732) Smoking behavior ( 19247474)
Protein-Protein Interactions		3 interactors: ACTN1 APP EGFR	70 interactors: ACTN3 ADORA2A APC ATXN2 ATXN7 CACNA1A CAMK2A CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 EPM2AIP1 ERBB2IP FBP1 FXN GFI1B GIPC1 GIT2 GRIA4 GRIN2A GTF2H1 ITGB1 KAT2B KCTD6 KPNA2 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SLC2A4 SORBS2 SPERT SRC SSX2IP TES TTN VCL XRCC4 ZYX
Entrez ID		1465	87
HPRD ID		00470	00020
Ensembl ID		ENSG00000159176	ENSG00000072110
Uniprot IDs		A8K268 B3KVC9 B4DY28 B4E2T4 P21291 Q5U0J2	P12814
PDB IDs			2EYI 2EYN
Enriched GO Terms of Interacting Partners?		Cell Activation Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Alkanesulfonate Metabolic Process Cell Adhesion Platelet Activation Regulation Of Peptidyl-tyrosine Phosphorylation Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Synaptic Growth At Neuromuscular Junction Astrocyte Activation Collateral Sprouting In Absence Of Injury Learning Or Memory Positive Regulation Of Cell Cycle Cognition Protein Localization To Tight Junction Activation Of Phospholipase A2 Activity Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Phospholipase A2 Activity Response To Light Stimulus Exocytosis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Response To Cobalamin Response To UV-A Extracellular Matrix Organization Extracellular Structure Organization Axon Choice Point Recognition Response To Hydroxyisoflavone Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Response To Oxidative Stress Blood Coagulation Hemostasis Protein Localization To Cell Junction Forebrain Development Response To Radiation Single-organism Behavior Cellular Localization Neuron Remodeling Metal Ion Homeostasis Positive Regulation Of Catenin Import Into Nucleus Regulation Of Cellular Ketone Metabolic Process Secretion By Cell Regulation Of Phospholipase A2 Activity Axonogenesis Regulation Of Superoxide Anion Generation	Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Organelle Organization Cell Development Regulation Of Protein Kinase Activity Actin Filament-based Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Cell-substrate Adhesion Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorus Metabolic Process Cell Differentiation Generation Of Neurons Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Stress Actomyosin Structure Organization Neuron Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Central Nervous System Development Positive Regulation Of Transferase Activity Regulation Of Signaling Response To Stimulus Response To Wounding Regulation Of Phosphorylation Cell-cell Junction Organization Regulation Of Cell Projection Organization Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Single Organismal Cell-cell Adhesion Adherens Junction Organization Neuron Projection Development Neuron Differentiation Anatomical Structure Development Blood Coagulation Cell Surface Receptor Signaling Pathway Cell Projection Organization Hemostasis Cell-matrix Adhesion Apical Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Neuron Projection Development
Tagcloud ?		activin alp c1orf19 cdm chsy cobblestone cryab dusp6 epas1 foetal gfpt2 grem1 hmgcs1 immunocytochemistry intermediary morphogenetic mt1x osr2 postn ppl rabgap1 sc4mol sox sox15 sqle srgn stro therein wif1	b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc
Tagcloud (Difference) ?		activin alp c1orf19 cdm chsy cobblestone cryab dusp6 epas1 foetal gfpt2 grem1 hmgcs1 immunocytochemistry intermediary morphogenetic mt1x osr2 postn ppl rabgap1 sc4mol sox sox15 sqle srgn stro therein wif1	b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc
Tagcloud (Intersection) ?