PTN and PSMD11

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		PTN	PSMD11
Description		pleiotrophin	proteasome 26S subunit, non-ATPase 11
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Protein-containing Complex Schaffer Collateral - CA1 Synapse	Proteasome Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle Proteasome Regulatory Particle, Lid Subcomplex Membrane Proteasome Accessory Complex Protein-containing Complex Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Phosphatase Inhibitor Activity Integrin Binding Protein Binding Growth Factor Activity Heparin Binding Protein Kinase Binding Carbohydrate Binding Chondroitin Sulfate Binding Molecular Function Activator Activity	Structural Molecule Activity Protein Binding
	Biological Process	Ossification Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Integrin-mediated Signaling Pathway Nervous System Development Negative Regulation Of Neuroblast Proliferation Learning Memory Positive Regulation Of Cell Population Proliferation Regulation Of Endothelial Cell Migration Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Bone Mineralization Positive Regulation Of Bone Mineralization Dendrite Regeneration Regulation Of Myelination Tissue Regeneration Receptor Clustering Ossification Involved In Bone Remodeling Estrous Cycle Positive Regulation Of Cell Differentiation Positive Regulation Of Ossification Decidualization Regulation Of Synaptic Plasticity Oogenesis Positive Regulation Of Axon Regeneration Positive Regulation Of Oligodendrocyte Differentiation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cell Division Dendrite Arborization Positive Regulation Of Dendrite Development Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Hemopoiesis Regulation Of Stem Cell Population Maintenance Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Stem Cell Differentiation	Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasome Assembly Stem Cell Differentiation
Pathways		Signaling by ALK Signaling by ALK MDK and PTN in ALK signaling MDK and PTN in ALK signaling	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Aluminium levels ( 26025379) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood protein levels ( 30072576) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Schizophrenia ( 25056061 29483656)	Schizophrenia ( 33169155)
Interacting Genes		101 interacting genes: ACTB ALK APOBEC3G ARIH2 ARL15 ASPH ATP5F1C ATRX BAG6 BARD1 BCCIP BCL2L1 BLOC1S1 BMI1 BTBD2 C11orf58 C7orf25 CAAP1 CACNB4 CAPZB CDH10 CDK5RAP2 CGA CHD3 COX6C CRCT1 CRELD1 CSTA CYP2E1 DNAJB11 DUSP12 EIF3F EVA1A FEZ1 FTL GADD45A GADD45G GIPC2 GLYAT GPD1 GPRASP2 GSDME GSK3B GSTP1 GTF2F1 HGH1 HSPBAP1 ITSN2 KPNB1 LAMA4 LUC7L2 MAD2L1BP MFRP MKKS MLLT3 MRPL44 MYCBP NAP1L5 NCAN NEK6 NUDT21 P4HB PFDN1 PIAS4 PLXNB2 PMF1 PPP2CA PSMB10 PSMD11 PSMD2 PTPRS PTPRZ1 RACK1 RBM23 RIT1 RNF167 ROR1 RPLP1 SAT1 SDC1 SDC3 SGSM2 SGTA SLC25A36 SNCAIP SPIN1 SSR1 STC2 SUPT7L TAC3 TAF1D TBRG4 TOMM20 TP53BP2 TSC22D1 TXNDC9 UBQLN1 UBQLN4 UTP3 WASHC3 WFDC2	38 interacting genes: APP BRD7 CCDC90B CCSER2 CDC42 CEBPA COPS2 COPS6 CRMP1 EEF1A1 EEF1G GAPDH GDF9 HAP1 IGSF21 LRIF1 MED31 NFKB2 PRKAA1 PRKAB2 PRKACA PRMT6 PTN PTPRK RBM48 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 TLE1 TP53 TUBB2A UNC119 USP4 ZBTB16 ZHX1
Entrez ID		5764	5717
HPRD ID		01199	05119
Ensembl ID		ENSG00000105894	ENSG00000108671
Uniprot IDs		A0A8V8TNI1 P21246	O00231
PDB IDs		2N6F 8VOH 8VOI	5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Stress	SMAD Protein Complex Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding SMAD Protein Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Embryonic Pattern Specification Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Metabolic Process Cardiac Conduction System Development Cell Surface Receptor Signaling Pathway Transcription Regulator Complex Protein-containing Complex Intracellular Signaling Cassette Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process DEAD/H-box RNA Helicase Binding Regulation Of MiRNA Transcription Chromatin Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Regulation Of MiRNA Metabolic Process Nucleotide-activated Protein Kinase Complex Positive Regulation Of Cell Differentiation Ureteric Bud Development Co-SMAD Binding Negative Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Primary MiRNA Processing Signal Transduction Mesonephric Tubule Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Mesonephric Epithelium Development Gastrulation Homomeric SMAD Protein Complex Nucleus Response To Growth Factor Protein Kinase Binding Positive Regulation Of MiRNA Transcription Positive Regulation Of Gene Expression Response To Glucose
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