PTN and CDH10

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PTN	CDH10
Gene Name		pleiotrophin	cadherin 10, type 2 (T2-cadherin)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Phosphatase Inhibitor Activity Growth Factor Activity Heparin Binding	Calcium Ion Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Nervous System Development Learning Positive Regulation Of Cell Proliferation Bone Mineralization Negative Regulation Of Catalytic Activity Positive Regulation Of Cell Division	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Single Organismal Cell-cell Adhesion Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization
Pathways			Cell junction organization Cell-cell junction organization Adherens junctions interactions
Drugs
Diseases
GWAS			β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Autism ( 19404256)
Protein-Protein Interactions		97 interactors: ACTB ALK APOBEC3G ARIH2 ARL15 ATP5C1 ATRX BAG6 BARD1 BCCIP BCL2L1 BLOC1S1 BMI1 BTBD2 C11orf58 C7orf25 CAAP1 CACNB4 CAPZB CCDC53 CDH10 CDK5RAP2 CGA CHD3 COX6C CRCT1 CRELD1 CSTA CYP2E1 DFNA5 DNAJB11 DUSP12 EIF3F EVA1A FEZ1 FTL GADD45A GADD45G GIPC2 GLYAT GNB2L1 GPD1 GPRASP2 GSK3B GSTP1 GTF2F1 HGH1 HSPBAP1 ITSN2 KPNB1 LAMA4 LUC7L2 MAD2L1BP MKKS MLLT3 MRPL44 MYCBP NAP1L5 NCAN NEK6 NUDT21 P4HB PFDN1 PIAS4 PLXNB2 PMF1 PPP2CA PSMB10 PSMD11 PSMD2 PTPRS PTPRZ1 RBM23 RIT1 RPLP1 SAT1 SDC1 SDC3 SGSM2 SGTA SLC25A36 SNCAIP SPIN1 SSR1 STC2 SUPT7L TAC3 TAF1D TBRG4 TOMM20 TP53BP2 TSC22D1 TXNDC9 UBQLN1 UBQLN4 UTP3 WFDC2	5 interactors: CDH6 CDH9 COPS6 JUP PTN
Entrez ID		5764	1008
HPRD ID		01199	05187
Ensembl ID		ENSG00000105894	ENSG00000040731
Uniprot IDs		P21246	Q9Y6N8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Cycle Nitrogen Compound Metabolic Process Apoptotic Process Central Nervous System Development Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Cell Death Regulation Of Cell Cycle Death Regulation Of Protein Catabolic Process Negative Regulation Of Transferase Activity Response To Endoplasmic Reticulum Stress Regulation Of Cell Death Regulation Of Cellular Process Signal Transduction By P53 Class Mediator Cell Cycle Process Negative Regulation Of Cell Cycle Positive Regulation Of Transferase Activity Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Brain Development Nervous System Development Regulation Of Intrinsic Apoptotic Signaling Pathway Signal Transduction In Response To DNA Damage Positive Regulation Of Protein Modification Process Viral Process Developmental Process Head Development Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Process Heterocycle Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Metabolic Process Anatomical Structure Development Regulation Of Signaling Cellular Response To Stress Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity	Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Endothelial Cell-cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Desmosome Assembly Cellular Response To Indole-3-methanol Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Adhesion Bundle Of His Cell To Purkinje Myocyte Communication Desmosome Organization Cullin Deneddylation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cytoskeletal Anchoring At Plasma Membrane Protein Deneddylation Regulation Of Cell Fate Specification Ventricular Cardiac Muscle Cell Action Potential Cellular Component Assembly Single Organismal Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cell Fate Commitment Epithelial Cell-cell Adhesion Cardiac Muscle Cell Action Potential Adherens Junction Assembly Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Detection Of Mechanical Stimulus Bone Mineralization
Tagcloud ?		04fmolt4 04mg 09mg 28ng 32ng 37g 58vo2ml 64g 71ng 94ng 99mg backgrounds bat carioca chf corticosterone ctrl d2 depot endocrine epididymal freezing glycemia impair kg0 retroperitoneal t4 triglycerides weights	apc atlas capture characterisation col6a3 crc devised dock2 exome fat4 genomes kras mutated nevertheless next predicts prognostication recurrently sequencing signature silent smad4 somatic staging stratifying tmem132d tnm vcan verified
Tagcloud (Difference) ?		04fmolt4 04mg 09mg 28ng 32ng 37g 58vo2ml 64g 71ng 94ng 99mg backgrounds bat carioca chf corticosterone ctrl d2 depot endocrine epididymal freezing glycemia impair kg0 retroperitoneal t4 triglycerides weights	apc atlas capture characterisation col6a3 crc devised dock2 exome fat4 genomes kras mutated nevertheless next predicts prognostication recurrently sequencing signature silent smad4 somatic staging stratifying tmem132d tnm vcan verified
Tagcloud (Intersection) ?