PTN and RACK1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PTN	RACK1
Description		pleiotrophin	receptor for activated C kinase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Protein-containing Complex Schaffer Collateral - CA1 Synapse	Phagocytic Cup Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Ribosome Plasma Membrane Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Dendrite Midbody Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome IRE1-RACK1-PP2A Complex Ribonucleoprotein Complex
	Molecular Function	Protein Phosphatase Inhibitor Activity Integrin Binding Protein Binding Growth Factor Activity Heparin Binding Protein Kinase Binding Carbohydrate Binding Chondroitin Sulfate Binding Molecular Function Activator Activity	RNA Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Enzyme Activator Activity Ion Channel Inhibitor Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Phosphatase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Tyrosine Kinase Inhibitor Activity Cyclin Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Ribosome Binding Translation Regulator Activity Cadherin Binding BH3 Domain Binding Molecular Adaptor Activity
	Biological Process	Ossification Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Integrin-mediated Signaling Pathway Nervous System Development Negative Regulation Of Neuroblast Proliferation Learning Memory Positive Regulation Of Cell Population Proliferation Regulation Of Endothelial Cell Migration Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Bone Mineralization Positive Regulation Of Bone Mineralization Dendrite Regeneration Regulation Of Myelination Tissue Regeneration Receptor Clustering Ossification Involved In Bone Remodeling Estrous Cycle Positive Regulation Of Cell Differentiation Positive Regulation Of Ossification Decidualization Regulation Of Synaptic Plasticity Oogenesis Positive Regulation Of Axon Regeneration Positive Regulation Of Oligodendrocyte Differentiation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cell Division Dendrite Arborization Positive Regulation Of Dendrite Development Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Hemopoiesis Regulation Of Stem Cell Population Maintenance Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Stem Cell Differentiation	Positive Regulation Of Protein Phosphorylation Cytoplasmic Translation Translation Regulation Of Translation Apoptotic Process Gastrulation Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Translation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Positive Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Apoptotic Process Pigmentation Positive Regulation Of GTPase Activity Negative Regulation Of Smoothened Signaling Pathway Rhythmic Process Negative Regulation Of Phagocytosis Regulation Of Cell Division Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Rescue Of Stalled Ribosome Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Regulation Of Establishment Of Cell Polarity Positive Regulation Of Gastrulation Negative Regulation Of Translational Frameshifting Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Signaling by ALK Signaling by ALK MDK and PTN in ALK signaling MDK and PTN in ALK signaling	Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR1-mediated ceramide production Degradation of CDH1
Drugs			Copper
Diseases
GWAS		Aluminium levels ( 26025379) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood protein levels ( 30072576) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Schizophrenia ( 25056061 29483656)
Interacting Genes		101 interacting genes: ACTB ALK APOBEC3G ARIH2 ARL15 ASPH ATP5F1C ATRX BAG6 BARD1 BCCIP BCL2L1 BLOC1S1 BMI1 BTBD2 C11orf58 C7orf25 CAAP1 CACNB4 CAPZB CDH10 CDK5RAP2 CGA CHD3 COX6C CRCT1 CRELD1 CSTA CYP2E1 DNAJB11 DUSP12 EIF3F EVA1A FEZ1 FTL GADD45A GADD45G GIPC2 GLYAT GPD1 GPRASP2 GSDME GSK3B GSTP1 GTF2F1 HGH1 HSPBAP1 ITSN2 KPNB1 LAMA4 LUC7L2 MAD2L1BP MFRP MKKS MLLT3 MRPL44 MYCBP NAP1L5 NCAN NEK6 NUDT21 P4HB PFDN1 PIAS4 PLXNB2 PMF1 PPP2CA PSMB10 PSMD11 PSMD2 PTPRS PTPRZ1 RACK1 RBM23 RIT1 RNF167 ROR1 RPLP1 SAT1 SDC1 SDC3 SGSM2 SGTA SLC25A36 SNCAIP SPIN1 SSR1 STC2 SUPT7L TAC3 TAF1D TBRG4 TOMM20 TP53BP2 TSC22D1 TXNDC9 UBQLN1 UBQLN4 UTP3 WASHC3 WFDC2	112 interacting genes: ACTN2 ADH1B ADRB2 AGTRAP AR ARRDC3 ATG14 ATG5 AURKB BCL2L11 BECN1 BIRC6 BRCA1 CCNA1 CDKN1A CHERP CLEC1B CNOT2 CRMP1 CSF2RB DDX19B DNM1 DYNLL1 EED EIF6 ELOB EP300 EPOR ESR1 ESS2 FYN GABRB3 GATA4 GGN GNB1 GOLM1 GPBP1 GRAP2 GRIN2B HABP4 HIF1A HNRNPH2 IFNAR1 IFNAR2 IGF1R IK IL2RB IL4R IL7R INSR ITGB1 ITGB2 ITGB5 ITGB7 JAK1 KLHL20 LRP12 MAPK6 MCPH1 MKRN2 MTNR1A NFATC1 NR3C1 NSMAF OLA1 PABPC1 PDE4D PIK3R4 PLCG1 PLEC PRKAA1 PRKAB2 PRKAR2A PRKCA PRKCB PRKCD PRKCE PRKD1 PRPF31 PTN PTOV1 PTPRM RASA1 RASA3 RB1 RHOA SAT1 SLC27A6 SLC6A3 SLC9A5 SRC SREK1 ST7 STAT1 STAT3 SUMO4 SYT1 TARDBP TBXA2R TENM1 TMEM131 TNFRSF1A TP63 TP73 TSC22D4 TUBB TUBG1 TYK2 USP40 USP54 WDR83 ZSCAN12
Entrez ID		5764	10399
HPRD ID		01199	01503
Ensembl ID		ENSG00000105894	ENSG00000204628
Uniprot IDs		A0A8V8TNI1 P21246	E9KL35 P63244
PDB IDs		2N6F 8VOH 8VOI	4AOW 4UG0 4V5Z 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7NWH 7QP6 7QP7 7R4X 7TQL 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Stress	Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Receptor Complex Regulation Of Intracellular Signal Transduction Protein Kinase Binding Plasma Membrane Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization Regulation Of Programmed Cell Death Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Developmental Process Regulation Of Apoptotic Process Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Angiogenesis Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Process Positive Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Vasculature Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Biological Quality Intracellular Signaling Cassette Cellular Response To Hormone Stimulus Negative Regulation Of Apoptotic Process Regulation Of Developmental Process Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Reactive Oxygen Species Metabolic Process Transcription Corepressor Binding Phosphorylation Developmental Process Enzyme Binding Positive Regulation Of Cellular Component Organization Identical Protein Binding Regulation Of Glycolytic Process Protein Phosphorylation Cytoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Transport Regulation Of Protein Localization Negative Regulation Of Intracellular Signal Transduction Response To Hormone
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