TTBK2 and KLHL12

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		TTBK2	KLHL12
Description		tau tubulin kinase 2	kelch like family member 12
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Ciliary Transition Zone Ciliary Basal Body Cell Projection Ciliary Base	Cytoplasm Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinesin Binding Tau Protein Binding Tau-protein Kinase Activity Microtubule Plus-end Binding Protein Serine Kinase Activity	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Signal Transduction Smoothened Signaling Pathway Intracellular Protein Localization Regulation Of Smoothened Signaling Pathway Peptidyl-serine Phosphorylation Cerebellum Development Cerebellar Granular Layer Development Neural Tube Development Cerebellar Granule Cell Precursor Tangential Migration Cell Projection Organization Regulation Of Cell Migration Forebrain Development Protein Localization To Organelle Embryonic Digit Morphogenesis Cilium Assembly Negative Regulation Of Protein Localization To Microtubule Positive Regulation Of Non-motile Cilium Assembly Negative Regulation Of Protein Localization Embryonic Brain Development	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Anatomical Structure Morphogenesis Tissue Development Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway Vesicle-mediated Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process COPII Vesicle Coating
Pathways		Anchoring of the basal body to the plasma membrane	Degradation of DVL
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Bipolar disorder ( 31043756) Hematocrit ( 32888494) MGMT methylation in smokers ( 26183928)
Interacting Genes		1 interacting genes: KLHL12	58 interacting genes: ARAF ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KEAP1 KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDCD6 PDGFRB PEA15 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4
Entrez ID		146057	59349
HPRD ID		10288	13925
Ensembl ID		ENSG00000128881	ENSG00000117153
Uniprot IDs		Q6IQ55 Q8IWY7	Q53G59 Q9H7R2
PDB IDs		6U0K 6VRF 7O3B 7Q8Y 7Q8Z 7Q90	2VPJ 6TTK 6V7O 8OIO 8RBH
Enriched GO Terms of Interacting Partners?			Cul3-RING Ubiquitin Ligase Complex Protein Binding Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Identical Protein Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Modification Process POZ Domain Binding Proteolysis Involved In Protein Catabolic Process Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signaling Actin Cytoskeleton Organization Positive Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Positive Regulation Of Organelle Organization Cytoskeleton Organization Actin Filament-based Process Paraspeckles Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Component Assembly Regulation Of Locomotion Positive Regulation Of Locomotion
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