CSN1S1 and HTRA2

Number of citations of the paper that reports this interaction (PubMedID 10971580)
0

Data Source:
HPRD (in vitro)

		CSN1S1	HTRA2
Description		casein alpha s1	HtrA serine peptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane Protein-containing Complex CD40 Receptor Complex Serine-type Endopeptidase Complex
	Molecular Function	Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Unfolded Protein Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Response To Estradiol Response To Progesterone Response To Dehydroepiandrosterone Response To 11-deoxycorticosterone	Proteolysis Ceramide Metabolic Process Apoptotic Process Mitochondrion Organization Adult Walking Behavior Adult Locomotory Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Programmed Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Protein Catabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Intracellular Signal Transduction Mitochondrial Protein Catabolic Process Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Neuron Development Neuron Apoptotic Process Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Type 2 Mitophagy Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Miscellaneous transport and binding events	Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases			Parkinson's disease (PD)
GWAS
Interacting Genes		11 interacting genes: CSNK2A1 CSNK2B HTRA2 PARK7 PLK1 PPM1J PRSS2 STK4 TOLLIP TTBK1 UBQLN2	41 interacting genes: ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 IMMT ITGA7 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MUL1 PAG1 PDXDC1 PDXDC2P-NPIPB14P PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P UBC USP7 VIM VPS4B XIAP
Entrez ID		1446	27429
HPRD ID		00280	05919
Ensembl ID		ENSG00000126545	ENSG00000115317
Uniprot IDs		P47710	A0A384MDW9 A0A8Q3SIX7 O43464
PDB IDs			1LCY 2PZD 5FHT 5M3N 5M3O 5TNY 5TNZ 5TO0 5TO1 5WYN 7VGE 8AUK 8E2K
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Regulation Of Protein Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Proteolysis Protein Serine/threonine Kinase Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Autophagy Identical Protein Binding PML Body Protein Serine Kinase Activity Negative Regulation Of Protein Catabolic Process Regulation Of Protein Stability Regulation Of Autophagy Negative Regulation Of Catabolic Process Phosphorylation Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Sumoylation Positive Regulation Of Apoptotic Signaling Pathway Execution Phase Of Apoptosis Protein Localization To Site Of Double-strand Break PcG Protein Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Kinase Activity Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Macroautophagy Regulation Of Cellular Response To Stress Positive Regulation Of Protein Catabolic Process Positive Regulation Of Catabolic Process Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Peptidyl-serine Phosphorylation Macromolecule Metabolic Process Wnt Signaling Pathway Protein Localization To Organelle Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Growth Negative Regulation Of DNA Recombination Protein Stabilization Kinase Activity	Cell Death Apoptotic Process Programmed Cell Death MAP Kinase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process MAPK Cascade Regulation Of Cell Cycle Ubiquitin-protein Transferase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Cytosol Intracellular Signal Transduction Ubiquitin Protein Ligase Activity Protein Kinase Activity Regulation Of Apoptotic Process Intracellular Signaling Cassette Structural Constituent Of Cytoskeleton Regulation Of Programmed Cell Death Response To Cytokine Response To Peptide Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Inflammatory Response Acetylcholine Receptor Activator Activity Cytoplasm Response To Light Stimulus Positive Regulation Of Post-translational Protein Modification Glial Cell Development Protein Serine Kinase Activity Post-translational Protein Modification Regulation Of Post-translational Protein Modification Nucleotide Binding P38MAPK Cascade Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Protein Serine/threonine Kinase Activity Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Growth Regulation Of Synapse Organization Response To Radiation DNA Damage Response Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Developmental Growth Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Modification Process
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