CSN1S1 and PLK1

Number of citations of the paper that reports this interaction (PMID 7790358)
113

Data Source:
BioGRID (enzymatic study)

		CSN1S1	PLK1
Gene Name		casein alpha s1	polo-like kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Kinetochore Spindle Pole Condensed Nuclear Chromosome Outer Kinetochore Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Spindle Cytosol Spindle Microtubule Microtubule Cytoskeleton Midbody Spindle Midzone
	Molecular Function	Transporter Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Anaphase-promoting Complex Binding Kinase Activity Protein Kinase Binding
	Biological Process	Transport	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Mitotic Cytokinesis Cytokinesis Microtubule Bundle Formation Protein Phosphorylation Organelle Organization Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Metaphase/anaphase Transition Of Mitotic Cell Cycle Activation Of APC-Cdc20 Complex Activity Mitotic Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Cell Proliferation Positive Regulation Of Peptidyl-threonine Phosphorylation Protein Ubiquitination Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G2 DNA Damage Checkpoint Protein Destabilization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Polar Body Extrusion After Meiotic Divisions Negative Regulation Of Apoptotic Process Regulation Of Protein Binding Establishment Of Protein Localization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Proteolysis Response To Antibiotic Centrosome Organization Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Protein Localization To Chromatin
Pathways			Phosphorylation of the APC/C Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Organelle biogenesis and maintenance Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown G2/M Transition Mitotic Metaphase/Anaphase Transition Phosphorylation of Emi1 Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition M Phase Cyclin A/B1 associated events during G2/M transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Assembly of the primary cilium Regulation of APC/C activators between G1/S and early anaphase Anchoring of the basal body to the plasma membrane APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Centrosome maturation Condensation of Prophase Chromosomes Mitotic G2-G2/M phases Polo-like kinase mediated events Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CSNK2A1 CSNK2B HTRA2 PARK7 PLK1 PPM1J PRSS2 SAP130 STK4 TOLLIP TTBK1	99 interactors: ACTL6B APP ASPM BAG6 BIRC6 BRCA2 BUB1 C6orf136 C9orf114 CCDC115 CCNB1 CDC20 CDC25C CENPQ CENPU CEP55 CHEK2 CIC CPSF3L CSN1S1 CSN2 CTNNB1 DNAJB9 DNHD1 ECT2 EIF6 FBXL5 FLJ20712 FZR1 GET4 GLB1 GORASP1 HSF1 IKBKB ITSN1 KIF23 KLHL22 KRBA1 LMO4 LRP5L MAGED1 MAPK6 MCM2 MCM3 MCM7 MDM2 MPP2 MYT1 NEDD4 NINL NPM1 NUDC OFD1 PHC2 PIN1 PITPNM1 PKMYT1 PPID PRC1 PSMA1 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 RABAC1 RAP1GAP RBX1 RECQL5 RELA RNF126 RXRA SIMC1 SNCA SNCB STAG2 SUGT1 TANK TNFSF11 TP53 TP53BP1 TP53BP2 TPT1 TRIOBP TSC1 TUBA4A TUBB TUBB3 TUBG1 VRK3 WEE1 ZNF71
Entrez ID		1446	5347
HPRD ID		00280	03652
Ensembl ID		ENSG00000126545	ENSG00000166851
Uniprot IDs		P47710	P53350
PDB IDs			1Q4K 1Q4O 1UMW 2OGQ 2OJX 2OU7 2OWB 2RKU 2V5Q 2YAC 3BZI 3C5L 3FC2 3FVH 3HIH 3HIK 3KB7 3P2W 3P2Z 3P34 3P35 3P36 3P37 3Q1I 3RQ7 3THB 4A4L 4A4O 4DFW 4E67 4E9C 4E9D 4H5X 4H71 4HAB 4HCO 4HY2 4J52 4J53
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Binding Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Peptidyl-serine Phosphorylation Positive Regulation Of Protein Modification Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Binding Regulation Of Protein Sumoylation Peptidyl-amino Acid Modification Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Toxic Substance Negative Regulation Of Oxidative Stress-induced Cell Death Phosphorylation Phosphate-containing Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Growth Positive Regulation Of Signal Transduction Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Proteolysis Protein Phosphorylation Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Cell Death Positive Regulation Of Protein Binding Positive Regulation Of Cellular Metabolic Process	Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Signal Transduction By P53 Class Mediator Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic G1 DNA Damage Checkpoint Negative Regulation Of Cellular Metabolic Process Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Arrest Positive Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Mitotic DNA Integrity Checkpoint Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Positive Regulation Of Protein Ubiquitination Negative Regulation Of Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Proteasomal Protein Catabolic Process DNA Damage Checkpoint
Tagcloud ?		0x 1x 25x 2x 4ebp1 4x 5x 8x arg arginine bovine casein conditionally csn2 csn3 devoid except excess experimental gland mammary mtor output resemble s6k stat5 true	53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic properly recombination rnf168 rnf8 s1618 spatiotemporally ubiquitinated
Tagcloud (Difference) ?		0x 1x 25x 2x 4ebp1 4x 5x 8x arg arginine bovine casein conditionally csn2 csn3 devoid except excess experimental gland mammary mtor output resemble s6k stat5 true	53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic properly recombination rnf168 rnf8 s1618 spatiotemporally ubiquitinated
Tagcloud (Intersection) ?