CPNE8 and SORBS3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CPNE8	SORBS3
Description		copine 8	sorbin and SH3 domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Extracellular Exosome	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell-substrate Junction Anchoring Junction
	Molecular Function	Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding	Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding
	Biological Process	Cellular Response To Calcium Ion Positive Regulation Of Dendrite Extension	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Cytoskeleton Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways		CDC42 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle	Smooth Muscle Contraction
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Arterial stiffness index ( 31235810) Bipolar disorder ( 28115744) Bisphosphonate-associated atypical femoral fracture ( 31006051) Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 25673413) Body size at age 10 ( 32376654) Chronotype ( 30696823) Heart rate ( 23583979) Heart rate response to recovery post exercise ( 29769521) Irritable bowel syndrome ( 29626450) Morning person ( 30696823) Resting heart rate ( 29769521)	Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)
Interacting Genes		3 interacting genes: NECAB1 NEIL3 SORBS3	137 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AIRIM AKIRIN2 AKT2 ANKS1A ARNT2 ATOSB CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CFTR CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DRC4 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM53C FASLG FBXL19 FLOT1 FNDC11 FXR1 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SHANK3 SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSC1 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414
Entrez ID		144402	10174
HPRD ID		16747	11535
Ensembl ID		ENSG00000139117	ENSG00000120896
Uniprot IDs		Q86YQ8	O60504
PDB IDs			2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Depurination MCM Complex Binding Positive Regulation Of Potassium Ion Export Across Plasma Membrane Activation Of Blood Coagulation Via Clotting Cascade Calcium Activated Phosphatidylserine Scrambling Calcium Activated Phospholipid Scrambling Calcium Activated Phosphatidylcholine Scrambling Phosphatidylserine Exposure On Blood Platelet Vinculin Binding Cell-substrate Junction Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Bubble DNA Binding Single Strand Break Repair DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity DNA N-glycosylase Activity Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Negative Regulation Of Cell Volume Calcium-activated Cation Channel Activity Regulation Of Potassium Ion Export Across Plasma Membrane Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Chloride Channel Activity Positive Regulation Of Phagocytosis, Engulfment Bleb Assembly Base-excision Repair, AP Site Formation Intracellularly Calcium-gated Chloride Channel Activity Regulation Of Amyloid Precursor Protein Biosynthetic Process Phospholipid Scramblase Activity Pore Complex Assembly Plasma Membrane Phospholipid Scrambling Positive Regulation Of Monocyte Chemotaxis Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Blastocyst Hatching Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Blood Coagulation DNA Modification Positive Regulation Of Coagulation Regulation Of Monocyte Chemotaxis Positive Regulation Of Potassium Ion Transport	Protein Binding Cytoskeleton Cytoplasm SH3 Domain Binding Adherens Junction Organization Adherens Junction Assembly Regulation Of Actin Cytoskeleton Organization Identical Protein Binding Regulation Of Actin Filament Organization Bergmann Glial Cell Differentiation Regulation Of Actin Filament-based Process Motile Cilium Zonula Adherens Assembly Protein Domain Specific Binding Regulation Of Cytoskeleton Organization Positive Regulation Of Cap-dependent Translational Initiation Interleukin-34-mediated Signaling Pathway Nucleus Glial Cell Differentiation Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase III Regulation Of Golgi Inheritance Centriole Cell Projection
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