CRYGS and TINF2

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		CRYGS	TINF2
Description		crystallin gamma S	TERF1 interacting nuclear factor 2
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GO Annotations	Cellular Component		Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding	DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Morphogenesis Of An Epithelium Lens Development In Camera-type Eye Visual Perception	Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases			Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Glaucoma (primary open-angle) ( 29449654) Illicit drug use ( 23942779) Open-angle glaucoma and vertical cup-disc ratio ( 29449654)	Leukocyte telomere length ( 31171785) Platelet count ( 29403010)
Interacting Genes		4 interacting genes: CRYAB POT1 TERF2IP TINF2	91 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CSNK2A1 CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TFRC TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		1427	26277
HPRD ID		00439	16056
Ensembl ID		ENSG00000213139	ENSG00000092330
Uniprot IDs		A0A140CTX8 P22914	B4DFJ1 Q9BSI4
PDB IDs		1HA4 2M3T 2M3U 6FD8 6IF9 7N36 7N37 7N38 7N39 7N3A 7N3B 7NJE	3BQO 3BU8 5XYF
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process G-rich Strand Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Cellular Component Organization Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Positive Regulation Of DNA Metabolic Process Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Positive Regulation Of DNA Strand Elongation Chromosome Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Protein Localization To Chromosome DNA Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Telomeric Loop Disassembly Regulation Of Double-strand Break Repair Perinucleolar Chromocenter Negative Regulation Of DNA Recombination At Telomere Organelle Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding	Cytosol Extracellular Exosome Cytoplasm ADP Metabolic Process Purine Ribonucleotide Catabolic Process Ribonucleoside Diphosphate Metabolic Process Glycolytic Process ADP Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Phosphate Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Cadherin Binding Pyruvate Metabolic Process Nucleotide Catabolic Process Carbohydrate Catabolic Process Shelterin Complex Organophosphate Catabolic Process Glucose Metabolic Process RNA-templated DNA Biosynthetic Process Nuclear Telomere Cap Complex Glucose Catabolic Process Nucleobase-containing Compound Catabolic Process Protein Localization To Chromosome, Telomeric Region ATP Metabolic Process Hexose Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Capping Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy Ficolin-1-rich Granule Lumen Nucleobase-containing Small Molecule Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Phosphoglucomutase Activity Nucleoside Metabolic Process Protein Binding Purine Ribonucleotide Metabolic Process Calcium-dependent Phospholipid Binding Cellular Response To Heat Canonical Glycolysis Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribonucleotide Metabolic Process Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate
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