HSPA2

Name	heat shock protein family A (Hsp70) member 2
Structure
Interactors	14 interactors: APP BAG4 CDK1 CRBN EWSR1 FTCD HSPBP1 MAP3K3 MEOX2 PARP1 RNF144A SAE1 TRIM38 UBE3A
GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Cell Surface Membrane CatSper Complex Extracellular Exosome Blood Microparticle Meiotic Spindle
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Protein Folding Chaperone Tau Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding Glycolipid Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Protein Folding Response To Unfolded Protein Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Spermatid Development Response To Heat Response To Cold Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Protein Refolding Synaptonemal Complex Disassembly Negative Regulation Of Inclusion Body Assembly
Pathways	Meiotic synapsis Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase PKR-mediated signaling
Drugs	Quercetin
GWAS	Appendicular lean mass ( 33097823 )
Entrez ID	3306
HPRD ID	07174
Ensembl ID	ENSG00000126803
Uniprot IDs	P54652
PDB IDs	3I33 4FSV 5FPD 5FPE 5FPM 5FPN
GO Terms Enriched among Interactors ?	Post-translational Protein Modification Protein Modification Process Regulation Of Protein Localization Regulation Of Circadian Rhythm Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cytoplasm Positive Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Adenyl-nucleotide Exchange Factor Activity Transferase Activity Protein Localization To Site Of Double-strand Break Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization Response To Copper Ion NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Response To Nerve Growth Factor Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Amyloid-beta NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Establishment Of Protein Localization Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Toll Signaling Pathway Pronuclear Fusion Limb Development Sperm Entry Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Golgi Lumen Acidification Negative Regulation Of MRNA Modification Regulation Of Protein Targeting To Mitochondrion Protein Sumoylation Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity Modification-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Regulation Of Primary Metabolic Process Response To Amyloid-beta Positive Regulation Of Macromolecule Metabolic Process