HSPA2 and SAE1

Number of citations of the paper that reports this interaction (PubMedID 25027693)
0

Data Source:
BioGRID (enzymatic study)

		HSPA2	SAE1
Description		heat shock protein family A (Hsp70) member 2	SUMO1 activating enzyme subunit 1
Image
GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Cell Surface Membrane CatSper Complex Extracellular Exosome Blood Microparticle Meiotic Spindle	Nucleus Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Protein Folding Chaperone Tau Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding Glycolipid Binding ATP-dependent Protein Folding Chaperone	Ubiquitin Activating Enzyme Activity Protein Binding Enzyme Activator Activity Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Small Protein Activating Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Protein Folding Response To Unfolded Protein Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Spermatid Development Response To Heat Response To Cold Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Protein Refolding Synaptonemal Complex Disassembly Negative Regulation Of Inclusion Body Assembly	Protein Ubiquitination Protein Sumoylation Positive Regulation Of Protein Sumoylation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Meiotic synapsis Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase PKR-mediated signaling	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs		Quercetin
Diseases
GWAS		Appendicular lean mass ( 33097823)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 21833088 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) White blood cell count ( 27863252 32888494)
Interacting Genes		14 interacting genes: APP BAG4 CDK1 CRBN EWSR1 FTCD HSPBP1 MAP3K3 MEOX2 PARP1 RNF144A SAE1 TRIM38 UBE3A	22 interacting genes: AGTR1 APP CEBPA CRX ERCC6 ETV4 HSPA1A HSPA2 IL3RA MEOX2 NFYC PAX5 PAX6 PAX8 PTK2 SUMO2 SUMO3 UBA2 UBD UBE2E3 UBE2I USP39
Entrez ID		3306	10055
HPRD ID		07174	18010
Ensembl ID		ENSG00000126803	ENSG00000142230
Uniprot IDs		P54652	Q9UBE0
PDB IDs		3I33 4FSV 5FPD 5FPE 5FPM 5FPN	1Y8Q 1Y8R 3KYC 3KYD 6CWY 6CWZ 6XOG 6XOH 6XOI 8VY5
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Regulation Of Protein Localization Regulation Of Circadian Rhythm Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cytoplasm Positive Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Adenyl-nucleotide Exchange Factor Activity Transferase Activity Protein Localization To Site Of Double-strand Break Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization Response To Copper Ion NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Response To Nerve Growth Factor Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Amyloid-beta NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Establishment Of Protein Localization Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Toll Signaling Pathway Pronuclear Fusion Limb Development Sperm Entry Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Golgi Lumen Acidification Negative Regulation Of MRNA Modification Regulation Of Protein Targeting To Mitochondrion Protein Sumoylation Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity Modification-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Regulation Of Primary Metabolic Process Response To Amyloid-beta Positive Regulation Of Macromolecule Metabolic Process	Positive Regulation Of Transcription By RNA Polymerase II Nucleus Protein Sumoylation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Proteolysis Post-translational Protein Modification Positive Regulation Of Cell Differentiation Nucleoplasm Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Modification By Small Protein Conjugation Small Protein Activating Enzyme Binding Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Biosynthetic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Protein Heterodimerization Activity Regulation Of RNA Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Epithelial Cell Differentiation Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis HMG Box Domain Binding Protein Modification Process Negative Regulation Of Inclusion Body Assembly Macromolecule Metabolic Process DNA Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Developmental Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity DNA-templated Transcription Sequence-specific DNA Binding Chromatin Binding SUMO Transferase Activity
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