HSPA2 and HSPBP1

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, cross-linking study)
HPRD (two hybrid)

		HSPA2	HSPBP1
Description		heat shock protein family A (Hsp70) member 2	HSPA (Hsp70) binding protein 1
Image
GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Cell Surface Membrane CatSper Complex Extracellular Exosome Blood Microparticle Meiotic Spindle	Extracellular Space Endoplasmic Reticulum
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Protein Folding Chaperone Tau Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding Glycolipid Binding ATP-dependent Protein Folding Chaperone	Adenyl-nucleotide Exchange Factor Activity Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding Molecular Sequestering Activity
	Biological Process	Protein Folding Response To Unfolded Protein Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Spermatid Development Response To Heat Response To Cold Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Protein Refolding Synaptonemal Complex Disassembly Negative Regulation Of Inclusion Body Assembly	Protein Folding Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Meiotic synapsis Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase PKR-mediated signaling
Drugs		Quercetin
Diseases
GWAS		Appendicular lean mass ( 33097823)	Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		14 interacting genes: APP BAG4 CDK1 CRBN EWSR1 FTCD HSPBP1 MAP3K3 MEOX2 PARP1 RNF144A SAE1 TRIM38 UBE3A	14 interacting genes: APP CLK1 EFEMP2 HSPA1A HSPA1B HSPA2 HSPA4 HSPA5 HSPA8 HSPA9 KRT27 LRIF1 NOTCH2NLA PTEN
Entrez ID		3306	23640
HPRD ID		07174	09991
Ensembl ID		ENSG00000126803	ENSG00000133265
Uniprot IDs		P54652	Q9NZL4
PDB IDs		3I33 4FSV 5FPD 5FPE 5FPM 5FPN	1XQR 1XQS 8X87
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Regulation Of Protein Localization Regulation Of Circadian Rhythm Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cytoplasm Positive Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Adenyl-nucleotide Exchange Factor Activity Transferase Activity Protein Localization To Site Of Double-strand Break Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization Response To Copper Ion NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Response To Nerve Growth Factor Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Amyloid-beta NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Establishment Of Protein Localization Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Toll Signaling Pathway Pronuclear Fusion Limb Development Sperm Entry Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Golgi Lumen Acidification Negative Regulation Of MRNA Modification Regulation Of Protein Targeting To Mitochondrion Protein Sumoylation Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity Modification-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Regulation Of Primary Metabolic Process Response To Amyloid-beta Positive Regulation Of Macromolecule Metabolic Process	ATP-dependent Protein Folding Chaperone Protein Refolding Protein Folding Chaperone Heat Shock Protein Binding Protein Folding Enzyme Binding Unfolded Protein Binding C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity Negative Regulation Of Inclusion Body Assembly ATP Hydrolysis Activity G Protein-coupled Receptor Binding Extracellular Exosome Regulation Of Inclusion Body Assembly Response To Unfolded Protein Protein-folding Chaperone Binding Regulation Of Protein Import Blood Microparticle Ubiquitin Protein Ligase Binding ATP Binding Regulation Of Erythrocyte Differentiation Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Negative Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Proteolysis Nucleotide Binding Positive Regulation Of Microtubule Nucleation Cellular Response To Steroid Hormone Stimulus Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Heat Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Misfolded Protein Binding Inclusion Body Regulation Of Microtubule Nucleation Ficolin-1-rich Granule Lumen Receptor Ligand Activity Chaperone-mediated Protein Complex Assembly Regulation Of Mitotic Spindle Assembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Cell Population Proliferation Regulation Of Proteolysis Regulation Of Supramolecular Fiber Organization Response To Temperature Stimulus Regulation Of Cellular Component Organization Regulation Of Extrinsic Apoptotic Signaling Pathway
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