HSPA2 and HSPBP1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)
HPRD (two hybrid)

		HSPA2	HSPBP1
Gene Name		heat shock 70kDa protein 2	HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
Image
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Mitochondrion Cytosol Cell Surface Membrane CatSper Complex Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding ATP Binding Enzyme Binding Unfolded Protein Binding Glycolipid Binding	Enzyme Inhibitor Activity Protein Binding
	Biological Process	Response To Unfolded Protein Male Meiosis Male Meiosis I Spermatid Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G2/M Transition Of Mitotic Cell Cycle Protein Refolding Synaptonemal Complex Disassembly Negative Regulation Of Inclusion Body Assembly	Protein Folding Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catalytic Activity
Pathways		HSF1-dependent transactivation Attenuation phase Meiotic synapsis Cellular response to heat stress Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: APP CDK1 EWSR1 HSPBP1 MAP3K3 MEOX2 PARP1 SAE1 TRIM38	10 interactors: APP HSPA1A HSPA1B HSPA2 HSPA4 HSPA5 HSPA8 HSPA9 LRIF1 NOTCH2NL
Entrez ID		3306	23640
HPRD ID		07174	09991
Ensembl ID		ENSG00000126803	ENSG00000133265
Uniprot IDs		P54652	Q9NZL4
PDB IDs		3I33 4FSV	1XQR 1XQS
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Proteolysis Cellular Protein Metabolic Process Activation Of MAPKK Activity Neuron Death Cellular Protein Modification Process Pronuclear Fusion Regulation Of Mitotic Cell Cycle Response To Oxidative Stress Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Import Into Nucleus Cellular Response To Reactive Oxygen Species Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Modification-dependent Protein Catabolic Process SMT3-dependent Protein Catabolic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of Signal Transduction Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Catalytic Activity Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Poly-ADP-ribosylation Collateral Sprouting In Absence Of Injury Regulation Of Growth Rate Positive Regulation Of Protein Ubiquitination Activation Of MAPK Activity Regulation Of Growth Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Protein Import Into Nucleus Regulation Of Signal Transduction Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process	Response To Unfolded Protein Protein Refolding Negative Regulation Of Inclusion Body Assembly Regulation Of Inclusion Body Assembly Protein Folding Regulation Of Cellular Response To Heat Cellular Heat Acclimation Cellular Response To Heat Response To Heat Positive Regulation Of Erythrocyte Differentiation MRNA Metabolic Process Response To Temperature Stimulus Regulation Of Protein Ubiquitination Regulation Of Erythrocyte Differentiation Response To Stress Viral Entry Into Host Cell Entry Into Host Cell Response To Organic Substance Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Targeting To Mitochondrion Negative Regulation Of Apoptotic Process Platelet Degranulation Negative Regulation Of Programmed Cell Death Protein Localization To Mitochondrion Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G2/M Transition Of Mitotic Cell Cycle Synaptonemal Complex Disassembly Negative Regulation Of Fibril Organization Regulation Of Protein Folding In Endoplasmic Reticulum Positive Regulation Of Myeloid Cell Differentiation Response To External Stimulus Cellular Protein Metabolic Process Negative Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Oxidative Stress Protein Stabilization Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Establishment Of Localization In Cell Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Protein Ubiquitination Interaction With Host Cerebellum Structural Organization Synaptic Growth At Neuromuscular Junction Secretion By Cell Protein Localization To Organelle Regulation Of Protein Metabolic Process Locomotion Collateral Sprouting In Absence Of Injury Regulation Of Fibril Organization Viral Process
Tagcloud ?		1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tac1 tmod1 xecd	accelerating associates bag biogenesis cftr cochaperone compartments conductance cystic deltaf508 export fibrosis folding hsc70 hsp105 hsp105alpha impairing inform interferes misfolded misfolding multilevel opportunities phe potently relates serves stabilizes super
Tagcloud (Difference) ?		1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tac1 tmod1 xecd	accelerating associates bag biogenesis cftr cochaperone compartments conductance cystic deltaf508 export fibrosis folding hsc70 hsp105 hsp105alpha impairing inform interferes misfolded misfolding multilevel opportunities phe potently relates serves stabilizes super
Tagcloud (Intersection) ?