ERCC6 and POLR2A

Number of citations of the paper that reports this interaction (PubMedID 9372911)
62

Data Source:
HPRD (in vitro)

		ERCC6	POLR2A
Description		ERCC excision repair 6, chromatin remodeling factor	RNA polymerase II subunit A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Transcription Elongation Factor Complex Nuclear Body Site Of DNA Damage B-WICH Complex	DNA-directed RNA Polymerase Complex Prp19 Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex Chromosome Nucleolus Cytoplasm
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Chromatin Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Protein Tyrosine Kinase Activator Activity Sequence-specific DNA Binding RNA Polymerase Binding Chromatin-protein Adaptor Activity ATP-dependent Chromatin Remodeler Activity ATP-dependent DNA Damage Sensor Activity	Magnesium Ion Binding Nucleic Acid Binding DNA Binding RNA Binding DNA-directed RNA Polymerase Activity RNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Kinase Binding Ubiquitin Protein Ligase Binding 5'-3' RNA Polymerase Activity Metal Ion Binding Microfibril Binding Promoter-specific Chromatin Binding
	Biological Process	Single Strand Break Repair DNA Damage Checkpoint Signaling Response To Superoxide Positive Regulation Of Defense Response To Virus By Host DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Pyrimidine Dimer Repair Chromatin Remodeling Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase II DNA Damage Response Response To Oxidative Stress JNK Cascade Nervous System Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Positive Regulation Of Gene Expression Protein Ubiquitination Neurogenesis Neuron Differentiation Neuron Projection Development Regulation Of DNA-templated Transcription Elongation Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Transcription Elongation By RNA Polymerase II Multicellular Organism Growth DNA Protection Photoreceptor Cell Maintenance Positive Regulation Of DNA Repair Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Transcription Initiation By RNA Polymerase II Protein Localization To Chromatin Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	RNA-templated Transcription DNA-templated Transcription DNA-templated Transcription Termination Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Positive Regulation Of Gene Expression Positive Regulation Of RNA Splicing MRNA Transcription By RNA Polymerase II
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER RNA Polymerase I Transcription Initiation	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cockayne syndrome Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)	Atrial fibrillation ( 29892015) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 29760442) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Myopia ( 27182965) Parkinson's disease progression (cognitive) ( 33958783) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		117 interacting genes: ACTR2 ACTR3 ARPC1A ATP5F1C ATP5PO CAVIN1 CCT5 CCT6A CHEK2 CLIC4 COPE CORO1C CSNK2A2 CSNK2B CTSB CUL5 DARS1 DCLRE1A ECHS1 EIF3C EIF3D EIF3F EIF3I EIF3L EIF4A3 ELOA ERCC5 ERCC8 FBLN2 FNDC3B FOSL1 FXR1 FYTTD1 GATAD2B GRPEL1 GTF2E2 GTF2I H2BC3 H3C1 H4C1 HDAC1 HDAC2 HNRNPUL2 HSPA5 HSPA9 HTATSF1 IARS2 IDH3G IWS1 LEO1 MBD3 MORC3 MRPL11 MRPL13 MRPL20 MRPL21 MRPL3 MRPL38 MRPL4 MRPL47 MRPL50 MRPL58 MRPS18B MRPS22 MRPS25 MRPS26 MTA1 MTA2 MTA3 NAP1L1 NONO NPLOC4 PAF1 PARP1 PCNA PFN2 PML POLR2A POLR2H PPIA PSMC5 RBBP7 RCC1 RHOG RNF11 RPL10 RPL13 RPL30 RPL39 RPL5 RPS15 RPS15A RPS24 RPS29 RPS6 SAE1 SDHA SENP2 SF3B3 SLC39A7 SNRPD1 SUMO1 SUMO2 SUPT6H TACO1 TP53 TPR UBA2 UBC UBE2I UQCRC1 UQCRQ USP7 XAB2 XPA XRCC5 ZBTB38	103 interacting genes: ABL1 ACTB ACTL6A ATM BARD1 BRCA1 CALCOCO1 CALCOCO2 CASP10 CCNH CCNK CCNL2 CCNT1 CDC14A CDK12 CDK8 CDK9 CPSF1 CPSF2 CPSF3 CREBBP CSH2 CSNK2A1 CSTF1 CSTF2 CTCF CTDP1 CTDSP1 CTDSP2 DHX9 EIF4ENIF1 ELL ERCC5 ERCC6 ERCC8 ERG ESR1 FUS GRB2 GTF2B GTF2H4 H1-2 HNRNPF HTATSF1 IFTAP ITCH IWS1 KAT2B KLK2 KMT2D LEO1 MCM3 MED21 MNAT1 MYH6 NEDD4 NONO NR0B2 NSD1 OTUD5 PCIF1 PHF8 PIN1 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2L PPIG PPP1CA PPP2CA PQBP1 PRMT5 PRPF19 PTEN RNF10 SAFB SKP2 SMN1 SMN2 SMURF1 SNAR-B2 SND1 SUB1 SUMO2 SUPT5H TAF10 TCEA1 TCERG1 TDRD3 TRAK1 TRAM2 TTK U2AF2 UBE2L3 UPF1 VDR XAB2 XRCC5 ZC3H4 ZNF74
Entrez ID		2074	5430
HPRD ID		00596	08916
Ensembl ID		ENSG00000225830	ENSG00000181222
Uniprot IDs		P0DP91 Q03468 Q59FF6	A0AAG2TJB2 P24928
PDB IDs		4CVO 6A6I 7OO3 7OOB 7OOP 7OPC 7OPD 8B3D 8B3F 9BZ0 9ER2 9FD2	2GHQ 2GHT 2LTO 3D9K 3D9L 3D9M 3D9N 3D9O 3D9P 4JXT 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5M3H 5M3J 6DRD 6F5P 6G0R 6IC8 6IC9 6O9L 6Q5Y 6XKB 6XRE 7EGB 7EGC 7LBM 7YCX 7Z1K 7Z42 8PM0 8PNP 8PNQ 8R3K 8R3L 8R60 8R65 9B9L 9EHZ 9EI1 9EI2 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		Translation Ribosome Macromolecule Metabolic Process RNA Binding Macromolecule Biosynthetic Process Structural Constituent Of Ribosome Ribonucleoprotein Complex Mitochondrial Translation Nucleoplasm Protein Metabolic Process NuRD Complex Mitochondrial Large Ribosomal Subunit Mitochondrial Inner Membrane Regulation Of Cell Fate Specification Regulation Of Cell Fate Commitment Nucleus Protein-RNA Complex Assembly Cytosolic Ribosome Ubiquitin Protein Ligase Binding Nucleic Acid Metabolic Process PML Body Regulation Of Stem Cell Differentiation Small Protein Activating Enzyme Binding Cytoplasmic Translation Formation Of Cytoplasmic Translation Initiation Complex Chromosome, Telomeric Region Eukaryotic Translation Initiation Factor 3 Complex Nucleobase-containing Compound Metabolic Process Eukaryotic 48S Preinitiation Complex Protein Sumoylation Mitochondrion Eukaryotic 43S Preinitiation Complex Cytoplasmic Translational Initiation Chromatin Organization Protein-containing Complex Nucleosomal DNA Binding Nucleolus DNA Repair Chromatin Remodeling Mitochondrial Ribosome Regulation Of Protein Metabolic Process Transcription-coupled Nucleotide-excision Repair Translational Initiation Nucleotide-excision Repair Protein-containing Complex Organization DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Protein-containing Complex Assembly Chromosome	Nucleoplasm Nucleic Acid Metabolic Process Nucleus RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Elongation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of DNA Metabolic Process DNA Repair Regulation Of Cell Cycle Regulation Of DNA Repair DNA Metabolic Process Regulation Of DNA-templated Transcription Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II MRNA Processing RNA Polymerase II, Core Complex DNA Damage Response Transcription Elongation By RNA Polymerase II Chromatin Binding Regulation Of Cell Cycle Process RNA Polymerase Binding Regulation Of Transcription Elongation By RNA Polymerase II Chromatin Organization Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle
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