ERCC6 and H3C1

Number of citations of the paper that reports this interaction (PubMedID 11003660)
68

Data Source:
BioGRID (far western blotting)

		ERCC6	H3C1
Description		ERCC excision repair 6, chromatin remodeling factor	H3 clustered histone 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Transcription Elongation Factor Complex Nuclear Body Site Of DNA Damage B-WICH Complex	Nucleosome Extracellular Region Nucleus Nucleoplasm Chromosome Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Chromatin Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Protein Tyrosine Kinase Activator Activity Sequence-specific DNA Binding RNA Polymerase Binding Chromatin-protein Adaptor Activity ATP-dependent Chromatin Remodeler Activity ATP-dependent DNA Damage Sensor Activity	DNA Binding Protein Binding Structural Constituent Of Chromatin Cadherin Binding Protein Heterodimerization Activity
	Biological Process	Single Strand Break Repair DNA Damage Checkpoint Signaling Response To Superoxide Positive Regulation Of Defense Response To Virus By Host DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Pyrimidine Dimer Repair Chromatin Remodeling Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase II DNA Damage Response Response To Oxidative Stress JNK Cascade Nervous System Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Positive Regulation Of Gene Expression Protein Ubiquitination Neurogenesis Neuron Differentiation Neuron Projection Development Regulation Of DNA-templated Transcription Elongation Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Transcription Elongation By RNA Polymerase II Multicellular Organism Growth DNA Protection Photoreceptor Cell Maintenance Positive Regulation Of DNA Repair Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Transcription Initiation By RNA Polymerase II Protein Localization To Chromatin Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Chromatin Organization Nucleosome Assembly Gene Expression Telomere Organization Epigenetic Regulation Of Gene Expression
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER RNA Polymerase I Transcription Initiation	Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cockayne syndrome Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		117 interacting genes: ACTR2 ACTR3 ARPC1A ATP5F1C ATP5PO CAVIN1 CCT5 CCT6A CHEK2 CLIC4 COPE CORO1C CSNK2A2 CSNK2B CTSB CUL5 DARS1 DCLRE1A ECHS1 EIF3C EIF3D EIF3F EIF3I EIF3L EIF4A3 ELOA ERCC5 ERCC8 FBLN2 FNDC3B FOSL1 FXR1 FYTTD1 GATAD2B GRPEL1 GTF2E2 GTF2I H2BC3 H3C1 H4C1 HDAC1 HDAC2 HNRNPUL2 HSPA5 HSPA9 HTATSF1 IARS2 IDH3G IWS1 LEO1 MBD3 MORC3 MRPL11 MRPL13 MRPL20 MRPL21 MRPL3 MRPL38 MRPL4 MRPL47 MRPL50 MRPL58 MRPS18B MRPS22 MRPS25 MRPS26 MTA1 MTA2 MTA3 NAP1L1 NONO NPLOC4 PAF1 PARP1 PCNA PFN2 PML POLR2A POLR2H PPIA PSMC5 RBBP7 RCC1 RHOG RNF11 RPL10 RPL13 RPL30 RPL39 RPL5 RPS15 RPS15A RPS24 RPS29 RPS6 SAE1 SDHA SENP2 SF3B3 SLC39A7 SNRPD1 SUMO1 SUMO2 SUPT6H TACO1 TP53 TPR UBA2 UBC UBE2I UQCRC1 UQCRQ USP7 XAB2 XPA XRCC5 ZBTB38	176 interacting genes: AIRE AKT2 ANAPC11 ANP32A ANP32B ASH1L ASH2L ATXN1 AURKA AURKB AURKC BARD1 BCAS3 BRCA1 CARM1 CBX1 CBX2 CBX3 CBX4 CBX5 CBX6 CBX7 CBX8 CDC20 CDYL CDYL2 CENPM CENPT CENPW CHD4 CHUK COPS2 CREBBP CTCFL CUL4A DCAF1 DDB1 DIDO1 DNMT3B DPF2 DTX2 DYRK1A EED EHMT1 EHMT2 EID1 EP300 ERCC6 ESCO1 EZH2 FANCD2 FBLIM1 GATAD2A GATAD2B GLYR1 GRIP1 H1-2 H4C14 HASPIN HAT1 HDAC1 HDAC2 HDAC3 HDAC5 HDAC8 HDGFL3 HNF1B HNRNPA1 HNRNPAB HPF1 HSPA8 ING4 JMJD6 KAT14 KAT2A KAT2B KAT5 KAT6A KAT6B KAT7 KAT8 KDM1A KDM2B KDM4A KDM4C KDM5A KDM6A KDM6B KDM8 KMT2A KMT2B KMT2C KMT2D L3MBTL2 L3MBTL3 MAD2L1 MBD5 MLLT3 MORF4L1 MPHOSPH8 MSL3 MYB NCOR1 NR1H4 NR3C1 NSD1 NSD2 NSD3 PAF1 PAK1 PALB2 PARP10 PARP2 PAXIP1 PBRM1 PHF1 PHF19 PHF20 PHF8 PIAS1 PIKFYVE PPM1D PPP1CA PPP1CB PRDM2 PRKCA PRKCB PRMT1 PRMT7 PWWP3B RAD51B RAG1 RBBP4 RBBP7 RCC1 RNF138 RPS6KA3 SETD1A SETD1B SETD2 SETD7 SETDB1 SF3B1 SHPRH SIRT1 SIRT2 SIRT3 SIRT6 SIRT7 SMARCA2 SMARCA5 SMYD5 SUPT16H SUV39H1 SUV39H2 TAF15 TAF1A TAF1B TAF3 THAP7 TLE3 TMEM132D TRIM24 TRIM33 TSPYL2 TSPYL5 TSSK6 UBR7 UHRF1 UHRF2 USP7 WDR5 WWC1 YEATS4 YWHAB YWHAG
Entrez ID		2074	8350
HPRD ID		00596	04155
Ensembl ID		ENSG00000225830	ENSG00000275714
Uniprot IDs		P0DP91 Q03468 Q59FF6	P68431
PDB IDs		4CVO 6A6I 7OO3 7OOB 7OOP 7OPC 7OPD 8B3D 8B3F 9BZ0 9ER2 9FD2	1CS9 1CT6 1O9S 1Q3L 2B2T 2B2U 2B2V 2B2W 2C1J 2C1N 2CO0 2CV5 2FSA 2KWJ 2KWK 2L75 2LBM 2LGG 2M0O 2NDF 2NDG 2OQ6 2OT7 2OX0 2RI7 2RR4 2UXN 2V85 2V89 2VNF 2VPG 2X0L 3A1B 3AFA 3AVR 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3B95 3FDT 3KMT 3KQI 3LQI 3LQJ 3MP1 3O34 3O35 3O37 3QJ6 3RIG 3RIY 3SOU 3SOW 3U31 3U3D 3U4S 3U5N 3U5O 3U5P 3UEE 3UEF 3UIG 3UII 3UIK 3V43 3W96 3W97 3W98 3W99 3WA9 3WAA 3WKJ 3X1S 3X1T 3X1U 3X1V 3ZG6 3ZVY 4A0J 4A0N 4A7J 4BD3 4C1Q 4F4U 4F56 4FWF 4HON 4I51 4L7X 4LK9 4LKA 4LLB 4LXL 4N4H 4QBQ 4QBR 4QBS 4TN7 4U68 4UP0 4UY4 4X3K 4Y6L 4YHP 4YHZ 4YM5 4YM6 4Z0R 4Z2M 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5B24 5B2I 5B2J 5B31 5C11 5C13 5C3I 5CPI 5CPJ 5CPK 5D6Y 5DAH 5FB0 5FB1 5FFV 5GH9 5GSE 5GSU 5GT0 5GT3 5GTC 5H6Q 5H6R 5HJB 5HJC 5HJD 5HYN 5IQL 5J3V 5J9S 5JHN 5JIN 5JIY 5JJ0 5JRG 5KJH 5KJI 5KKL 5LUG 5M5G 5MR8 5NNC 5NND 5OY3 5SVX 5SVY 5SZB 5SZC 5T0K 5T0M 5T1G 5T1I 5T8R 5TBN 5TDR 5TDW 5U2J 5V21 5V22 5VA6 5VAB 5VGE 5VNB 5WFC 5WLE 5WVO 5WXG 5WXH 5WYI 5X60 5XF3 5XF4 5XF5 5XFQ 5XFR 5XNV 5XTZ 5Y0C 5Y0D 5Y20 5Y2F 5Z23 5Z30 6AXJ 6AZE 6BHD 6BHE 6BHG 6BHH 6BHI 6D07 6D08 6E83 6E86 6F6D 6HKT 6HTS 6IEU 6IIS 6IIT 6IPU 6IQ4 6JOU 6JR0 6JR1 6JXD 6K1I 6K1J 6K1K 6KE9 6KVD 6L49 6L4A 6L9H 6L9Z 6LA2 6LA8 6LA9 6LAB 6LE9 6LER 6LS6 6LSD 6M3V 6M44 6M4D 6M4G 6M4H 6MIL 6MIM 6MIN 6MIO 6MIQ 6PA1 6PAG 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6T90 6T93 6UPK 6UPL 6USJ 6V2H 6V2K 6V3N 6V41 6V92 6VIL 6WAV 6WW4 6YIF 6YIH 6YOV 7BWD 7C0M 7CCQ 7CCR 7CFP 7CFQ 7COW 7D1Z 7DBP 7E8D 7EBK 7K5X 7K5Y 7K60 7K61 7K63 7KLR 7LBK 7LBO 7LBP 7LBQ 7LYA 7LYB 7LYC 7MJU 7NL0 7SCY 7SCZ 7TD5 7U0G 7U0I 7U0J 7V6Q 7V90 7V96 7V9C 7V9J 7V9K 7V9S 7VA4 7VZ4 7W9V 7X57 7X58 7XD1 7XVL 7XVM 7XX5 7XX6 7XZX 7XZY 7XZZ 7Y00 7Y5U 7Y5V 7Y5W 7Y60 7Y61 7Y7I 7Y8R 7YOZ 7YQK 7ZI4 8DK5 8DS8 8EVG 8EVH 8EVI 8EVJ 8GE0 8GRM 8GUI 8GUJ 8GUK 8H0V 8H0W 8H1T 8HAG 8HAH 8HAI 8HAJ 8HAK 8HAL 8HAM 8HAN 8HE5 8HLY 8HMX 8I60 8IEG 8IEJ 8IHL 8IIY 8IIZ 8IJ0 8IQF 8IQG 8J6S 8J6T 8JBX 8JCC 8JCD 8JHF 8JHG 8JL9 8JLA 8JND 8JNE 8JNF 8KCY 8KD1 8KE0 8OFF 8OO7 8OOA 8OOP 8OOS 8OSJ 8OSK 8OSL 8OTS 8OTT 8OX0 8OX1 8Q36 8Q3E 8Q3M 8Q3X 8QKT 8RGM 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8SPS 8SPU 8SWI 8SYP 8TXV 8TXW 8TXX 8U13 8U14 8UPF 8VFX 8VFY 8VFZ 8VG0 8VG1 8VG2 8VLR 8VMI 8VML 8VNV 8W9D 8W9E 8W9F 8WG5 8X15 8X19 8X1C 8XBT 8XBU 8XBW 8Y3C 8Y3D 8Y3E 8Y3F 8YBJ 8YBK 8YJF 8YJM 8YNY 8YTI 8YV8 9FGQ 9FH9 9J8M 9J8N 9J8O
Enriched GO Terms of Interacting Partners?		Translation Ribosome Macromolecule Metabolic Process RNA Binding Macromolecule Biosynthetic Process Structural Constituent Of Ribosome Ribonucleoprotein Complex Mitochondrial Translation Nucleoplasm Protein Metabolic Process NuRD Complex Mitochondrial Large Ribosomal Subunit Mitochondrial Inner Membrane Regulation Of Cell Fate Specification Regulation Of Cell Fate Commitment Nucleus Protein-RNA Complex Assembly Cytosolic Ribosome Ubiquitin Protein Ligase Binding Nucleic Acid Metabolic Process PML Body Regulation Of Stem Cell Differentiation Small Protein Activating Enzyme Binding Cytoplasmic Translation Formation Of Cytoplasmic Translation Initiation Complex Chromosome, Telomeric Region Eukaryotic Translation Initiation Factor 3 Complex Nucleobase-containing Compound Metabolic Process Eukaryotic 48S Preinitiation Complex Protein Sumoylation Mitochondrion Eukaryotic 43S Preinitiation Complex Cytoplasmic Translational Initiation Chromatin Organization Protein-containing Complex Nucleosomal DNA Binding Nucleolus DNA Repair Chromatin Remodeling Mitochondrial Ribosome Regulation Of Protein Metabolic Process Transcription-coupled Nucleotide-excision Repair Translational Initiation Nucleotide-excision Repair Protein-containing Complex Organization DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Protein-containing Complex Assembly Chromosome	Chromatin Organization Chromatin Remodeling Nucleoplasm Nucleus Chromatin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Heterochromatin Formation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Histone Binding Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Histone Methyltransferase Activity Transferase Activity Protein Modification Process Histone H3 Methyltransferase Activity Zinc Ion Binding Methyltransferase Activity DNA Damage Response Regulation Of DNA Metabolic Process Cellular Response To Stress Methylation Negative Regulation Of Gene Expression Histone Methyltransferase Complex
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