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ERCC6 and RPL10
Number of citations of the paper that reports this interaction (PubMedID
31722399
)
57
Data Source:
BioGRID
(affinity chromatography technology, pull down)
ERCC6
RPL10
Description
ERCC excision repair 6, chromatin remodeling factor
ribosomal protein L10
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Transcription Elongation Factor Complex
Nuclear Body
Site Of DNA Damage
B-WICH Complex
Nucleus
Cytoplasm
Endoplasmic Reticulum
Smooth Endoplasmic Reticulum
Cytosol
Ribosome
Membrane
Cytosolic Large Ribosomal Subunit
Cytosolic Ribosome
Protein-containing Complex
Ribonucleoprotein Complex
Molecular Function
Nucleotide Binding
DNA Binding
DNA Helicase Activity
Chromatin Binding
Helicase Activity
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
Hydrolase Activity
ATP Hydrolysis Activity
Protein Tyrosine Kinase Activator Activity
Sequence-specific DNA Binding
RNA Polymerase Binding
Chromatin-protein Adaptor Activity
ATP-dependent Chromatin Remodeler Activity
ATP-dependent DNA Damage Sensor Activity
RNA Binding
Structural Constituent Of Ribosome
Protein Binding
Translation Regulator Activity
Biological Process
Single Strand Break Repair
DNA Damage Checkpoint Signaling
Response To Superoxide
Positive Regulation Of Defense Response To Virus By Host
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Pyrimidine Dimer Repair
Chromatin Remodeling
Transcription Elongation By RNA Polymerase I
Transcription By RNA Polymerase II
DNA Damage Response
Response To Oxidative Stress
JNK Cascade
Nervous System Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Response To Toxic Substance
Response To X-ray
Response To UV-B
Response To Gamma Radiation
Positive Regulation Of Gene Expression
Protein Ubiquitination
Neurogenesis
Neuron Differentiation
Neuron Projection Development
Regulation Of DNA-templated Transcription Elongation
Positive Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
Regulation Of Transcription Elongation By RNA Polymerase II
Multicellular Organism Growth
DNA Protection
Photoreceptor Cell Maintenance
Positive Regulation Of DNA Repair
Positive Regulation Of Transcription By RNA Polymerase I
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase III
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Protein Localization To Chromatin
Double-strand Break Repair Via Classical Nonhomologous End Joining
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Negative Regulation Of Transcription By RNA Polymerase II
Cytoplasmic Translation
Translation
Regulation Of Translation
Negative Regulation Of Apoptotic Process
Embryonic Brain Development
Pathways
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
B-WICH complex positively regulates rRNA expression
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
RNA Polymerase I Transcription Initiation
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Artenimol
Diseases
Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
Cockayne syndrome
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Pulse pressure x alcohol consumption interaction (2df test) (
29912962
)
Interacting Genes
117 interacting genes:
ACTR2
ACTR3
ARPC1A
ATP5F1C
ATP5PO
CAVIN1
CCT5
CCT6A
CHEK2
CLIC4
COPE
CORO1C
CSNK2A2
CSNK2B
CTSB
CUL5
DARS1
DCLRE1A
ECHS1
EIF3C
EIF3D
EIF3F
EIF3I
EIF3L
EIF4A3
ELOA
ERCC5
ERCC8
FBLN2
FNDC3B
FOSL1
FXR1
FYTTD1
GATAD2B
GRPEL1
GTF2E2
GTF2I
H2BC3
H3C1
H4C1
HDAC1
HDAC2
HNRNPUL2
HSPA5
HSPA9
HTATSF1
IARS2
IDH3G
IWS1
LEO1
MBD3
MORC3
MRPL11
MRPL13
MRPL20
MRPL21
MRPL3
MRPL38
MRPL4
MRPL47
MRPL50
MRPL58
MRPS18B
MRPS22
MRPS25
MRPS26
MTA1
MTA2
MTA3
NAP1L1
NONO
NPLOC4
PAF1
PARP1
PCNA
PFN2
PML
POLR2A
POLR2H
PPIA
PSMC5
RBBP7
RCC1
RHOG
RNF11
RPL10
RPL13
RPL30
RPL39
RPL5
RPS15
RPS15A
RPS24
RPS29
RPS6
SAE1
SDHA
SENP2
SF3B3
SLC39A7
SNRPD1
SUMO1
SUMO2
SUPT6H
TACO1
TP53
TPR
UBA2
UBC
UBE2I
UQCRC1
UQCRQ
USP7
XAB2
XPA
XRCC5
ZBTB38
15 interacting genes:
DUX4
ERCC6
FYN
HCK
LYN
MAPK6
OGT
PRKCA
PTEN
RAD21
SRC
SUMO2
TAB1
TBPL1
YES1
Entrez ID
2074
6134
HPRD ID
00596
02421
Ensembl ID
ENSG00000225830
ENSG00000147403
Uniprot IDs
P0DP91
Q03468
Q59FF6
P27635
X5D2T3
PDB IDs
4CVO
6A6I
7OO3
7OOB
7OOP
7OPC
7OPD
8B3D
8B3F
9BZ0
9ER2
9FD2
2PA2
5AJ0
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6W6L
7F5S
7XNX
7XNY
8A3D
8FLD
8FLE
8FLF
8G5Y
8G5Z
8G60
8G61
8G6J
8GLP
8K2C
8QFD
8XSY
8XSZ
8YOO
8YOP
9C3H
9GMO
Enriched GO Terms of Interacting Partners
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Translation
Ribosome
Macromolecule Metabolic Process
RNA Binding
Macromolecule Biosynthetic Process
Structural Constituent Of Ribosome
Ribonucleoprotein Complex
Mitochondrial Translation
Nucleoplasm
Protein Metabolic Process
NuRD Complex
Mitochondrial Large Ribosomal Subunit
Mitochondrial Inner Membrane
Regulation Of Cell Fate Specification
Regulation Of Cell Fate Commitment
Nucleus
Protein-RNA Complex Assembly
Cytosolic Ribosome
Ubiquitin Protein Ligase Binding
Nucleic Acid Metabolic Process
PML Body
Regulation Of Stem Cell Differentiation
Small Protein Activating Enzyme Binding
Cytoplasmic Translation
Formation Of Cytoplasmic Translation Initiation Complex
Chromosome, Telomeric Region
Eukaryotic Translation Initiation Factor 3 Complex
Nucleobase-containing Compound Metabolic Process
Eukaryotic 48S Preinitiation Complex
Protein Sumoylation
Mitochondrion
Eukaryotic 43S Preinitiation Complex
Cytoplasmic Translational Initiation
Chromatin Organization
Protein-containing Complex
Nucleosomal DNA Binding
Nucleolus
DNA Repair
Chromatin Remodeling
Mitochondrial Ribosome
Regulation Of Protein Metabolic Process
Transcription-coupled Nucleotide-excision Repair
Translational Initiation
Nucleotide-excision Repair
Protein-containing Complex Organization
DNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Double-strand Break Repair
Protein-containing Complex Assembly
Chromosome
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Fc-gamma Receptor Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Fc Receptor Signaling Pathway
Protein Modification Process
T Cell Costimulation
Protein Tyrosine Kinase Activity
Ephrin Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Protein Kinase Activity
Protein Phosphorylation
Innate Immune Response-activating Signaling Pathway
Negative Regulation Of Inflammatory Response
Immune Response-activating Signaling Pathway
Intracellular Signal Transduction
Kinase Activity
Stimulatory C-type Lectin Receptor Signaling Pathway
Phosphate-containing Compound Metabolic Process
Phosphorylation
Cellular Response To Lectin
Signaling Receptor Binding
Cellular Response To Platelet-derived Growth Factor Stimulus
Enzyme Binding
Activation Of Innate Immune Response
Actin Filament
Negative Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
Response To Platelet-derived Growth Factor
Activation Of Immune Response
Leukocyte Migration
Ephrin Receptor Binding
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Defense Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Defense Response
Protein Metabolic Process
Transferase Activity
Positive Regulation Of Innate Immune Response
Response To Peptide Hormone
Transmembrane Transporter Binding
Regulation Of Phosphorus Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Cell Cycle
Response To Reactive Oxygen Species
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