IFT140

Name	intraflagellar transport 140
Structure
Novel Interactors	7 novel interactors: DNAJA3 IL32 NHERF2 RAB11FIP3 TELO2 TRAP1 ZNF263
Interactors	5 interactors: CELSR3 CRK NEK2 PFDN1 RANBP2
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Centrosome Centriole Cytoskeleton Cilium Axoneme Intraciliary Transport Particle A Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Ciliary Tip Non-motile Cilium Cone Photoreceptor Outer Segment
	Molecular Function	Protein Binding
	Biological Process	Determination Of Left/right Symmetry Heart Development Regulation Of Smoothened Signaling Pathway Neural Tube Patterning Cell Projection Organization Embryonic Camera-type Eye Development Limb Morphogenesis Intraciliary Retrograde Transport Photoreceptor Cell Outer Segment Organization Intraciliary Transport Embryonic Digit Morphogenesis Embryonic Cranial Skeleton Morphogenesis Cilium Assembly Protein Localization To Cilium Regulation Of Cilium Assembly Non-motile Cilium Assembly Embryonic Brain Development
Pathways	Hedgehog 'off' state Intraflagellar transport
GWAS	Coronary artery disease ( 29212778 33020668 ) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383 )
Entrez ID	9742
HPRD ID	11093
Ensembl ID	ENSG00000187535
Uniprot IDs	Q96RY7
PDB IDs	8BBF 8BBG 8FGW 8FH3
GO Terms Enriched among Interactors ?	Protein Folding Negative Regulation Of Innate Immune Response Protein Localization To Membrane Unfolded Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity Negative Regulation Of Immune Response Localization Within Membrane Helper T Cell Diapedesis Cerebellar Neuron Development Protein Phosphorylated Amino Acid Binding Negative Regulation Of Defense Response Neuromuscular Junction Response To Cholecystokinin Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Negative Regulation Of Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Intercellular Bridge Cytoplasmic Periphery Of The Nuclear Pore Complex IkappaB Kinase Complex Binding Type II Interferon Receptor Binding Positive Regulation Of Type III Interferon Production Type 3 Metabotropic Glutamate Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Cleavage Furrow 'de Novo' Cotranslational Protein Folding TTT Hsp90 Cochaperone Complex Translational Attenuation