IFT140 and CELSR3

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		IFT140	CELSR3
Description		intraflagellar transport 140	cadherin EGF LAG seven-pass G-type receptor 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Centrosome Centriole Cytoskeleton Cilium Axoneme Intraciliary Transport Particle A Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Ciliary Tip Non-motile Cilium Cone Photoreceptor Outer Segment	Plasma Membrane Adherens Junction Membrane
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding Protein Binding
	Biological Process	Determination Of Left/right Symmetry Heart Development Regulation Of Smoothened Signaling Pathway Neural Tube Patterning Cell Projection Organization Embryonic Camera-type Eye Development Limb Morphogenesis Intraciliary Retrograde Transport Photoreceptor Cell Outer Segment Organization Intraciliary Transport Embryonic Digit Morphogenesis Embryonic Cranial Skeleton Morphogenesis Cilium Assembly Protein Localization To Cilium Regulation Of Cilium Assembly Non-motile Cilium Assembly Embryonic Brain Development	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Axonogenesis Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Cell-cell Adhesion Mediated By Cadherin Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Hedgehog 'off' state Intraflagellar transport
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778 33020668) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability (MTAG) ( 29186694) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mental health study participation (provided email address) ( 31263887) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		5 interacting genes: CELSR3 CRK NEK2 PFDN1 RANBP2	14 interacting genes: CLK1 CLUH DSCR9 DST IFT140 REST SCAPER SGSM2 SPTBN2 SPTBN4 SWAP70 TRIP12 TSPYL4 UACA
Entrez ID		9742	1951
HPRD ID		11093	09179
Ensembl ID		ENSG00000187535	ENSG00000008300
Uniprot IDs		Q96RY7	Q9NYQ7
PDB IDs		8BBF 8BBG 8FGW 8FH3
Enriched GO Terms of Interacting Partners?		Protein Folding Negative Regulation Of Innate Immune Response Protein Localization To Membrane Unfolded Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity Negative Regulation Of Immune Response Localization Within Membrane Helper T Cell Diapedesis Cerebellar Neuron Development Protein Phosphorylated Amino Acid Binding Negative Regulation Of Defense Response Neuromuscular Junction Response To Cholecystokinin Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Negative Regulation Of Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Intercellular Bridge Cytoplasmic Periphery Of The Nuclear Pore Complex IkappaB Kinase Complex Binding Type II Interferon Receptor Binding Positive Regulation Of Type III Interferon Production Type 3 Metabotropic Glutamate Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Cleavage Furrow 'de Novo' Cotranslational Protein Folding TTT Hsp90 Cochaperone Complex Translational Attenuation	Negative Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Depolymerization Spectrin Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein Depolymerization Regulation Of Protein-containing Complex Disassembly Actin Binding Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Actin Filament Capping Cell Cortex Cell Junction Organization Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Amniotic Stem Cell Differentiation Negative Regulation Of Actin Filament Polymerization Structural Constituent Of Synapse Postsynaptic Spectrin-associated Cytoskeleton Cytoskeleton Cortical Actin Cytoskeleton H Zone Negative Regulation Of Mesenchymal Stem Cell Differentiation Synapse Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Cerebellar Purkinje Cell Layer Morphogenesis Structural Constituent Of Postsynapse Heterochromatin Boundary Formation Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Chromatin Remodeling
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