IFT140 and PFDN1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		IFT140	PFDN1
Description		intraflagellar transport 140	prefoldin subunit 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Centrosome Centriole Cytoskeleton Cilium Axoneme Intraciliary Transport Particle A Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Ciliary Tip Non-motile Cilium Cone Photoreceptor Outer Segment	Cytoplasm Prefoldin Complex Protein-containing Complex
	Molecular Function	Protein Binding	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Determination Of Left/right Symmetry Heart Development Regulation Of Smoothened Signaling Pathway Neural Tube Patterning Cell Projection Organization Embryonic Camera-type Eye Development Limb Morphogenesis Intraciliary Retrograde Transport Photoreceptor Cell Outer Segment Organization Intraciliary Transport Embryonic Digit Morphogenesis Embryonic Cranial Skeleton Morphogenesis Cilium Assembly Protein Localization To Cilium Regulation Of Cilium Assembly Non-motile Cilium Assembly Embryonic Brain Development	Protein Folding Negative Regulation Of Amyloid Fibril Formation
Pathways		Hedgehog 'off' state Intraflagellar transport	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778 33020668) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)	Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)
Interacting Genes		5 interacting genes: CELSR3 CRK NEK2 PFDN1 RANBP2	55 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEBPA CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235
Entrez ID		9742	5201
HPRD ID		11093	05357
Ensembl ID		ENSG00000187535	ENSG00000113068
Uniprot IDs		Q96RY7	O60925
PDB IDs		8BBF 8BBG 8FGW 8FH3	6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Protein Folding Negative Regulation Of Innate Immune Response Protein Localization To Membrane Unfolded Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity Negative Regulation Of Immune Response Localization Within Membrane Helper T Cell Diapedesis Cerebellar Neuron Development Protein Phosphorylated Amino Acid Binding Negative Regulation Of Defense Response Neuromuscular Junction Response To Cholecystokinin Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Negative Regulation Of Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Intercellular Bridge Cytoplasmic Periphery Of The Nuclear Pore Complex IkappaB Kinase Complex Binding Type II Interferon Receptor Binding Positive Regulation Of Type III Interferon Production Type 3 Metabotropic Glutamate Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Cleavage Furrow 'de Novo' Cotranslational Protein Folding TTT Hsp90 Cochaperone Complex Translational Attenuation	Positive Regulation Of Microtubule Nucleation Structural Constituent Of Cytoskeleton Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Microtubule Nucleation Nuclear Matrix Positive Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Double-strand Break Repair Intracellular Protein Localization Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Glutamate Receptor Binding Regulation Of Cellular Component Organization
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