RHBDD2 and USP30

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RHBDD2	USP30
Description		rhomboid domain containing 2	ubiquitin specific peptidase 30
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Perinuclear Region Of Cytoplasm	Nucleus Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Cytosol Membrane
	Molecular Function	Serine-type Endopeptidase Activity Signal Recognition Particle Binding Protein Binding	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity
	Biological Process	Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway	Autophagy Of Mitochondrion Pexophagy Proteolysis Mitochondrial Fusion Protein Deubiquitination Regulation Of Protein Stability Protein K11-linked Deubiquitination Protein K6-linked Deubiquitination Negative Regulation Of Mitophagy
Pathways			Ub-specific processing proteases Pexophagy
Drugs
Diseases
GWAS		Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Sum eosinophil basophil counts ( 27863252)	Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494)
Interacting Genes		60 interacting genes: ABHD16A ACSF2 ADORA2A BCL2L1 BCL2L2 CCR9 CHRM4 CIAO2A CIDEB COL8A1 COMT DIABLO DRD2 DYNC1H1 ERBB2 FKBP8 FMO4 GAL3ST3 GCSH GDF5-AS1 H2BC3 H4C7 IFI27L1 IL32 LETMD1 LIG4 MAOB MICOS13 MIEF2 MLX MMRN2 MPC2 MRM1 MRPL35 MTERF3 MYG1 NAALAD2 NCBP2AS2 NEDD4 NFU1 NRM PBX3 PTAFR ROMO1 RSAD2 SCGB3A1 SDHD SLC25A2 SLC25A3 SLC71A3P SNPH SYT16 TEX44 THBD TIMM17B TPRG1 TSR1 TUFM USP30 YAP1	6 interacting genes: PAICS POLG PRKN RHBDD2 UBB UBC
Entrez ID		57414	84749
HPRD ID		11492	15633
Ensembl ID		ENSG00000005486	ENSG00000135093
Uniprot IDs		Q6NTF9	B3KUS5 Q70CQ3
PDB IDs			5OHK 5OHN 5OHP 8D0A 8D1T
Enriched GO Terms of Interacting Partners?		Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Synaptic Transmission, Dopaminergic Mitochondrial Envelope Mitochondrion Organization Apoptotic Signaling Pathway Response To Amphetamine Dopamine Metabolic Process Response To Alkaloid Regulation Of Catecholamine Secretion Protein Binding Response To Amine Membrane Epithelial Cell Proliferation Mitochondrial Membrane Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway Mitochondrial Matrix Catecholamine Catabolic Process Catecholamine Metabolic Process Dopamine Catabolic Process Protein Localization To Mitochondrion	Protein Tag Activity Mitochondrial Outer Membrane Proteolysis Involved In Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Protein Ubiquitination Negative Regulation Of Intralumenal Vesicle Formation Modification-dependent Protein Catabolic Process Regulation Of Mitochondrial Membrane Potential Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Membrane Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin ERAD Pathway Positive Regulation Of Protein Ubiquitination Mitochondrion Localization Proteolysis Macromolecule Catabolic Process Mitochondrion Regulation Of Signal Transduction By P53 Class Mediator DNA Replication Proofreading Mitochondrial Chromosome Gamma DNA Polymerase Complex Endocytic Vesicle Membrane Hypothalamus Gonadotrophin-releasing Hormone Neuron Development Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Phosphoribosylaminoimidazole Carboxylase Activity Protein Modification By Small Protein Conjugation Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Lyase Activity Lewy Body Regulation Of Spontaneous Synaptic Transmission Regulation Of Proteasomal Protein Catabolic Process Type 2 Mitophagy Post-translational Protein Modification Regulation Of Protein Ubiquitination
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?