RHBDD2 and MAOB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RHBDD2	MAOB
Description		rhomboid domain containing 2	monoamine oxidase B
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Perinuclear Region Of Cytoplasm	Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Membrane
	Molecular Function	Serine-type Endopeptidase Activity Signal Recognition Particle Binding Protein Binding	Protein Binding Primary Methylamine Oxidase Activity Electron Transfer Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding Monoamine Oxidase Activity
	Biological Process	Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway	Substantia Nigra Development Dopamine Catabolic Process Hydrogen Peroxide Biosynthetic Process
Pathways			Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
Drugs			Amphetamine Amphetamine Phentermine Procaine Tranylcypromine Phenelzine Zonisamide Selegiline Pioglitazone Procarbazine Moclobemide Moclobemide Isocarboxazid Ephedra sinica root Rasagiline MMDA 4-Methoxyamphetamine Metamfetamine Pargyline Isatin (R)-N-methyl-N-2-propynyl-1-indanamine Farnesol N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate Flavin adenine dinucleotide N-Propargyl-1(S)-Aminoindan Dodecyldimethylamine N-oxide 5-Hydroxy-N-Propargyl-1(R)-Aminoindan N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINE Nialamide Nomifensine Zimelidine Safinamide 7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE 7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE N-(2-AMINOETHYL)-P-CHLOROBENZAMIDE (1Z)-4-(4-FLUOROPHENYL)-2-METHYLIDENEBUTAN-1-IMINE 4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN (S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE] Viloxazine Flortaucipir F-18 Vafidemstat
Diseases
GWAS		Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		60 interacting genes: ABHD16A ACSF2 ADORA2A BCL2L1 BCL2L2 CCR9 CHRM4 CIAO2A CIDEB COL8A1 COMT DIABLO DRD2 DYNC1H1 ERBB2 FKBP8 FMO4 GAL3ST3 GCSH GDF5-AS1 H2BC3 H4C7 IFI27L1 IL32 LETMD1 LIG4 MAOB MICOS13 MIEF2 MLX MMRN2 MPC2 MRM1 MRPL35 MTERF3 MYG1 NAALAD2 NCBP2AS2 NEDD4 NFU1 NRM PBX3 PTAFR ROMO1 RSAD2 SCGB3A1 SDHD SLC25A2 SLC25A3 SLC71A3P SNPH SYT16 TEX44 THBD TIMM17B TPRG1 TSR1 TUFM USP30 YAP1	6 interacting genes: COX20 FGF14 NFYB RHBDD2 SRPK1 TRIM54
Entrez ID		57414	4129
HPRD ID		11492	02401
Ensembl ID		ENSG00000005486	ENSG00000069535
Uniprot IDs		Q6NTF9	B7Z242 P27338
PDB IDs			1GOS 1OJ9 1OJA 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66 2C67 2C70 2C72 2C73 2C75 2C76 2V5Z 2V60 2V61 2VRL 2VRM 2VZ2 2XCG 2XFN 2XFO 2XFP 2XFQ 2XFU 3PO7 3ZYX 4A79 4A7A 4CRT 5MRL 6FVZ 6FW0 6FWC 6RKB 6RKP 6RLE 6YT2 7B0V 7B0Z 7P4F 7P4H 7ZW3 9FJT
Enriched GO Terms of Interacting Partners?		Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Synaptic Transmission, Dopaminergic Mitochondrial Envelope Mitochondrion Organization Apoptotic Signaling Pathway Response To Amphetamine Dopamine Metabolic Process Response To Alkaloid Regulation Of Catecholamine Secretion Protein Binding Response To Amine Membrane Epithelial Cell Proliferation Mitochondrial Membrane Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway Mitochondrial Matrix Catecholamine Catabolic Process Catecholamine Metabolic Process Dopamine Catabolic Process Protein Localization To Mitochondrion
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