RHBDD2 and ROMO1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RHBDD2	ROMO1
Description		rhomboid domain containing 2	reactive oxygen species modulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Perinuclear Region Of Cytoplasm	Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Membrane
	Molecular Function	Serine-type Endopeptidase Activity Signal Recognition Particle Binding Protein Binding	Protein Binding Monoatomic Cation Transmembrane Transporter Activity
	Biological Process	Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway	Intracellular Protein Transport Protein Import Into Mitochondrial Matrix Killing Of Cells Of Another Organism Cellular Response To Reactive Oxygen Species Defense Response To Bacterium Protein Insertion Into Mitochondrial Inner Membrane Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Cytolysis By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Replicative Senescence Monoatomic Cation Transmembrane Transport Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Drugs
Diseases
GWAS		Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Sum eosinophil basophil counts ( 27863252)	Refractive error ( 32231278)
Interacting Genes		60 interacting genes: ABHD16A ACSF2 ADORA2A BCL2L1 BCL2L2 CCR9 CHRM4 CIAO2A CIDEB COL8A1 COMT DIABLO DRD2 DYNC1H1 ERBB2 FKBP8 FMO4 GAL3ST3 GCSH GDF5-AS1 H2BC3 H4C7 IFI27L1 IL32 LETMD1 LIG4 MAOB MICOS13 MIEF2 MLX MMRN2 MPC2 MRM1 MRPL35 MTERF3 MYG1 NAALAD2 NCBP2AS2 NEDD4 NFU1 NRM PBX3 PTAFR ROMO1 RSAD2 SCGB3A1 SDHD SLC25A2 SLC25A3 SLC71A3P SNPH SYT16 TEX44 THBD TIMM17B TPRG1 TSR1 TUFM USP30 YAP1	2 interacting genes: CIDEB RHBDD2
Entrez ID		57414	140823
HPRD ID		11492	12774
Ensembl ID		ENSG00000005486	ENSG00000125995
Uniprot IDs		Q6NTF9	P60602
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Synaptic Transmission, Dopaminergic Mitochondrial Envelope Mitochondrion Organization Apoptotic Signaling Pathway Response To Amphetamine Dopamine Metabolic Process Response To Alkaloid Regulation Of Catecholamine Secretion Protein Binding Response To Amine Membrane Epithelial Cell Proliferation Mitochondrial Membrane Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway Mitochondrial Matrix Catecholamine Catabolic Process Catecholamine Metabolic Process Dopamine Catabolic Process Protein Localization To Mitochondrion	Execution Phase Of Apoptosis COPI-coated Vesicle Phosphatidic Acid Binding COPII Vesicle Coat Lipid Transfer Activity Lipid Droplet Fusion Perinuclear Region Of Cytoplasm Protein-lipid Complex Assembly COPII-coated Vesicle Cargo Loading Plasma Lipoprotein Particle Assembly Very-low-density Lipoprotein Particle Assembly Signal Recognition Particle Binding Endoplasmic Reticulum Membrane Lipid Storage Intermembrane Lipid Transfer Vesicle Cargo Loading Regulation Of Triglyceride Metabolic Process Lipid Droplet Organization Golgi Apparatus Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Lipid Droplet Intracellular Signal Transduction ERAD Pathway Organelle Fusion
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