RHBDD2 and DRD2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		RHBDD2	DRD2
Description		rhomboid domain containing 2	dopamine receptor D2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Perinuclear Region Of Cytoplasm	Golgi Membrane Acrosomal Vesicle Golgi Apparatus Plasma Membrane Cilium Membrane Lateral Plasma Membrane Endocytic Vesicle Axon Dendrite Synaptic Vesicle Membrane Sperm Flagellum Presynaptic Membrane Dendritic Spine Perikaryon Axon Terminus Synapse Postsynaptic Membrane Ciliary Membrane G Protein-coupled Receptor Complex Non-motile Cilium Dopaminergic Synapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Serine-type Endopeptidase Activity Signal Recognition Particle Binding Protein Binding	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Heterotrimeric G-protein Binding Dopamine Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway	Temperature Homeostasis Response To Hypoxia Neuron Migration Synaptic Transmission, Dopaminergic Startle Response Response To Amphetamine Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Heart Rate Regulation Of Sodium Ion Transport G Protein-coupled Receptor Internalization Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Receptor Internalization Intracellular Calcium Ion Homeostasis Autophagy Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Neuroblast Proliferation Axonogenesis Synapse Assembly Sensory Perception Of Smell Long-term Memory Grooming Behavior Locomotory Behavior Adult Walking Behavior Feeding Behavior Intracellular Protein Localization Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Associative Learning Visual Learning Response To Xenobiotic Stimulus Response To Light Stimulus Response To Toxic Substance Response To Iron Ion Regulation Of Dopamine Secretion Response To Inactivity Wnt Signaling Pathway Cell Migration Striatum Development Orbitofrontal Cortex Development Cerebral Cortex GABAergic Interneuron Migration Adenohypophysis Development Negative Regulation Of Cell Migration Peristalsis Adult Behavior Forebrain Development Auditory Behavior Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Negative Regulation Of Dopamine Secretion Response To Histamine Response To Nicotine Negative Regulation Of Dephosphorylation Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Multicellular Organism Growth Response To Cocaine Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Dopamine Metabolic Process Drinking Behavior Regulation Of Potassium Ion Transport Response To Morphine Regulation Of MAPK Cascade Pigmentation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Ethanol Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Blood Pressure Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Acid Secretion Behavioral Response To Cocaine Behavioral Response To Ethanol Regulation Of Long-term Neuronal Synaptic Plasticity Response To Axon Injury Branching Morphogenesis Of A Nerve Arachidonate Secretion Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Secretion Positive Regulation Of Neurogenesis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Neurotransmitter Uptake Dopamine Uptake Involved In Synaptic Transmission Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Synapse Structural Plasticity Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Amine Transport Negative Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Positive Regulation Of Growth Hormone Secretion Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Ethanol Regulation Of Locomotion Involved In Locomotory Behavior Postsynaptic Modulation Of Chemical Synaptic Transmission Presynaptic Modulation Of Chemical Synaptic Transmission Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Negative Regulation Of Cellular Response To Hypoxia Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Secretion By Cell Hyaloid Vascular Plexus Regression Negative Regulation Of Neuron Migration
Pathways			Dopamine receptors
Drugs			Amphetamine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Thiethylperazine Sulpiride Loxapine Remoxipride Pramipexole Promazine Prochlorperazine Droperidol Imipramine Chlorpromazine Buspirone Haloperidol Triflupromazine Nortriptyline Amoxapine Lamotrigine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Trifluoperazine Perphenazine Flupentixol Amantadine Mesoridazine Maprotiline Dopamine Carphenazine Memantine Ergoloid mesylate Acetophenazine Promethazine Pimozide Desipramine Escitalopram Domperidone Pergolide Bromocriptine Ketamine Quetiapine Metoclopramide Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Alizapride Rolicyclidine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Tetrabenazine Brasofensine Bifeprunox Bicifadine Itopride Iloperidone Rotigotine BL-1020 Norclozapine Amitifadine Cariprazine Lumateperone YKP-1358 Sertindole Mianserin Asenapine Ocaperidone Amisulpride Sarizotan Sumanirole Nandrolone decanoate Lurasidone Perospirone Bromopride Quinagolide Brexpiprazole Etoperidone AS-8112 Blonanserin Melperone Zotepine Pipamperone Dihydro-alpha-ergocryptine Epicriptine Pardoprunox Tetrahydropalmatine Piribedil Raclopride JNJ-37822681 Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Sum eosinophil basophil counts ( 27863252)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032 30643258) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 33861876) Alcoholic chronic pancreatitis ( 28754779) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety ( 33859377) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33263727) Body mass index ( 26426971) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 33859377) General factor of neuroticism ( 30867560) Inferior temporal gyrus volume ( 31530798) Information processing speed ( 25869804) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Mood instability ( 31168069) Neuroticism ( 29255261 27089181) Problematic alcohol use ( 32451486) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Schizophrenia ( 30285260 29483656 28991256 25056061) Select biomarker traits ( 17903293) Sleep duration ( 27992416) Smoking cessation ( 33082346) Smoking status (current vs mixed) ( 33082346) Smoking status (current vs never) ( 33082346) Sociability score ( 34054130) Systolic blood pressure in sickle cell anemia ( 24058526) Triglycerides ( 30275531) Walking pace ( 33128006) Worry too long after an embarrassing experience ( 34054130)
Interacting Genes		60 interacting genes: ABHD16A ACSF2 ADORA2A BCL2L1 BCL2L2 CCR9 CHRM4 CIAO2A CIDEB COL8A1 COMT DIABLO DRD2 DYNC1H1 ERBB2 FKBP8 FMO4 GAL3ST3 GCSH GDF5-AS1 H2BC3 H4C7 IFI27L1 IL32 LETMD1 LIG4 MAOB MICOS13 MIEF2 MLX MMRN2 MPC2 MRM1 MRPL35 MTERF3 MYG1 NAALAD2 NCBP2AS2 NEDD4 NFU1 NRM PBX3 PTAFR ROMO1 RSAD2 SCGB3A1 SDHD SLC25A2 SLC25A3 SLC71A3P SNPH SYT16 TEX44 THBD TIMM17B TPRG1 TSR1 TUFM USP30 YAP1	86 interacting genes: ABCA2 ADGRB1 ADGRG1 ADORA2A APH1A ARL1 ARL6IP6 ATP6V0A2 ATP6V0C BCAP29 BCAP31 CADPS CADPS2 CALM1 CALM3 CCKBR CERS1 CERS2 CHPT1 CLDND1 CLIC6 CRELD1 EPB41 EPB41L1 FLNA GABBR1 GABBR2 GDPD2 GHITM GIPC1 GNAI2 GNAI3 GNAZ GNB5 GPR137 GPR37 GRIA2 GRINA HRH3 KBTBD6 KBTBD7 KCNJ6 KCNJ9 LPAR1 NCS1 NDUFV1 NEFM NSF OPRM1 PAQR6 PAWR PIGG PLLP PLPPR3 PPP1R9B RHBDD2 RTN1 RTN3 RTN4 SERINC3 SLC15A4 SLC22A17 SLC35B1 SLC4A3 SLC6A1 SLC6A3 SMIM7 SPP1 SSTR2 SSTR5 SYNGR2 TF TMEFF2 TMEM101 TMEM11 TMEM63A TRAM1 TRPC4 TRPC5 TSPAN3 TSPAN7 TTYH1 WFS1 WLS YIPF3 ZDHHC4
Entrez ID		57414	1813
HPRD ID		11492	00539
Ensembl ID		ENSG00000005486	ENSG00000149295
Uniprot IDs		Q6NTF9	P14416
PDB IDs			5AER 6CM4 6LUQ 6VMS 7DFP 7JVR 8IRS 8TZQ 8U02
Enriched GO Terms of Interacting Partners?		Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Synaptic Transmission, Dopaminergic Mitochondrial Envelope Mitochondrion Organization Apoptotic Signaling Pathway Response To Amphetamine Dopamine Metabolic Process Response To Alkaloid Regulation Of Catecholamine Secretion Protein Binding Response To Amine Membrane Epithelial Cell Proliferation Mitochondrial Membrane Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway Mitochondrial Matrix Catecholamine Catabolic Process Catecholamine Metabolic Process Dopamine Catabolic Process Protein Localization To Mitochondrion	Membrane Plasma Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Monoatomic Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Inorganic Ion Transmembrane Transport Synapse Dendrite Inorganic Cation Transmembrane Transport Regulation Of Transport Presynaptic Membrane Metal Ion Transport G Protein-coupled Receptor Activity Endoplasmic Reticulum Membrane Golgi Membrane Dendritic Shaft Endoplasmic Reticulum Tubular Network Formation Amino Acid Transport Neuronal Cell Body Negative Regulation Of Voltage-gated Calcium Channel Activity Endoplasmic Reticulum Tubular Network Membrane Organization Calcium Channel Complex Neuropeptide Binding Regulation Of Signaling Negative Regulation Of Adenylate Cyclase Activity Dendritic Spine Negative Regulation Of High Voltage-gated Calcium Channel Activity G Protein-coupled GABA Receptor Activity G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex Heterotrimeric G-protein Complex Secretion Regulation Of Cell Communication Golgi Apparatus Postsynaptic Membrane Positive Regulation Of Signaling Regulation Of Voltage-gated Calcium Channel Activity Membrane Organization Gamma-delta T Cell Receptor Complex GABA Receptor Complex Ligand-gated Monoatomic Cation Channel Activity Cellular Response To Morphine D2 Dopamine Receptor Binding Endoplasmic Reticulum Membrane Organization Regulation Of Secretion By Cell
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