RHBDD2 and TIMM17B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RHBDD2	TIMM17B
Description		rhomboid domain containing 2	translocase of inner mitochondrial membrane 17B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Perinuclear Region Of Cytoplasm	Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Membrane
	Molecular Function	Serine-type Endopeptidase Activity Signal Recognition Particle Binding Protein Binding	Protein Binding Protein Transmembrane Transporter Activity
	Biological Process	Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway	Protein Targeting To Mitochondrion Intracellular Protein Transport Protein Transport Protein Import Into Mitochondrial Matrix
Pathways			Mitochondrial protein import Mitochondrial protein import
Drugs
Diseases
GWAS		Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Sum eosinophil basophil counts ( 27863252)	Type 2 diabetes ( 30718926)
Interacting Genes		60 interacting genes: ABHD16A ACSF2 ADORA2A BCL2L1 BCL2L2 CCR9 CHRM4 CIAO2A CIDEB COL8A1 COMT DIABLO DRD2 DYNC1H1 ERBB2 FKBP8 FMO4 GAL3ST3 GCSH GDF5-AS1 H2BC3 H4C7 IFI27L1 IL32 LETMD1 LIG4 MAOB MICOS13 MIEF2 MLX MMRN2 MPC2 MRM1 MRPL35 MTERF3 MYG1 NAALAD2 NCBP2AS2 NEDD4 NFU1 NRM PBX3 PTAFR ROMO1 RSAD2 SCGB3A1 SDHD SLC25A2 SLC25A3 SLC71A3P SNPH SYT16 TEX44 THBD TIMM17B TPRG1 TSR1 TUFM USP30 YAP1	9 interacting genes: APP CIDEB CREB3 MPC2 RHBDD2 TEX44 TIMM23 TRIM55 TRIM63
Entrez ID		57414	10245
HPRD ID		11492	02218
Ensembl ID		ENSG00000005486	ENSG00000126768
Uniprot IDs		Q6NTF9	O60830
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Synaptic Transmission, Dopaminergic Mitochondrial Envelope Mitochondrion Organization Apoptotic Signaling Pathway Response To Amphetamine Dopamine Metabolic Process Response To Alkaloid Regulation Of Catecholamine Secretion Protein Binding Response To Amine Membrane Epithelial Cell Proliferation Mitochondrial Membrane Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway Mitochondrial Matrix Catecholamine Catabolic Process Catecholamine Metabolic Process Dopamine Catabolic Process Protein Localization To Mitochondrion	Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Intracellular Transport Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Response To Stress Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Monocyte Chemotaxis Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Deacetylase Activity Arginyl-tRNA--protein Transferase Activity Acetylcholine Receptor Activator Activity Response To Interleukin-1 Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Cellular Localization Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Localization In Cell Protein Arginylation Protein K63-linked Ubiquitination Pyruvate Import Into Mitochondria Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Mononuclear Cell Migration Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Chemotaxis Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Mitochondrial Inner Membrane Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Identical Protein Binding Intracellular Signal Transduction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Pyruvate Transmembrane Transporter Activity
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