SYT2 and WNK1

Number of citations of the paper that reports this interaction (PMID 15350218)
22

Data Source:
HPRD (in vivo)

		SYT2	WNK1
Gene Name		synaptotagmin II	WNK lysine deficient protein kinase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle	Cytoplasm
	Molecular Function	Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding	Protein Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Phosphatase Binding
	Biological Process	Transport Pathogenesis	Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Ion Transport Negative Regulation Of Phosphatase Activity Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Neuron Development Regulation Of Cellular Process
Pathways		Uptake and actions of bacterial toxins Toxicity of botulinum toxin type B (BoNT/B) Neurotoxicity of clostridium toxins	Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: KLHL3 NRXN1 STON2 SYNCRIP WNK1	37 interactors: ADRB2 AKT1 ARAF ATP8 ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 MAP2K1 MAP3K2 MAP3K3 NEDD4L PFKP PRKAR1A PRKAR1B PVR RANBP9 RBX1 SLC9A1 SUMO1 SYT2 TNRC6A TSC22D1 UBC UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX
Entrez ID		127833	65125
HPRD ID		02520	05570
Ensembl ID		ENSG00000143858	ENSG00000060237
Uniprot IDs		Q8N9I0	A5D8Z4 F5GWT4 H6WZW3 Q9H4A3
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Complex Assembly Involved In Synapse Maturation Gamma-aminobutyric Acid Receptor Clustering Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Gephyrin Clustering Synaptic Vesicle Clustering Distal Tubule Morphogenesis Developmental Process Vesicle Localization Renal Sodium Ion Absorption Neuronal Signal Transduction Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport N-methyl-D-aspartate Receptor Clustering Vocal Learning CRD-mediated MRNA Stabilization Negative Regulation Of Filopodium Assembly Postsynaptic Membrane Assembly Synapse Maturation Regulation Of Grooming Behavior Presynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Cell Differentiation Presynaptic Membrane Organization Auditory Behavior Positive Regulation Of Systemic Arterial Blood Pressure Renal Absorption Cerebellar Granule Cell Differentiation Distal Tubule Development Organelle Localization Vocalization Behavior Prepulse Inhibition Neuron Cell-cell Adhesion Positive Regulation Of Synapse Maturation Mechanosensory Behavior Cerebellar Granular Layer Morphogenesis Response To Auditory Stimulus Regulation Of Synapse Maturation Protein Localization To Synapse System Development Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Cerebellar Granular Layer Development Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Membrane Biogenesis Positive Regulation Of Protein Localization To Plasma Membrane MRNA Stabilization	Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Sodium Ion Transport Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Activation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Intracellular Transport Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Sodium Ion Transport Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Growth Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Protein Kinase Activity Response To Fibroblast Growth Factor Cellular Response To Peptide Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Kinase Activity Establishment Of Localization In Cell Signal Transduction Cell Communication Cellular Localization Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Intracellular Signal Transduction Positive Regulation Of Mitochondrion Organization Cellular Response To Organic Substance Regulation Of Cellular Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Phosphorylation Cellular Response To Mechanical Stimulus Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		anion apical begin bring buffered ca2 chloromethylfluorescein cmfda conferring cytosolic diacetate disrupted epithelia hepatocytes inositol insp3r insp3rs mis peri polarized synaptotagmins syt1 syts tether tethered tethering tethers trisphosphate waves	alanine associate cation ccc cccs chloride compromise cotransporters disruption hence knock lens lenses maintain opacification osr1 proline rat regionally spak ste20 subcellular subcellularly susceptibility transcript transcriptase transparency wet
Tagcloud (Difference) ?		anion apical begin bring buffered ca2 chloromethylfluorescein cmfda conferring cytosolic diacetate disrupted epithelia hepatocytes inositol insp3r insp3rs mis peri polarized synaptotagmins syt1 syts tether tethered tethering tethers trisphosphate waves	alanine associate cation ccc cccs chloride compromise cotransporters disruption hence knock lens lenses maintain opacification osr1 proline rat regionally spak ste20 subcellular subcellularly susceptibility transcript transcriptase transparency wet
Tagcloud (Intersection) ?