SYT2 and KLHL3

Number of citations of the paper that reports this interaction (PubMedID 10734137)
0

Data Source:
HPRD (in vitro)

		SYT2	KLHL3
Description		synaptotagmin 2	kelch like family member 3
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Chromaffin Granule Membrane Synapse Exocytic Vesicle	Cytoplasm Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	SNARE Binding Protein Binding Calcium-dependent Phospholipid Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Metal Ion Binding Calcium Ion Sensor Activity	Actin Binding Structural Molecule Activity Protein Binding Cullin Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Calcium-dependent Activation Of Synaptic Vesicle Fusion Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Gene Expression Macroautophagy Protein Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Monoatomic Ion Homeostasis Potassium Ion Homeostasis Renal Absorption Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis
Pathways		Toxicity of botulinum toxin type B (botB) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Botulinum toxin type B
Diseases
GWAS		Celiac disease ( 23936387) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)	Bronchopulmonary dysplasia ( 23897914) Heart failure ( 31919418) Hemoglobin ( 32888494) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)
Interacting Genes		29 interacting genes: AQP10 BNIP2 CCDC167 CLDN4 CMTM3 FA2H FUNDC2 ITGAM KLHL3 LAT MALL MIP NAPB NRXN1 ORMDL3 PLPP4 PMP22 SLC30A8 SLC35A1 SLC35A4 STON2 SYNCRIP TF THSD7B TMEM107 TMEM229B TSPO2 VAMP4 WNK1	16 interacting genes: AKT1 CFAP206 GNAI1 GNAO1 KLHL12 MORF4L2 OPRD1 PPP3CA PRKACA RBX1 SYNCRIP SYT2 TNPO2 UBE2D3 WNK3 WNK4
Entrez ID		127833	26249
HPRD ID		02520	09011
Ensembl ID		ENSG00000143858	ENSG00000146021
Uniprot IDs		Q8N9I0	Q9UH77
PDB IDs		6G5G	4CH9 4HXI 5NKP
Enriched GO Terms of Interacting Partners?		Membrane Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Transmembrane Transport Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Homeostatic Process Endocytic Vesicle Water Channel Activity Chemical Homeostasis	Renal Sodium Ion Transport Renal Sodium Ion Absorption Renal Absorption Renal System Process Regulation Of Metal Ion Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Secretion Negative Regulation Of Protein Localization Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Postsynaptic Modulation Of Chemical Synaptic Transmission Proteasomal Protein Catabolic Process Regulation Of Transport Positive Regulation Of Steroid Biosynthetic Process Adenylate Cyclase Regulator Activity Positive Regulation Of Steroid Metabolic Process Negative Regulation Of Pancreatic Juice Secretion Ubiquitin-dependent Protein Catabolic Process Regulation Of System Process Modification-dependent Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization Regulation Of Cholesterol Metabolic Process Protein Catabolic Process Negative Regulation Of Secretion Protein Monoubiquitination Sodium Ion Transport Proteolysis Involved In Protein Catabolic Process TORC1 Signaling Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Negative Regulation Of TORC1 Signaling Regulation Of Sodium Ion Transport Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Biological Quality Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Calcium Ion Transport Regulation Of Steroid Biosynthetic Process Protein Modification Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway TOR Signaling Negative Regulation Of TOR Signaling Nuclear Transport Nucleocytoplasmic Transport Vascular Endothelial Cell Response To Fluid Shear Stress Nucleotide Binding
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