SYT2 and CLDN4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYT2	CLDN4
Description		synaptotagmin 2	claudin 4
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Chromaffin Granule Membrane Synapse Exocytic Vesicle	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basal Plasma Membrane Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Chloride Channel Complex Tight Junction Anchoring Junction
	Molecular Function	SNARE Binding Protein Binding Calcium-dependent Phospholipid Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Metal Ion Binding Calcium Ion Sensor Activity	Transmembrane Signaling Receptor Activity Structural Molecule Activity Chloride Channel Activity Protein Binding Identical Protein Binding
	Biological Process	Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Calcium-dependent Activation Of Synaptic Vesicle Fusion Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis	Monoatomic Ion Transport Chloride Transport Cell Adhesion Female Pregnancy Circadian Rhythm Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Response To Progesterone Monoatomic Ion Transmembrane Transport Establishment Of Skin Barrier Renal Absorption Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Paracellular Transport Chloride Transmembrane Transport
Pathways		Toxicity of botulinum toxin type B (botB) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Tight junction interactions
Drugs		Botulinum toxin type B
Diseases
GWAS		Celiac disease ( 23936387) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)
Interacting Genes		29 interacting genes: AQP10 BNIP2 CCDC167 CLDN4 CMTM3 FA2H FUNDC2 ITGAM KLHL3 LAT MALL MIP NAPB NRXN1 ORMDL3 PLPP4 PMP22 SLC30A8 SLC35A1 SLC35A4 STON2 SYNCRIP TF THSD7B TMEM107 TMEM229B TSPO2 VAMP4 WNK1	19 interacting genes: AQP6 ARL13B CLEC14A EPHA2 FAM209A FFAR2 GJA8 GOLM1 HSD17B13 ICAM3 SHBG SLC71A2 SYT2 TJP1 TMEM237 TMEM52B TRIM59 TSPO2 WNK4
Entrez ID		127833	1364
HPRD ID		02520	04218
Ensembl ID		ENSG00000143858	ENSG00000189143
Uniprot IDs		Q8N9I0	O14493 Q75L80
PDB IDs		6G5G	5B2G 7KP4 7TDM 7TDN 8U4V 8U5B 9CMH 9CMI
Enriched GO Terms of Interacting Partners?		Membrane Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Transmembrane Transport Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Homeostatic Process Endocytic Vesicle Water Channel Activity Chemical Homeostasis	Membrane
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