CNTN1 and NOTCH2

Number of citations of the paper that reports this interaction (PMID 14567914)
71

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CNTN1	NOTCH2
Gene Name		contactin 1	notch 2
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Membrane Receptor Complex
	Molecular Function	Glycoprotein Binding Carbohydrate Binding	Receptor Activity Calcium Ion Binding Protein Binding Ligand-activated RNA Polymerase II Transcription Factor Binding Transcription Factor Activity
	Biological Process	Cell Adhesion Notch Signaling Pathway Axon Guidance Positive Regulation Of Gene Expression Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Cerebellum Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Cell Fate Determination Morphogenesis Of An Epithelial Sheet Inflammatory Response To Antigenic Stimulus Pulmonary Valve Morphogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process Humoral Immune Response Cell Cycle Arrest Notch Signaling Pathway Notch Receptor Processing Multicellular Organismal Development Determination Of Left/right Symmetry Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Gene Expression Cell Growth Stem Cell Maintenance Hemopoiesis Embryonic Limb Morphogenesis Positive Regulation Of BMP Signaling Pathway Intracellular Receptor Signaling Pathway Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Notch Signaling Involved In Heart Development Interleukin-4 Secretion
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH L1CAM interactions NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Neurofascin interactions Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer	Notch-HLH transcription pathway Signaling by NOTCH2 Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)	Type 2 diabetes ( 18372903)
Protein-Protein Interactions		12 interactors: CNTN2 FYN L1CAM MAPK6 NOTCH1 NOTCH2 PPP1CA PRNP PTPRB SCNN1B TNC TNR	18 interactors: CNTN1 CRKL DLL1 DTX1 EGFL7 GSK3B JAG1 JAG2 LFNG MAML1 MAML2 MAML3 MFNG MYOC PSEN1 PSEN2 RBPJ SMAD1
Entrez ID		1272	4853
HPRD ID		07189	02606
Ensembl ID		ENSG00000018236	ENSG00000134250
Uniprot IDs		Q12860	Q04721 Q6IQ50 Q9UFD5
PDB IDs		2EE2 3S97	2OO4
Enriched GO Terms of Interacting Partners?		Axon Development Anatomical Structure Morphogenesis Response To External Stimulus Neuron Projection Development Axonogenesis Neuron Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Adhesion Neuron Projection Morphogenesis Neuron Differentiation Cell Projection Organization Cell Development Cell Morphogenesis Involved In Differentiation Axon Guidance System Development Cell Projection Morphogenesis Cell Part Morphogenesis Negative Regulation Of Cell Adhesion Nervous System Development Generation Of Neurons Response To Stimulus Neurogenesis Multicellular Organismal Development Cell Morphogenesis Anatomical Structure Development Response To Growth Factor Chemotaxis Learning Or Memory Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Cognition Locomotion Interleukin-4 Production Positive Regulation Of Signal Transduction Developmental Process Organ Development Regulation Of Signaling Regulation Of Cell-cell Adhesion Cell Migration Response To Ethanol Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Learning Cell Motility Forebrain Development Cell Differentiation Single-organism Behavior Notch Receptor Processing Regulation Of Cell Morphogenesis	Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Notch Receptor Processing Regulation Of Notch Signaling Pathway Multicellular Organismal Development Pattern Specification Process Cell Fate Commitment Generation Of Neurons System Development Signal Transduction Positive Regulation Of Notch Signaling Pathway Neurogenesis Positive Regulation Of Signal Transduction Developmental Process Organ Development Signaling Anatomical Structure Morphogenesis Cell Communication Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Development Regulation Of Cell Differentiation Cell Differentiation Heart Development Regulation Of Protein Binding Regulation Of Signal Transduction Regulation Of Neuron Differentiation Regulation Of Cell Development Cardiovascular System Development Tissue Development Nervous System Development Cellular Response To Stimulus Cell Development Regulation Of Signaling Negative Regulation Of Neuron Differentiation Somitogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Immune System Development Regulation Of Neurogenesis Epithelium Development Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Somite Development Neuron Differentiation Anterior/posterior Pattern Specification Regulation Of Binding Segmentation Auditory Receptor Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Neurogenesis
Tagcloud ?		axin2 axonogenesis coding dendritogenesis interplay inverse maintaining maturing microrna micrornas mrnas ncam1 negr1 neurite neurotrophin nrxn1 ontology orchestrated prkcb pruning represented respective rnas sh2b3 synaptogenesis temporally tightly transcriptome verification	activates associates atypical cbf1 coactivator cofactor correlate defines deltex drosophila e47 effort gal4 hairless homolog hybrid immunoglobulin interacting jkappa jun physically ras rbp reversed rpb sapk unaffected
Tagcloud (Difference) ?		axin2 axonogenesis coding dendritogenesis interplay inverse maintaining maturing microrna micrornas mrnas ncam1 negr1 neurite neurotrophin nrxn1 ontology orchestrated prkcb pruning represented respective rnas sh2b3 synaptogenesis temporally tightly transcriptome verification	activates associates atypical cbf1 coactivator cofactor correlate defines deltex drosophila e47 effort gal4 hairless homolog hybrid immunoglobulin interacting jkappa jun physically ras rbp reversed rpb sapk unaffected
Tagcloud (Intersection) ?