CNTN1 and SCNN1B

Number of citations of the paper that reports this interaction (PubMedID 11567041)
46

Data Source:
HPRD (in vivo)

		CNTN1	SCNN1B
Description		contactin 1	sodium channel epithelial 1 subunit beta
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GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Presynaptic Membrane Synapse Postsynaptic Membrane Extracellular Exosome Side Of Membrane Glutamatergic Synapse	Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Sodium Channel Complex Extracellular Exosome
	Molecular Function	Protein Binding Carbohydrate Binding Cell-cell Adhesion Mediator Activity	Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process	Cell Adhesion Notch Signaling Pathway Axon Guidance Brain Development Locomotory Behavior Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Cerebellum Development Neuron Projection Development Central Nervous System Myelin Formation Myelination Cell-cell Adhesion	Leukocyte Activation Involved In Inflammatory Response Neutrophil Activation Involved In Immune Response Renal System Process Monoatomic Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of Blood Pressure Response To Xenobiotic Stimulus Gene Expression Artery Smooth Muscle Contraction Response To Food Aldosterone Metabolic Process Erythrocyte Homeostasis Monoatomic Ion Transmembrane Transport Multicellular Organism Growth Sodium Ion Transmembrane Transport Epithelial Fluid Transport Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Sensory Perception Of Sour Taste Potassium Ion Homeostasis Sodium Ion Homeostasis Mucus Secretion Neutrophil-mediated Killing Of Bacterium Cellular Response To Acidic PH Sodium Ion Import Across Plasma Membrane Cellular Response To Aldosterone Cellular Response To Vasopressin
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus L1CAM interactions Neurofascin interactions	Stimuli-sensing channels Sensory perception of salty taste
Drugs			Triamterene Amiloride
Diseases			Liddle syndrome Bronchiectasis with or without elevated sweat chloride Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Blood protein levels ( 30072576) Body mass index ( 26426971) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Metabolite levels (X-11787) ( 23934736) Motion sickness ( 25628336) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pneumoconiosis in silica exposure ( 24986923) Protein quantitative trait loci ( 18464913)	Kidney stones ( 31729369)
Interacting Genes		17 interacting genes: CNTN2 FYN GPR37 L1CAM MAPK6 MAVS NOTCH1 NOTCH2 PPP1CA PRNP PTPRB SCN3A SCNN1B TMEM132D TNC TNR USP25	14 interacting genes: ANK3 CNTN1 COMMD10 EPN1 HECW1 ITCH NEDD4 NEDD4L NFASC SCNN1A SCNN1D SCNN1G STX1A WWP2
Entrez ID		1272	6338
HPRD ID		07189	02861
Ensembl ID		ENSG00000018236	ENSG00000168447
Uniprot IDs		Q12860	B2R812 H3BQ95 P51168
PDB IDs		2EE2 3S97	6BQN 6WTH 9BLR 9BTG 9BTU
Enriched GO Terms of Interacting Partners?		Neuron Projection Development Neuron Projection Guidance Plasma Membrane Bounded Cell Projection Organization Axon Guidance Cell Projection Organization Cell Surface Cellular Response To Tumor Cell Type 5 Metabotropic Glutamate Receptor Binding Tenascin Complex Negative Regulation Of Dendritic Spine Maintenance Positive Regulation Of Cell Communication Positive Regulation Of Signaling Atrioventricular Node Development Developmental Growth Receptor Complex Dendritic Spine Maintenance Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Dendritic Spine Maintenance Regulation Of Calcium Ion Import Across Plasma Membrane Left/right Axis Specification Synapse Organization Learning Or Memory Schaffer Collateral - CA1 Synapse Pulmonary Valve Morphogenesis Nervous System Process Positive Regulation Of Ras Protein Signal Transduction Cell Migration Glutamatergic Synapse Morphogenesis Of An Epithelial Sheet Regulation Of Cellular Component Organization Cognition Response To Stress Prostate Gland Epithelium Morphogenesis Negative Regulation Of Cell Adhesion Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Morphogenesis Of An Epithelium Renal Tubule Development Positive Regulation Of Protein Targeting To Membrane Cellular Response To Hormone Stimulus Developmental Growth Involved In Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Motility Regulation Of Axonogenesis Regulation Of Cell Projection Organization Response To Oxidative Stress Regulation Of Astrocyte Differentiation Regulation Of Protein Targeting To Membrane Dendritic Spine Organization	Negative Regulation Of Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Sensory Perception Of Salty Taste Negative Regulation Of Potassium Ion Transport Import Into Cell Negative Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Aldosterone Sodium Channel Complex Sensory Perception Of Sour Taste Cellular Response To Vasopressin Potassium Channel Inhibitor Activity Transmembrane Transporter Binding Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Sodium Ion Transport Negative Regulation Of Cation Transmembrane Transport Response To Aldosterone Negative Regulation Of Monoatomic Ion Transmembrane Transport Cellular Response To Acidic PH Regulation Of Potassium Ion Transport Intracellular Sodium Ion Homeostasis Inorganic Cation Import Across Plasma Membrane Negative Regulation Of Monoatomic Ion Transport Response To Acidic PH Ubiquitin-protein Transferase Activity Cellular Response To PH Negative Regulation Of Transmembrane Transport Sensory Perception Of Taste Sodium Channel Activity Sodium Ion Homeostasis Neuromuscular Junction Development Response To Mineralocorticoid Sodium Ion Transmembrane Transport Response To PH Import Across Plasma Membrane Regulation Of Metal Ion Transport Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Monoubiquitination Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Sodium Channel Inhibitor Activity Regulation Of Dendrite Morphogenesis Endocytosis Cellular Response To Corticosteroid Stimulus Receptor Internalization Protein K63-linked Ubiquitination
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