CNTN1 and SCN3A

Number of citations of the paper that reports this interaction (PubMedID 15317864)
59

Data Source:
BioGRID (pull down, affinity chromatography technology)

		CNTN1	SCN3A
Description		contactin 1	sodium voltage-gated channel alpha subunit 3
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Presynaptic Membrane Synapse Postsynaptic Membrane Extracellular Exosome Side Of Membrane Glutamatergic Synapse	Voltage-gated Sodium Channel Complex Plasma Membrane Basal Plasma Membrane Membrane Sarcoplasm Monoatomic Ion Channel Complex
	Molecular Function	Protein Binding Carbohydrate Binding Cell-cell Adhesion Mediator Activity	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity
	Biological Process	Cell Adhesion Notch Signaling Pathway Axon Guidance Brain Development Locomotory Behavior Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Cerebellum Development Neuron Projection Development Central Nervous System Myelin Formation Myelination Cell-cell Adhesion	Action Potential Monoatomic Ion Transport Sodium Ion Transport Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Behavioral Response To Pain Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Action Potential
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus L1CAM interactions Neurofascin interactions	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs			Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Zonisamide Promethazine Chloroprocaine Tetrodotoxin Brivaracetam Lacosamide Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS		Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Blood protein levels ( 30072576) Body mass index ( 26426971) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Metabolite levels (X-11787) ( 23934736) Motion sickness ( 25628336) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pneumoconiosis in silica exposure ( 24986923) Protein quantitative trait loci ( 18464913)	Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Epilepsy ( 30531953) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Metabolite levels ( 23823483) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Parkinson's disease ( 28892059) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		17 interacting genes: CNTN2 FYN GPR37 L1CAM MAPK6 MAVS NOTCH1 NOTCH2 PPP1CA PRNP PTPRB SCN3A SCNN1B TMEM132D TNC TNR USP25	5 interacting genes: CNTN1 LRP1 LRP2 LRP8 PRKCG
Entrez ID		1272	6328
HPRD ID		07189	01671
Ensembl ID		ENSG00000018236	ENSG00000153253
Uniprot IDs		Q12860	A0A590UJH3 A0A994J5P2 Q9C007 Q9NY46
PDB IDs		2EE2 3S97	7W77 7W7F
Enriched GO Terms of Interacting Partners?		Neuron Projection Development Neuron Projection Guidance Plasma Membrane Bounded Cell Projection Organization Axon Guidance Cell Projection Organization Cell Surface Cellular Response To Tumor Cell Type 5 Metabotropic Glutamate Receptor Binding Tenascin Complex Negative Regulation Of Dendritic Spine Maintenance Positive Regulation Of Cell Communication Positive Regulation Of Signaling Atrioventricular Node Development Developmental Growth Receptor Complex Dendritic Spine Maintenance Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Dendritic Spine Maintenance Regulation Of Calcium Ion Import Across Plasma Membrane Left/right Axis Specification Synapse Organization Learning Or Memory Schaffer Collateral - CA1 Synapse Pulmonary Valve Morphogenesis Nervous System Process Positive Regulation Of Ras Protein Signal Transduction Cell Migration Glutamatergic Synapse Morphogenesis Of An Epithelial Sheet Regulation Of Cellular Component Organization Cognition Response To Stress Prostate Gland Epithelium Morphogenesis Negative Regulation Of Cell Adhesion Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Morphogenesis Of An Epithelium Renal Tubule Development Positive Regulation Of Protein Targeting To Membrane Cellular Response To Hormone Stimulus Developmental Growth Involved In Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Motility Regulation Of Axonogenesis Regulation Of Cell Projection Organization Response To Oxidative Stress Regulation Of Astrocyte Differentiation Regulation Of Protein Targeting To Membrane Dendritic Spine Organization	Low-density Lipoprotein Particle Receptor Activity Cargo Receptor Activity Positive Regulation Of Lysosomal Protein Catabolic Process Retinoid Metabolic Process Diterpenoid Metabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Terpenoid Metabolic Process Isoprenoid Metabolic Process Regulation Of Lysosomal Protein Catabolic Process Apolipoprotein Binding Transcytosis Receptor Complex Amyloid-beta Clearance Artery Morphogenesis Regulation Of Protein Catabolic Process Axon Positive Regulation Of Transcytosis Endocytosis Transport Across Blood-brain Barrier Clathrin-coated Pit Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Ammon Gyrus Development Amyloid-beta Binding Dendrite Blood Vessel Morphogenesis Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis System Process Folate Import Across Plasma Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Reelin Receptor Activity Calcium Ion Binding Import Into Cell Lipoprotein Particle Receptor Binding Folate Transmembrane Transport Sensory Perception Of Sound Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Mismatch Repair GET Complex Sensory Perception Of Mechanical Stimulus Positive Regulation Of Neuron Projection Development Astrocyte Activation Involved In Immune Response Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Mismatch Repair Very-low-density Lipoprotein Particle Receptor Activity Receptor-mediated Endocytosis Response To Psychosocial Stress Anatomical Structure Formation Involved In Morphogenesis
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