CNTN1 and PTPRB

Number of citations of the paper that reports this interaction (PubMedID 9049255)
66

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		CNTN1	PTPRB
Description		contactin 1	protein tyrosine phosphatase receptor type B
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Presynaptic Membrane Synapse Postsynaptic Membrane Extracellular Exosome Side Of Membrane Glutamatergic Synapse	Plasma Membrane Membrane Specific Granule Membrane Receptor Complex Tertiary Granule Membrane
	Molecular Function	Protein Binding Carbohydrate Binding Cell-cell Adhesion Mediator Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Cadherin Binding
	Biological Process	Cell Adhesion Notch Signaling Pathway Axon Guidance Brain Development Locomotory Behavior Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Cerebellum Development Neuron Projection Development Central Nervous System Myelin Formation Myelination Cell-cell Adhesion	Angiogenesis Osteoblast Differentiation Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Glial Cell Migration Dephosphorylation Developmental Process Negative Regulation Of Osteoblast Differentiation
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus L1CAM interactions Neurofascin interactions	Neutrophil degranulation
Drugs			{4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID (4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID {4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID (4-ETHYLPHENYL)SULFAMIC ACID Razuprotafib
Diseases
GWAS		Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Blood protein levels ( 30072576) Body mass index ( 26426971) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Metabolite levels (X-11787) ( 23934736) Motion sickness ( 25628336) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pneumoconiosis in silica exposure ( 24986923) Protein quantitative trait loci ( 18464913)	Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		17 interacting genes: CNTN2 FYN GPR37 L1CAM MAPK6 MAVS NOTCH1 NOTCH2 PPP1CA PRNP PTPRB SCN3A SCNN1B TMEM132D TNC TNR USP25	11 interacting genes: CDH5 CNTN1 CNTNAP1 EGFR F11R GHR MAGI3 MET NRCAM TEK TNC
Entrez ID		1272	5787
HPRD ID		07189	01474
Ensembl ID		ENSG00000018236	ENSG00000127329
Uniprot IDs		Q12860	F8VU56 P23467 Q86VA4
PDB IDs		2EE2 3S97	2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X 8JBN 8JBY
Enriched GO Terms of Interacting Partners?		Neuron Projection Development Neuron Projection Guidance Plasma Membrane Bounded Cell Projection Organization Axon Guidance Cell Projection Organization Cell Surface Cellular Response To Tumor Cell Type 5 Metabotropic Glutamate Receptor Binding Tenascin Complex Negative Regulation Of Dendritic Spine Maintenance Positive Regulation Of Cell Communication Positive Regulation Of Signaling Atrioventricular Node Development Developmental Growth Receptor Complex Dendritic Spine Maintenance Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Dendritic Spine Maintenance Regulation Of Calcium Ion Import Across Plasma Membrane Left/right Axis Specification Synapse Organization Learning Or Memory Schaffer Collateral - CA1 Synapse Pulmonary Valve Morphogenesis Nervous System Process Positive Regulation Of Ras Protein Signal Transduction Cell Migration Glutamatergic Synapse Morphogenesis Of An Epithelial Sheet Regulation Of Cellular Component Organization Cognition Response To Stress Prostate Gland Epithelium Morphogenesis Negative Regulation Of Cell Adhesion Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Morphogenesis Of An Epithelium Renal Tubule Development Positive Regulation Of Protein Targeting To Membrane Cellular Response To Hormone Stimulus Developmental Growth Involved In Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Motility Regulation Of Axonogenesis Regulation Of Cell Projection Organization Response To Oxidative Stress Regulation Of Astrocyte Differentiation Regulation Of Protein Targeting To Membrane Dendritic Spine Organization	Cell Adhesion Protein Phosphatase Binding Regulation Of Cellular Component Organization Cell-cell Junction Anchoring Junction Cell Junction Cell-cell Adhesion Bicellular Tight Junction Cell-cell Adhesion Mediator Activity Regulation Of Endothelial Cell Differentiation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Cell Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Mechanical Stimulus Receptor Complex Cell Junction Organization Basal Plasma Membrane Developmental Process Animal Organ Development Membrane Anatomical Structure Morphogenesis Synapse Organization Cell Junction Assembly Glutamatergic Synapse Action Potential Propagation Neuronal Action Potential Propagation Regulation Of Rho Protein Signal Transduction Endothelial Cell Morphogenesis Regulation Of Developmental Process Cell Surface Cadherin Binding Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activator Activity Response To Estradiol Morphogenesis Of An Epithelium Plasma Membrane Regulation Of Establishment Of Endothelial Barrier Cell-cell Junction Assembly Protein Localization To Cell-cell Junction Positive Regulation Of Homotypic Cell-cell Adhesion Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Developmental Process Tissue Morphogenesis Regulation Of Establishment Or Maintenance Of Cell Polarity Anatomical Structure Formation Involved In Morphogenesis
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