CNTN1 and MAVS

Number of citations of the paper that reports this interaction (PubMedID 35171955)
70

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CNTN1	MAVS
Description		contactin 1	mitochondrial antiviral signaling protein
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Presynaptic Membrane Synapse Postsynaptic Membrane Extracellular Exosome Side Of Membrane Glutamatergic Synapse	Ubiquitin Ligase Complex Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Carbohydrate Binding Cell-cell Adhesion Mediator Activity	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Identical Protein Binding CARD Domain Binding Molecular Adaptor Activity Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity
	Biological Process	Cell Adhesion Notch Signaling Pathway Axon Guidance Brain Development Locomotory Behavior Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Cerebellum Development Neuron Projection Development Central Nervous System Myelin Formation Myelination Cell-cell Adhesion	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Signal Transduction MRNA Transcription Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction NLRP3 Inflammasome Complex Assembly Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein Localization To Mitochondrion Cellular Response To Exogenous DsRNA Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of IP-10 Production Antiviral Innate Immune Response Regulation Of Peroxisome Organization Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus L1CAM interactions Neurofascin interactions	DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses PKR-mediated signaling
Drugs
Diseases
GWAS		Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Blood protein levels ( 30072576) Body mass index ( 26426971) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Metabolite levels (X-11787) ( 23934736) Motion sickness ( 25628336) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pneumoconiosis in silica exposure ( 24986923) Protein quantitative trait loci ( 18464913)	Platelet distribution width ( 32888494)
Interacting Genes		17 interacting genes: CNTN2 FYN GPR37 L1CAM MAPK6 MAVS NOTCH1 NOTCH2 PPP1CA PRNP PTPRB SCN3A SCNN1B TMEM132D TNC TNR USP25	32 interacting genes: ABL1 CCDC50 CNTN1 DDX3X EIF2AK2 IKBKB IRF3 IRF5 IRF7 KCNIP3 MAP1LC3A MAP3K7 OAS3 OTUD4 RIGI RIPK2 RNF115 RNF125 RNF135 RNF34 SMURF2 STAT1 TBK1 TICAM1 TNKS TNKS2 TRAF3 TRAF6 TRIM31 UBC UBE4A USP25
Entrez ID		1272	57506
HPRD ID		07189	13847
Ensembl ID		ENSG00000018236	ENSG00000088888
Uniprot IDs		Q12860	Q7Z434
PDB IDs		2EE2 3S97	2MS7 2MS8 2VGQ 3J6C 3J6J 3RC5 4P4H 4Z8M 5JEK 7DNI 8WKW
Enriched GO Terms of Interacting Partners?		Neuron Projection Development Neuron Projection Guidance Plasma Membrane Bounded Cell Projection Organization Axon Guidance Cell Projection Organization Cell Surface Cellular Response To Tumor Cell Type 5 Metabotropic Glutamate Receptor Binding Tenascin Complex Negative Regulation Of Dendritic Spine Maintenance Positive Regulation Of Cell Communication Positive Regulation Of Signaling Atrioventricular Node Development Developmental Growth Receptor Complex Dendritic Spine Maintenance Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Dendritic Spine Maintenance Regulation Of Calcium Ion Import Across Plasma Membrane Left/right Axis Specification Synapse Organization Learning Or Memory Schaffer Collateral - CA1 Synapse Pulmonary Valve Morphogenesis Nervous System Process Positive Regulation Of Ras Protein Signal Transduction Cell Migration Glutamatergic Synapse Morphogenesis Of An Epithelial Sheet Regulation Of Cellular Component Organization Cognition Response To Stress Prostate Gland Epithelium Morphogenesis Negative Regulation Of Cell Adhesion Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Morphogenesis Of An Epithelium Renal Tubule Development Positive Regulation Of Protein Targeting To Membrane Cellular Response To Hormone Stimulus Developmental Growth Involved In Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Motility Regulation Of Axonogenesis Regulation Of Cell Projection Organization Response To Oxidative Stress Regulation Of Astrocyte Differentiation Regulation Of Protein Targeting To Membrane Dendritic Spine Organization	Positive Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Regulation Of Type I Interferon Production Innate Immune Response-activating Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Immune Response-activating Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Interferon-beta Production Positive Regulation Of Interferon-beta Production Immune Response-regulating Signaling Pathway Activation Of Immune Response Intracellular Receptor Signaling Pathway Response To Virus Regulation Of Defense Response Positive Regulation Of Defense Response Defense Response To Virus Positive Regulation Of Interferon-alpha Production Antiviral Innate Immune Response Positive Regulation Of Cytokine Production Regulation Of Immune Response Positive Regulation Of Immune Response Regulation Of Cytokine Production Protein Polyubiquitination Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Defense Response To Symbiont MyD88-independent Toll-like Receptor Signaling Pathway Protein Ubiquitination Defense Response To Other Organism Response To Other Organism Response To External Biotic Stimulus Regulation Of Immune System Process Immune Response Protein Modification By Small Protein Conjugation Immune System Process Positive Regulation Of Immune System Process Defense Response Protein Modification Process Cytokine-mediated Signaling Pathway Post-translational Protein Modification Positive Regulation Of Gene Expression Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cytosol
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