MISP and DPPA4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MISP	DPPA4
Description		mitotic spindle positioning	developmental pluripotency associated 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Cell Cortex Cortical Actin Cytoskeleton Spindle Pole Centrosome Anchoring Junction Mitotic Spindle Astral Microtubule End	Nucleus Nucleoplasm
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Chromatin Binding Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Cell Migration Cell Division Organelle Localization Establishment Of Centrosome Localization Mitotic Spindle Assembly Regulation Of Protein Localization To Cell Cortex	System Development Lung-associated Mesenchyme Development
Pathways			POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Zygotic genome activation (ZGA)
Drugs
Diseases
GWAS			Cardiac hypertrophy ( 21348951) Corneal astigmatism ( 23761726) Metabolite levels ( 23823483)
Interacting Genes		51 interacting genes: ACTMAP BLZF1 CCDC33 CDK1 CDPF1 CEP76 CRBN DPH2 DPPA4 EFHC2 ENKD1 FHL2 FHL5 GOLGA2 GPRASP3 HNRNPK HSF2BP HSPB2 HSPB2-C11orf52 HSPB8 IKZF3 IRAK1BP1 KRTAP12-3 LMO1 LMO2 MAP1LC3C MORN3 MORN5 OIP5 PAX6 PFDN5 PIH1D1 PIH1D2 PLK1 PNMA2 PPP1R16B PRR5L PTK2 RIBC1 RINT1 RUSC1 SNW1 SOCS7 SPATC1L SPATS1 TERF1 TRAF2 TRIB3 TRIP6 VBP1 ZNF620	37 interacting genes: BTBD2 CIRSR CRK DPPA2 EAF1 EIF4A2 EMD FOXR1 GMPPB GRAP GRB2 GTPBP3 HTT INO80B KAT14 LDOC1 MAGOH MAP1LC3A MAP1LC3B MAPK6 MISP NEDD9 OSTF1 PLEKHF2 PTPRO QARS1 RPGRIP1 RPS6KB1 SH3GL1 SH3GL2 SH3GL3 SNX18 SNX33 SPANXN2 TLK1 TNIP1 VIM
Entrez ID		126353	55211
HPRD ID		12695	16836
Ensembl ID		ENSG00000099812	ENSG00000121570
Uniprot IDs		Q8IVT2	Q7L190
PDB IDs
Enriched GO Terms of Interacting Partners?		TORC1 Complex Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Protein Binding R2TP Complex Mitotic G2 DNA Damage Checkpoint Signaling Golgi Disassembly Establishment Of Mitotic Spindle Orientation Prefoldin Complex Centrosome Cycle Ventricular Cardiac Muscle Cell Development Protein Kinase Binding Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Ubiquitin Protein Ligase Binding Box C/D SnoRNP Assembly Mitotic Nuclear Membrane Disassembly Golgi Organization Mitotic G2/M Transition Checkpoint Cytoplasm Nucleus Establishment Of Spindle Localization	Phosphotyrosine Residue Binding Cytoplasm Protein Binding Cellular Response To Muramyl Dipeptide Cellular Response To Nitrogen Starvation Cleavage Furrow Formation Import Into Cell Endocytosis Central Nervous System Development Phosphatidylethanolamine Binding Plasma Membrane Tubulation Organelle Organization Spindle Pole Centrosome
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