MISP and SOCS7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MISP	SOCS7
Description		mitotic spindle positioning	suppressor of cytokine signaling 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Cell Cortex Cortical Actin Cytoskeleton Spindle Pole Centrosome Anchoring Junction Mitotic Spindle Astral Microtubule End	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Protein Binding SH3 Domain Binding Signaling Adaptor Activity Phosphorylation-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Cell Migration Cell Division Organelle Localization Establishment Of Centrosome Localization Mitotic Spindle Assembly Regulation Of Protein Localization To Cell Cortex	Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Layer Formation In Cerebral Cortex Intracellular Signal Transduction Reelin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Migration
Pathways
Drugs
Diseases
GWAS			Ovarian cancer ( 23535730)
Interacting Genes		51 interacting genes: ACTMAP BLZF1 CCDC33 CDK1 CDPF1 CEP76 CRBN DPH2 DPPA4 EFHC2 ENKD1 FHL2 FHL5 GOLGA2 GPRASP3 HNRNPK HSF2BP HSPB2 HSPB2-C11orf52 HSPB8 IKZF3 IRAK1BP1 KRTAP12-3 LMO1 LMO2 MAP1LC3C MORN3 MORN5 OIP5 PAX6 PFDN5 PIH1D1 PIH1D2 PLK1 PNMA2 PPP1R16B PRR5L PTK2 RIBC1 RINT1 RUSC1 SNW1 SOCS7 SPATC1L SPATS1 TERF1 TRAF2 TRIB3 TRIP6 VBP1 ZNF620	25 interacting genes: CYSRT1 DAB1 EGFR EXOSC8 GAS2L2 GRB2 HSPB8 IRS2 IRS4 LENG8 MDFI MISP NCK1 NSMF OSTF1 PIK3R1 PIK3R2 PLCG1 SH3RF1 SORBS2 SORBS3 TNS2 TUBA1A TUBB4B YES1
Entrez ID		126353	30837
HPRD ID		12695	12299
Ensembl ID		ENSG00000099812	ENSG00000274211
Uniprot IDs		Q8IVT2	A0A5F9YLF9 O14512
PDB IDs
Enriched GO Terms of Interacting Partners?		TORC1 Complex Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Protein Binding R2TP Complex Mitotic G2 DNA Damage Checkpoint Signaling Golgi Disassembly Establishment Of Mitotic Spindle Orientation Prefoldin Complex Centrosome Cycle Ventricular Cardiac Muscle Cell Development Protein Kinase Binding Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Ubiquitin Protein Ligase Binding Box C/D SnoRNP Assembly Mitotic Nuclear Membrane Disassembly Golgi Organization Mitotic G2/M Transition Checkpoint Cytoplasm Nucleus Establishment Of Spindle Localization	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Insulin Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphatase Binding Phosphotyrosine Residue Binding Focal Adhesion Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Phosphatidylinositol 3-kinase Binding Cytoskeletal Anchor Activity Insulin Receptor Binding Cell Surface Receptor Signaling Pathway Cytoplasm Structural Constituent Of Cytoskeleton Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Supramolecular Fiber Organization Intracellular Signaling Cassette Natural Killer Cell Mediated Cytotoxicity Regulation Of MAPK Cascade 1-phosphatidylinositol-3-kinase Regulator Activity Natural Killer Cell Mediated Immunity Regulation Of Actin Filament Organization Phosphatidylinositol 3-kinase Activator Activity Regulation Of Protein Localization To Cell Periphery Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Insulin Receptor Substrate Binding Leukocyte Mediated Cytotoxicity Regulation Of D-glucose Transmembrane Transport ERBB Signaling Pathway Regulation Of Actin Filament-based Process Signal Transduction Signaling Adaptor Activity Anchoring Junction Actin Filament Intracellular Glucose Homeostasis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Stress Fiber Assembly Regulation Of Cell Communication Regulation Of Signaling Cytoskeleton Organization Cellular Response To Insulin Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Motility
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