MISP and DPH2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MISP	DPH2
Description		mitotic spindle positioning	diphthamide biosynthesis 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Cell Cortex Cortical Actin Cytoskeleton Spindle Pole Centrosome Anchoring Junction Mitotic Spindle Astral Microtubule End	Cytosol Protein-containing Complex 2-(3-amino-3-carboxypropyl)histidine Synthase Complex
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding 2-(3-amino-3-carboxypropyl)histidine Synthase Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Cell Migration Cell Division Organelle Localization Establishment Of Centrosome Localization Mitotic Spindle Assembly Regulation Of Protein Localization To Cell Cortex	Protein Histidyl Modification To Diphthamide
Pathways			Synthesis of diphthamide-EEF2
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		51 interacting genes: ACTMAP BLZF1 CCDC33 CDK1 CDPF1 CEP76 CRBN DPH2 DPPA4 EFHC2 ENKD1 FHL2 FHL5 GOLGA2 GPRASP3 HNRNPK HSF2BP HSPB2 HSPB2-C11orf52 HSPB8 IKZF3 IRAK1BP1 KRTAP12-3 LMO1 LMO2 MAP1LC3C MORN3 MORN5 OIP5 PAX6 PFDN5 PIH1D1 PIH1D2 PLK1 PNMA2 PPP1R16B PRR5L PTK2 RIBC1 RINT1 RUSC1 SNW1 SOCS7 SPATC1L SPATS1 TERF1 TRAF2 TRIB3 TRIP6 VBP1 ZNF620	7 interacting genes: CRYGA FARS2 IL17A MAGOH MISP NEK6 TNK2
Entrez ID		126353	1802
HPRD ID		12695	16023
Ensembl ID		ENSG00000099812	ENSG00000132768
Uniprot IDs		Q8IVT2	B3KRB8 Q9BQC3
PDB IDs
Enriched GO Terms of Interacting Partners?		TORC1 Complex Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Protein Binding R2TP Complex Mitotic G2 DNA Damage Checkpoint Signaling Golgi Disassembly Establishment Of Mitotic Spindle Orientation Prefoldin Complex Centrosome Cycle Ventricular Cardiac Muscle Cell Development Protein Kinase Binding Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Ubiquitin Protein Ligase Binding Box C/D SnoRNP Assembly Mitotic Nuclear Membrane Disassembly Golgi Organization Mitotic G2/M Transition Checkpoint Cytoplasm Nucleus Establishment Of Spindle Localization
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