MISP and IRAK1BP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MISP	IRAK1BP1
Description		mitotic spindle positioning	interleukin 1 receptor associated kinase 1 binding protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Cell Cortex Cortical Actin Cytoskeleton Spindle Pole Centrosome Anchoring Junction Mitotic Spindle Astral Microtubule End	Nucleus Cytoplasm
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Protein Binding Signaling Adaptor Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Cell Migration Cell Division Organelle Localization Establishment Of Centrosome Localization Mitotic Spindle Assembly Regulation Of Protein Localization To Cell Cortex	Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction
Pathways
Drugs
Diseases
GWAS			Blood pressure measurement (high sodium and potassium intervention) ( 24165912) Blood pressure measurement (high sodium intervention) ( 24165912) Blood pressure measurement (low sodium intervention) ( 24165912) Cadmium levels ( 26025379) Daytime nap ( 33568662) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Late-onset Alzheimer's disease ( 27770636) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Macular thickness ( 30535121) Sjögren's syndrome ( 24097067)
Interacting Genes		51 interacting genes: ACTMAP BLZF1 CCDC33 CDK1 CDPF1 CEP76 CRBN DPH2 DPPA4 EFHC2 ENKD1 FHL2 FHL5 GOLGA2 GPRASP3 HNRNPK HSF2BP HSPB2 HSPB2-C11orf52 HSPB8 IKZF3 IRAK1BP1 KRTAP12-3 LMO1 LMO2 MAP1LC3C MORN3 MORN5 OIP5 PAX6 PFDN5 PIH1D1 PIH1D2 PLK1 PNMA2 PPP1R16B PRR5L PTK2 RIBC1 RINT1 RUSC1 SNW1 SOCS7 SPATC1L SPATS1 TERF1 TRAF2 TRIB3 TRIP6 VBP1 ZNF620	11 interacting genes: IRAK1 MISP PHF1 PRKAB2 RELA RIPPLY1 SCNM1 TFCP2 UFL1 USP20 ZNF410
Entrez ID		126353	134728
HPRD ID		12695	17157
Ensembl ID		ENSG00000099812	ENSG00000146243
Uniprot IDs		Q8IVT2	Q5VVH5
PDB IDs
Enriched GO Terms of Interacting Partners?		TORC1 Complex Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Protein Binding R2TP Complex Mitotic G2 DNA Damage Checkpoint Signaling Golgi Disassembly Establishment Of Mitotic Spindle Orientation Prefoldin Complex Centrosome Cycle Ventricular Cardiac Muscle Cell Development Protein Kinase Binding Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Ubiquitin Protein Ligase Binding Box C/D SnoRNP Assembly Mitotic Nuclear Membrane Disassembly Golgi Organization Mitotic G2/M Transition Checkpoint Cytoplasm Nucleus Establishment Of Spindle Localization	Canonical NF-kappaB Signal Transduction Antiviral Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Protein Kinase Binding Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of DNA-binding Transcription Factor Activity Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Innate Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Defense Response To Virus UFM1 Ligase Activity Positive Regulation Of Gliogenesis Positive Regulation Of Cell-cell Adhesion Response To Interleukin-1 Defense Response To Other Organism Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Defense Response To Symbiont NF-kappaB P50/p65 Complex UFM1 Transferase Activity Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Leukocyte Cell-cell Adhesion Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Metabolic Process Site Of Double-strand Break Regulation Of Gliogenesis Positive Regulation Of Schwann Cell Differentiation Response To Virus Negative Regulation Of Post-translational Protein Modification Response To Cobalamin Positive Regulation Of Reticulophagy Mitotic Spindle Astral Microtubule End Positive Regulation Of Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Response To Amino Acid Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Schwann Cell Differentiation NF-kappaB Complex Prolactin Signaling Pathway Regulation Of Reticulophagy Postsynapse To Nucleus Signaling Pathway Protein K69-linked Ufmylation Somite Specification
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