RAVER1 and ACTN1

Number of citations of the paper that reports this interaction (PMID 11724819)
35

Data Source:
HPRD (in vivo)

		RAVER1	ACTN1
Gene Name		ribonucleoprotein, PTB-binding 1	actinin, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Stress Fiber Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Fascia Adherens Focal Adhesion Z Disc Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding Poly(A) RNA Binding	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Ion Channel Binding Actin Filament Binding
	Biological Process		Platelet Degranulation Blood Coagulation Platelet Activation Extracellular Matrix Organization Cell Junction Assembly Regulation Of Apoptotic Process Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Crosslink Formation Regulation Of Nucleic Acid-templated Transcription
Pathways			Cell junction organization Syndecan interactions Response to elevated platelet cytosolic Ca2+ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Nephrin interactions Platelet degranulation Non-integrin membrane-ECM interactions Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs
Diseases
GWAS			Prostate cancer ( 23535732) Smoking behavior ( 19247474)
Protein-Protein Interactions		4 interactors: ACTN1 ACTN2 PTBP1 VCL	70 interactors: ACTN3 ADORA2A APC ATXN2 ATXN7 CACNA1A CAMK2A CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 EPM2AIP1 ERBB2IP FBP1 FXN GFI1B GIPC1 GIT2 GRIA4 GRIN2A GTF2H1 ITGB1 KAT2B KCTD6 KPNA2 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SLC2A4 SORBS2 SPERT SRC SSX2IP TES TTN VCL XRCC4 ZYX
Entrez ID		125950	87
HPRD ID		11484	00020
Ensembl ID		ENSG00000161847	ENSG00000072110
Uniprot IDs		E9PAU2 Q8IY67	P12814
PDB IDs		3H2U 3H2V 3SMZ 3VF0	2EYI 2EYN
Enriched GO Terms of Interacting Partners?		Adherens Junction Assembly Platelet Degranulation Adherens Junction Organization Cell-matrix Adhesion Platelet Activation Cell Junction Assembly Cell-cell Junction Organization Cell-substrate Adhesion Focal Adhesion Assembly Exocytosis Blood Coagulation Hemostasis Cell-substrate Junction Assembly Secretion By Cell Apical Junction Assembly Regulation Of Body Fluid Levels Wound Healing Secretion Cell Activation Response To Wounding Cell-cell Junction Assembly Cell Adhesion Muscle Contraction Negative Regulation Of Cellular Component Movement Protein Localization To Tight Junction Muscle System Process Vesicle-mediated Transport Cell Projection Assembly Microspike Assembly Negative Regulation Of Protein Localization To Cell Surface Protein Localization To Cell Junction Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Cellular Component Assembly Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Establishment Of Localization In Cell Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Actin Crosslink Formation Negative Regulation Of MRNA Splicing, Via Spliceosome Protein Localization To Cell Surface Regulation Of Protein Localization To Cell Surface Negative Regulation Of RNA Splicing Negative Regulation Of Potassium Ion Transport Cellular Localization Actin Filament-based Process Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Potassium Ion Transport Regulation Of Cellular Component Movement Muscle Filament Sliding	Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Organelle Organization Cell Development Regulation Of Protein Kinase Activity Actin Filament-based Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Cell-substrate Adhesion Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorus Metabolic Process Cell Differentiation Generation Of Neurons Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Stress Actomyosin Structure Organization Neuron Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Central Nervous System Development Positive Regulation Of Transferase Activity Regulation Of Signaling Response To Stimulus Response To Wounding Regulation Of Phosphorylation Cell-cell Junction Organization Regulation Of Cell Projection Organization Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Single Organismal Cell-cell Adhesion Adherens Junction Organization Neuron Projection Development Neuron Differentiation Anatomical Structure Development Blood Coagulation Cell Surface Receptor Signaling Pathway Cell Projection Organization Hemostasis Cell-matrix Adhesion Apical Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Neuron Projection Development
Tagcloud ?			b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc
Tagcloud (Difference) ?			b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc
Tagcloud (Intersection) ?