KRT40 and DDX6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KRT40	DDX6
Description		keratin 40	DEAD-box helicase 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Intermediate Filament Keratin Filament	Heterochromatin P-body Outer Dense Fiber Nucleus Cytoplasm Cytosol Plasma Membrane Adherens Junction Cytoplasmic Stress Granule Membrane RISC Complex Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Concave Side Of Sperm Head Sperm Annulus
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Domain Specific Binding Cadherin Binding
	Biological Process	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Intermediate Filament Organization	Spermatogenesis Negative Regulation Of Translation Viral RNA Genome Packaging Stem Cell Population Maintenance Neuron Differentiation P-body Assembly Stress Granule Assembly MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Neuron Differentiation Spermatid Differentiation
Pathways		Keratinization Formation of the cornified envelope	mRNA decay by 5' to 3' exoribonuclease
Drugs			D-tartaric acid
Diseases
GWAS		Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 34103634 30929738 31619474 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune traits (pleiotropy) ( 30572963) Blood protein levels ( 30072576) Celiac disease ( 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Diffuse cutaneous systemic sclerosis ( 24387989) Height ( 25429064) Hip minimal joint space width ( 27701424) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Systemic lupus erythematosus ( 19838195 28714469) Systemic sclerosis ( 31672989 24387989) Vitiligo ( 22951725)
Interacting Genes		385 interacting genes: ACSF3 ADAMTS1 ADAMTSL3 AEN AGXT AIRIM AKAP17A ALDH3B1 ANKRD36BP1 AP1M1 AQP1 AQP5 ARID5A ARMC7 ARSI ASMTL ATOSA ATPAF2 AVPI1 AXIN1 BAHD1 BARD1 BEX2 BMS1P1 BRME1 BYSL C10orf62 C11orf87 C19orf73 C1orf216 C22orf46P C2orf68 C8orf48 CA6 CARD9 CATIP CATSPERT CBX8 CCDC112 CCDC116 CCDC120 CCDC146 CCDC185 CCDC198 CCDC26 CCDC93 CCER1 CCNG1 CD33 CDC20B CDK18 CDK5R1 CELA2B CEP57 CEP57L1 CFAP206 CHCHD2 CHCHD3 CHIC2 CLEC18A CNNM3 CNTF COL8A1 COMT COX5A CREB5 CRY2 CTSZ CWF19L2 CYCS CYTH4 DAAM2 DCDC2B DCX DDX6 DHX57 DLGAP2 DMRT3 DOCK2 DOCK8 DTNB EIF4E2 ELOA ENKD1 EXOC3-AS1 FADS2 FAM107A FAM124B FAM27E3 FAM74A4 FAM90A1 FARS2 FASLG FBF1 FBXL18 FBXO34 FBXW5 FEZF1 FKBP1B FNDC11 FOXB1 FRG1 GAD1 GADD45GIP1 GARIN6 GATA2 GATAD2A GEM GFOD1 GGN GLIDR GNAI2 GNE GNG5 GOLGA6L2 GPATCH2L GTF3C5 GUCD1 HAPLN2 HAUS1 HBA2 HBZ HCK HDAC4 HGS HNRNPLL HOXA1 HOXB9 HOXC8 HSD3B7 HSF4 HSPA12B HSPD1 ING5 INO80B INPP5D IQUB ISCU ITGB4 ITGB5 JOSD1 KANK2 KAT5 KCTD9 KDM1A KIFC3 KLHL38 KPNA2 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT78 KRT79 KRT8 KRT81 KRT82 KRT83 KRT85 KRT86 LAGE3 LCE3E LENG1 LHX4 LIMS2 LIN37 LINC00636 LINC01588 LMF2 LMO1 LMO2 LMO4 LNX1 LRCH4 MAB21L2 MAGOHB MAPKBP1 MARK4 MED8 METTL17 MFAP1 MID2 MOB3C MOBP MOS MRPL11 MRRF MSRB3 MTA1 MXI1 MYPOP NAB2 NAPRT NEK6 NFKBID NINJ1 NOL4L-DT NPBWR2 NPPB NR1D2 NXF1 ODAD4 OIP5 OPCML OTUB2 PDLIM5 PEX39 PGLS PHF1 PHF21A PHLDA1 PIGS PIMREG PIN1 PKD2 POLDIP3 POLL POM121L8P POP5 PPP1R18 PRAM1 PRKAA1 PRKAB2 PRPF18 PRPF31 PSMA1 PSMB1 PSMC5 PTGER3 PTPMT1 PXMP2 QPRT RAB3IL1 RAB3IP RAC1 RASSF5 RBM41 RCOR3 RECK RGS8 RNF213 RNF6 RPL11 RSPH14 RTP5 RWDD2B RXRB SCAND1 SCNM1 SCOC SEMA4C SETD5 SH2D4A SHC3 SHFL SIRPA SLC23A1 SLC25A10 SLC35D4 SLIRP SLU7 SMARCE1 SMCO4 SNAI1 SNHG11 SNRPB SNW1 SPATA24 SPATA31J1 SPATC1L SPEF1 SPG7 SPMIP2 SRSF2 SSX2 SSX2IP SUOX SYT6 TACO1 TAPBPL TBC1D16 TBC1D21 TBC1D22B TCEA2 TCEANC TCHP TEAD4 THAP7 TIE1 TLE5 TMEM231 TMSB4X TNIP3 TNNT1 TRIM42 TROAP TRPV6 TSC22D4 TSGA10IP TSHZ3 TTC23 TTC9C TTLL10 TXLNA TXN2 TXNDC5 TYK2 TYRO3 UACA UBASH3A UCMA USHBP1 USP2 USP21 UTP14C UTP23 UXT VEZF1 WDR25 WT1 WT1-AS ZBTB16 ZBTB24 ZBTB38 ZBTB42 ZC2HC1C ZFHX3 ZFP1 ZFP2 ZFP69B ZFYVE21 ZFYVE26 ZGPAT ZMAT2 ZNF101 ZNF124 ZNF138 ZNF165 ZNF17 ZNF20 ZNF202 ZNF230 ZNF250 ZNF26 ZNF266 ZNF286A ZNF317 ZNF319 ZNF329 ZNF337 ZNF408 ZNF410 ZNF417 ZNF438 ZNF439 ZNF446 ZNF488 ZNF490 ZNF564 ZNF569 ZNF575 ZNF580 ZNF581 ZNF587 ZNF625 ZNF655 ZNF688 ZNF697 ZNF702P ZNF76 ZNF792 ZNF844 ZNRF2P1 ZSCAN21	75 interacting genes: BEGAIN BEND7 BIRC7 CALCOCO2 CCDC136 CCDC14 CEBPA CEP70 CEP76 CNKSR3 CNOT1 DDX17 DES DISC1 DNAAF11 EDC3 EFHC2 ENTR1 FCHO1 GOLGA2 GPRASP3 HOOK2 IK IKZF1 INKA1 JAKMIP1 JUP KLC4 KRT34 KRT40 KRTAP10-3 KRTAP10-8 LZTS1 MAGED1 MESD MTUS2 NAB2 NONO PAK5 PDLIM7 PICK1 PNMA5 POU6F2 PRDM16 PRPH RAPGEF3 RBM11 RBM14 REL RO60 RUNDC3A SCYL1 SHMT1 SLAIN1 SORBS3 SPATA6 SRPK2 STAT1 TCF12 TCF4 TLE5 TP53BP2 TRAF2 TRIM27 TRIM37 TRIM54 U2AF2 USH1G VPS52 ZBTB10 ZBTB14 ZBTB43 ZBTB8A ZC2HC1C ZNF24
Entrez ID		125115	1656
HPRD ID		08304	02638
Ensembl ID		ENSG00000204889	ENSG00000110367
Uniprot IDs		G3V1C2 Q6A162	B2R858 P26196
PDB IDs			1VEC 2WAX 2WAY 4CRW 4CT4 4CT5 5ANR 6F9S 6S8S
Enriched GO Terms of Interacting Partners?		Protein Binding Structural Constituent Of Skin Epidermis Keratin Filament Keratinization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Zinc Ion Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Supramolecular Fiber Organization RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleus Metal Ion Binding DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Speck Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Carbon Dioxide Transport	Cytoskeleton Identical Protein Binding Protein Binding Intermediate Filament Cytoplasm Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Microtubule Nuclear Speck Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Centriole Replication Transcription Coactivator Activity Intermediate Filament Organization Regulation Of MRNA Processing Regulation Of RNA Metabolic Process Cytosol Negative Regulation Of Centriole Replication Aggresome Tumor Necrosis Factor Receptor Binding Negative Regulation Of Metabolic Process Regulation Of Cytoskeleton Organization Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Regulation Of Organelle Organization Regulation Of MRNA Metabolic Process Centrosome Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament
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