KRT40 and POLL

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KRT40	POLL
Description		keratin 40	DNA polymerase lambda
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Intermediate Filament Keratin Filament	Nucleus Nucleoplasm Chromosome Site Of Double-strand Break
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity Lyase Activity DNA Polymerase Activity Metal Ion Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Intermediate Filament Organization	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Somatic Hypermutation Of Immunoglobulin Genes DNA Biosynthetic Process
Pathways		Keratinization Formation of the cornified envelope	Nonhomologous End-Joining (NHEJ)
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223)
Interacting Genes		385 interacting genes: ACSF3 ADAMTS1 ADAMTSL3 AEN AGXT AIRIM AKAP17A ALDH3B1 ANKRD36BP1 AP1M1 AQP1 AQP5 ARID5A ARMC7 ARSI ASMTL ATOSA ATPAF2 AVPI1 AXIN1 BAHD1 BARD1 BEX2 BMS1P1 BRME1 BYSL C10orf62 C11orf87 C19orf73 C1orf216 C22orf46P C2orf68 C8orf48 CA6 CARD9 CATIP CATSPERT CBX8 CCDC112 CCDC116 CCDC120 CCDC146 CCDC185 CCDC198 CCDC26 CCDC93 CCER1 CCNG1 CD33 CDC20B CDK18 CDK5R1 CELA2B CEP57 CEP57L1 CFAP206 CHCHD2 CHCHD3 CHIC2 CLEC18A CNNM3 CNTF COL8A1 COMT COX5A CREB5 CRY2 CTSZ CWF19L2 CYCS CYTH4 DAAM2 DCDC2B DCX DDX6 DHX57 DLGAP2 DMRT3 DOCK2 DOCK8 DTNB EIF4E2 ELOA ENKD1 EXOC3-AS1 FADS2 FAM107A FAM124B FAM27E3 FAM74A4 FAM90A1 FARS2 FASLG FBF1 FBXL18 FBXO34 FBXW5 FEZF1 FKBP1B FNDC11 FOXB1 FRG1 GAD1 GADD45GIP1 GARIN6 GATA2 GATAD2A GEM GFOD1 GGN GLIDR GNAI2 GNE GNG5 GOLGA6L2 GPATCH2L GTF3C5 GUCD1 HAPLN2 HAUS1 HBA2 HBZ HCK HDAC4 HGS HNRNPLL HOXA1 HOXB9 HOXC8 HSD3B7 HSF4 HSPA12B HSPD1 ING5 INO80B INPP5D IQUB ISCU ITGB4 ITGB5 JOSD1 KANK2 KAT5 KCTD9 KDM1A KIFC3 KLHL38 KPNA2 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT78 KRT79 KRT8 KRT81 KRT82 KRT83 KRT85 KRT86 LAGE3 LCE3E LENG1 LHX4 LIMS2 LIN37 LINC00636 LINC01588 LMF2 LMO1 LMO2 LMO4 LNX1 LRCH4 MAB21L2 MAGOHB MAPKBP1 MARK4 MED8 METTL17 MFAP1 MID2 MOB3C MOBP MOS MRPL11 MRRF MSRB3 MTA1 MXI1 MYPOP NAB2 NAPRT NEK6 NFKBID NINJ1 NOL4L-DT NPBWR2 NPPB NR1D2 NXF1 ODAD4 OIP5 OPCML OTUB2 PDLIM5 PEX39 PGLS PHF1 PHF21A PHLDA1 PIGS PIMREG PIN1 PKD2 POLDIP3 POLL POM121L8P POP5 PPP1R18 PRAM1 PRKAA1 PRKAB2 PRPF18 PRPF31 PSMA1 PSMB1 PSMC5 PTGER3 PTPMT1 PXMP2 QPRT RAB3IL1 RAB3IP RAC1 RASSF5 RBM41 RCOR3 RECK RGS8 RNF213 RNF6 RPL11 RSPH14 RTP5 RWDD2B RXRB SCAND1 SCNM1 SCOC SEMA4C SETD5 SH2D4A SHC3 SHFL SIRPA SLC23A1 SLC25A10 SLC35D4 SLIRP SLU7 SMARCE1 SMCO4 SNAI1 SNHG11 SNRPB SNW1 SPATA24 SPATA31J1 SPATC1L SPEF1 SPG7 SPMIP2 SRSF2 SSX2 SSX2IP SUOX SYT6 TACO1 TAPBPL TBC1D16 TBC1D21 TBC1D22B TCEA2 TCEANC TCHP TEAD4 THAP7 TIE1 TLE5 TMEM231 TMSB4X TNIP3 TNNT1 TRIM42 TROAP TRPV6 TSC22D4 TSGA10IP TSHZ3 TTC23 TTC9C TTLL10 TXLNA TXN2 TXNDC5 TYK2 TYRO3 UACA UBASH3A UCMA USHBP1 USP2 USP21 UTP14C UTP23 UXT VEZF1 WDR25 WT1 WT1-AS ZBTB16 ZBTB24 ZBTB38 ZBTB42 ZC2HC1C ZFHX3 ZFP1 ZFP2 ZFP69B ZFYVE21 ZFYVE26 ZGPAT ZMAT2 ZNF101 ZNF124 ZNF138 ZNF165 ZNF17 ZNF20 ZNF202 ZNF230 ZNF250 ZNF26 ZNF266 ZNF286A ZNF317 ZNF319 ZNF329 ZNF337 ZNF408 ZNF410 ZNF417 ZNF438 ZNF439 ZNF446 ZNF488 ZNF490 ZNF564 ZNF569 ZNF575 ZNF580 ZNF581 ZNF587 ZNF625 ZNF655 ZNF688 ZNF697 ZNF702P ZNF76 ZNF792 ZNF844 ZNRF2P1 ZSCAN21	42 interacting genes: APP ATM CCNDBP1 CDK1 CDK2 CMTM5 FAM9B FSD2 GOLGA6L9 HMBOX1 HUWE1 KRT16 KRT19 KRT27 KRT40 KRTAP10-3 KRTAP10-7 LCN2 LDOC1 MAGEA12 MAGEA2 MAGEA2B MAL2 MCC MDFI PCNA PICK1 PNMA1 PRKD3 REV1 RPA1 SSX2IP TFCP2 TFIP11 TNFRSF10D TRIM23 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H ZRANB1
Entrez ID		125115	27343
HPRD ID		08304	09394
Ensembl ID		ENSG00000204889	ENSG00000166169
Uniprot IDs		G3V1C2 Q6A162	A8K860 B4DE17 Q5JQP8 Q9UGP5
PDB IDs			1NZP 1RZT 1XSL 1XSN 1XSP 2BCQ 2BCR 2BCS 2BCU 2BCV 2GWS 2JW5 2PFN 2PFO 2PFP 2PFQ 3C5F 3C5G 3HW8 3HWT 3HX0 3MDA 3MDC 3MGH 3MGI 3PML 3PMN 3PNC 3UPQ 3UQ0 3UQ2 4FO6 4K4G 4K4H 4K4I 4X5V 4XA5 4XQ8 4XRH 4XUS 5CA7 5CB1 5CHG 5CJ7 5CP2 5CR0 5CWR 5DDM 5DDY 5DKW 5III 5IIJ 5IIK 5IIL 5IIM 5IIN 5IIO 5W4G 7M07 7M08 7M09 7M0A 7M0B 7M0C 7M0D 7M0E 7M43 7M44 7M45 7M46 7M47 7M48 7M49 7M4A 7M4B 7M4C 7M4D 7M4E 7M4F 7M4G 7M4H 7M4I 7M4J 7M4K 7M4L 7UN7 8U0O
Enriched GO Terms of Interacting Partners?		Protein Binding Structural Constituent Of Skin Epidermis Keratin Filament Keratinization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Zinc Ion Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Supramolecular Fiber Organization RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleus Metal Ion Binding DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Speck Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Carbon Dioxide Transport	Ubiquitin Conjugating Enzyme Activity Telomere Maintenance Chromosome, Telomeric Region Keratin Filament Protein K48-linked Ubiquitination Telomere Organization Ubiquitin-protein Transferase Activity DNA Biosynthetic Process Intermediate Filament Post-translational Protein Modification Protein Polyubiquitination Nucleus DNA Metabolic Process Protein Monoubiquitination Structural Constituent Of Skin Epidermis Cellular Senescence Cyclin-dependent Protein Kinase Activity Chromosome Organization DNA Repair DNA Replication Intermediate Filament Organization Protein Localization To Site Of Double-strand Break Negative Regulation Of Protein Acetylation Negative Regulation Of Transcription By RNA Polymerase II Protein Modification Process Histone Kinase Activity Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process DNA Damage Response Protein Ubiquitination Protection From Non-homologous End Joining At Telomere Cellular Response To Reactive Oxygen Species Positive Regulation Of DNA Replication Positive Regulation Of Protein Ubiquitination PML Body Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Cellular Response To X-ray Negative Regulation Of Protein Sumoylation Male Germ Cell Nucleus Positive Regulation Of Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Epithelial Cell Differentiation Modification-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Binding DNA Strand Resection Involved In Replication Fork Processing Telomere Maintenance In Response To DNA Damage
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