KRT40 and CNTF

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KRT40	CNTF
Gene Name		keratin 40, type I	ciliary neurotrophic factor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intermediate Filament	Extracellular Space Cytoplasm CRLF-CLCF1 Complex
	Molecular Function	Structural Molecule Activity	Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Growth Factor Activity
	Biological Process		Signal Transduction Positive Regulation Of Cell Proliferation Growth Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Retinal Cell Programmed Cell Death Muscle Organ Morphogenesis Neuron Development Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		313 interactors: ADAMTSL3 AEN AES AKAP17A ALDH3B1 ALS2CR11 ANKRD36BP1 AP1M1 AQP1 AQP5 ARID5A ARMC7 ARSI ASMTL ATPAF2 AVPI1 BAHD1 BARD1 BCAS2 BEX2 BMS1P5 BYSL C10orf62 C11orf87 C14orf105 C19orf57 C19orf66 C19orf73 C1orf109 C1orf216 C20orf195 C22orf46 C5orf60 C6orf165 C6orf226 C8orf48 CA6 CARD9 CATIP CBX8 CCDC112 CCDC120 CCDC146 CCDC185 CCDC26 CCDC93 CCER1 CCHCR1 CCNG1 CD33 CDC20B CDK18 CDK5R1 CELA2B CEP57 CEP57L1 CHCHD2 CHCHD3 CHIC2 CLEC18A CNTF COL8A1 COMT COX5A CREB5 CTSZ CWF19L2 CYCS CYTH4 DAAM2 DCDC2B DCX DDX6 DLGAP2 DMRT3 DOCK2 DOCK8 DTNB EIF4E2 EXOC3-AS1 FAM107A FAM124B FAM214A FAM27E3 FAM64A FAM71C FAM74A4 FAM90A1 FARS2 FASLG FBF1 FBXL18 FBXO34 FBXW5 FKBP1B FOXB1 FRG1 GATA2 GATAD2A GEM GFOD1 GGN GLIDR GNAI2 GNG5 GOLGA6L2 GPATCH2L GTF3C5 GUCD1 HAUS1 HBA2 HBZ HCK HDAC4 HGS HOXA1 HSPA12B HSPD1 ING5 INPP5D IQUB ISCU ITGB5 JOSD1 KAT5 KCTD9 KIFC3 KLHL38 KPNA2 KRT2 KRT20 KRT4 KRT5 KRT6A KRT6C KRT71 KRT72 KRT8 KRT81 LAGE3 LCE3E LENG1 LIMS2 LIN37 LINC00636 LINC01588 LMF2 LMO1 LMO2 LMO4 LOC149950 LRCH4 MAB21L2 MAGOHB MAPKBP1 MARK4 MED8 METTL17 MFAP1 MOB3C MOS MRPL11 MTA1 MXI1 NAB2 NAPRT NDEL1 NEK6 NFKBID NINJ1 NPBWR2 NPPB NR1D2 NXF1 OPCML OTUB2 PDLIM5 PGLS PHF21A PIGS PIN1 PKD2 POLDIP3 POLL POM121L8P POP5 PPP1R18 PRAM1 PRKAA1 PRKAB2 PRPF31 PSMA1 PSMC5 PTGER3 PTPMT1 PXMP2 QPRT RAB3IL1 RAB3IP RAC1 RASSF5 RBM41 RCOR3 RECK RNF213 RPL11 RSPH14 RTP5 RWDD2B SCOC SEMA4C SETD5 SH2D4A SHC3 SIRPA SLC25A10 SLIRP SLU7 SMARCE1 SMCO4 SNAI1 SNHG11 SNRPB SNW1 SPATA24 SPEF1 SPG7 SRSF2 SSX2 SSX2IP SYT6 TAPBPL TBC1D16 TBC1D22B TCEA2 TCEB3 TCHP THAP7 TIE1 TMEM231 TMEM241 TMSB4X TNIP3 TNNT1 TRAF4 TRIM42 TROAP TRPV6 TSC22D4 TSGA10IP TSHZ3 TTC23 TTC25 TTLL10 TXLNA TXN2 TXNDC5 TYK2 TYRO3 UACA UBASH3A UCMA USHBP1 USP2 USP21 UTP14C UTP23 UXT WDR25 WT1 WT1-AS ZBTB16 ZBTB24 ZBTB38 ZC2HC1C ZFHX3 ZFP2 ZFP69B ZFYVE21 ZFYVE26 ZGPAT ZMAT2 ZNF101 ZNF124 ZNF138 ZNF165 ZNF20 ZNF202 ZNF230 ZNF250 ZNF26 ZNF266 ZNF286A ZNF317 ZNF329 ZNF337 ZNF417 ZNF439 ZNF446 ZNF488 ZNF490 ZNF564 ZNF569 ZNF581 ZNF587 ZNF625 ZNF655 ZNF697 ZNF702P ZNF792 ZNF844 ZNRF2P1 ZSCAN21	7 interactors: APOE CNTFR IL6R IL6ST KRT40 LIFR TRIP6
Entrez ID		125115	1270
HPRD ID		08304	00347
Ensembl ID		ENSG00000204889	ENSG00000242689
Uniprot IDs		Q6A162	P26441
PDB IDs			1CNT
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Defense Response To Virus By Virus Regulation Of Cell Death Regulation Of Protein Metabolic Process Anatomical Structure Development Regulation Of Apoptotic Process Bicarbonate Transport Cell Death Death Centrosome Organization Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Intermediate Filament Cytoskeleton Organization Cytoskeleton Organization Microtubule Organizing Center Organization Positive Regulation Of Cellular Protein Metabolic Process Intermediate Filament-based Process Organelle Organization Multicellular Organismal Development	Ciliary Neurotrophic Factor-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Interleukin-6-mediated Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Cellular Response To Organic Substance Positive Regulation Of Cell Proliferation Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Interleukin-6 Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Organic Substance Positive Regulation Of JAK-STAT Cascade Signal Transduction Positive Regulation Of Osteoblast Differentiation Signaling Cell Communication Regulation Of JAK-STAT Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Interleukin-11-mediated Signaling Pathway Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Ossification Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of Osteoblast Differentiation Regulation Of Locomotion Regulation Of Cellular Component Movement Cellular Response To Stimulus Hepatic Immune Response Positive Regulation Of Neurofibrillary Tangle Assembly Interleukin-27-mediated Signaling Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phospholipid Efflux Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Postsynaptic Membrane Organization
Tagcloud ?			cascades cg ciliary compares converge defines deprived evident extensively feel glia hematopoiesis increasingly jak jak1 neurotrophic ol oligodendrocyte oligodendroglia oligodendroglial pdgf pleiotropic progenitor progenitors responded stat stat1alpha stats trophic
Tagcloud (Difference) ?			cascades cg ciliary compares converge defines deprived evident extensively feel glia hematopoiesis increasingly jak jak1 neurotrophic ol oligodendrocyte oligodendroglia oligodendroglial pdgf pleiotropic progenitor progenitors responded stat stat1alpha stats trophic
Tagcloud (Intersection) ?