KRT40 and NPPB

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KRT40	NPPB
Description		keratin 40	natriuretic peptide B
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Intermediate Filament Keratin Filament	Extracellular Region Extracellular Space Cytoplasm Protein-containing Complex
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	Signaling Receptor Binding Hormone Activity Protein Binding Diuretic Hormone Activity Guanylate Cyclase Activator Activity Hormone Receptor Binding
	Biological Process	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Intermediate Filament Organization	System Process Negative Regulation Of Systemic Arterial Blood Pressure Cardiac Conduction System Development CGMP Biosynthetic Process Protein Folding Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Killing Of Cells Of Another Organism Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Regulation Of Vascular Permeability Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance
Pathways		Keratinization Formation of the cornified envelope
Drugs			Carvedilol Oxymetholone
Diseases
GWAS		Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223)	B-type natriuretic peptide levels ( 25561047 29237677) B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio ( 29237677) Blood pressure ( 21909110) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Diastolic blood pressure ( 27618452 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip index ( 34021172) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) N-terminal pro B-type natriuretic peptide levels ( 29237677) NT-proBNP levels in acute coronary syndrome ( 26908625) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 28739976 27618452 27618447 19430483) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)
Interacting Genes		385 interacting genes: ACSF3 ADAMTS1 ADAMTSL3 AEN AGXT AIRIM AKAP17A ALDH3B1 ANKRD36BP1 AP1M1 AQP1 AQP5 ARID5A ARMC7 ARSI ASMTL ATOSA ATPAF2 AVPI1 AXIN1 BAHD1 BARD1 BEX2 BMS1P1 BRME1 BYSL C10orf62 C11orf87 C19orf73 C1orf216 C22orf46P C2orf68 C8orf48 CA6 CARD9 CATIP CATSPERT CBX8 CCDC112 CCDC116 CCDC120 CCDC146 CCDC185 CCDC198 CCDC26 CCDC93 CCER1 CCNG1 CD33 CDC20B CDK18 CDK5R1 CELA2B CEP57 CEP57L1 CFAP206 CHCHD2 CHCHD3 CHIC2 CLEC18A CNNM3 CNTF COL8A1 COMT COX5A CREB5 CRY2 CTSZ CWF19L2 CYCS CYTH4 DAAM2 DCDC2B DCX DDX6 DHX57 DLGAP2 DMRT3 DOCK2 DOCK8 DTNB EIF4E2 ELOA ENKD1 EXOC3-AS1 FADS2 FAM107A FAM124B FAM27E3 FAM74A4 FAM90A1 FARS2 FASLG FBF1 FBXL18 FBXO34 FBXW5 FEZF1 FKBP1B FNDC11 FOXB1 FRG1 GAD1 GADD45GIP1 GARIN6 GATA2 GATAD2A GEM GFOD1 GGN GLIDR GNAI2 GNE GNG5 GOLGA6L2 GPATCH2L GTF3C5 GUCD1 HAPLN2 HAUS1 HBA2 HBZ HCK HDAC4 HGS HNRNPLL HOXA1 HOXB9 HOXC8 HSD3B7 HSF4 HSPA12B HSPD1 ING5 INO80B INPP5D IQUB ISCU ITGB4 ITGB5 JOSD1 KANK2 KAT5 KCTD9 KDM1A KIFC3 KLHL38 KPNA2 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT78 KRT79 KRT8 KRT81 KRT82 KRT83 KRT85 KRT86 LAGE3 LCE3E LENG1 LHX4 LIMS2 LIN37 LINC00636 LINC01588 LMF2 LMO1 LMO2 LMO4 LNX1 LRCH4 MAB21L2 MAGOHB MAPKBP1 MARK4 MED8 METTL17 MFAP1 MID2 MOB3C MOBP MOS MRPL11 MRRF MSRB3 MTA1 MXI1 MYPOP NAB2 NAPRT NEK6 NFKBID NINJ1 NOL4L-DT NPBWR2 NPPB NR1D2 NXF1 ODAD4 OIP5 OPCML OTUB2 PDLIM5 PEX39 PGLS PHF1 PHF21A PHLDA1 PIGS PIMREG PIN1 PKD2 POLDIP3 POLL POM121L8P POP5 PPP1R18 PRAM1 PRKAA1 PRKAB2 PRPF18 PRPF31 PSMA1 PSMB1 PSMC5 PTGER3 PTPMT1 PXMP2 QPRT RAB3IL1 RAB3IP RAC1 RASSF5 RBM41 RCOR3 RECK RGS8 RNF213 RNF6 RPL11 RSPH14 RTP5 RWDD2B RXRB SCAND1 SCNM1 SCOC SEMA4C SETD5 SH2D4A SHC3 SHFL SIRPA SLC23A1 SLC25A10 SLC35D4 SLIRP SLU7 SMARCE1 SMCO4 SNAI1 SNHG11 SNRPB SNW1 SPATA24 SPATA31J1 SPATC1L SPEF1 SPG7 SPMIP2 SRSF2 SSX2 SSX2IP SUOX SYT6 TACO1 TAPBPL TBC1D16 TBC1D21 TBC1D22B TCEA2 TCEANC TCHP TEAD4 THAP7 TIE1 TLE5 TMEM231 TMSB4X TNIP3 TNNT1 TRIM42 TROAP TRPV6 TSC22D4 TSGA10IP TSHZ3 TTC23 TTC9C TTLL10 TXLNA TXN2 TXNDC5 TYK2 TYRO3 UACA UBASH3A UCMA USHBP1 USP2 USP21 UTP14C UTP23 UXT VEZF1 WDR25 WT1 WT1-AS ZBTB16 ZBTB24 ZBTB38 ZBTB42 ZC2HC1C ZFHX3 ZFP1 ZFP2 ZFP69B ZFYVE21 ZFYVE26 ZGPAT ZMAT2 ZNF101 ZNF124 ZNF138 ZNF165 ZNF17 ZNF20 ZNF202 ZNF230 ZNF250 ZNF26 ZNF266 ZNF286A ZNF317 ZNF319 ZNF329 ZNF337 ZNF408 ZNF410 ZNF417 ZNF438 ZNF439 ZNF446 ZNF488 ZNF490 ZNF564 ZNF569 ZNF575 ZNF580 ZNF581 ZNF587 ZNF625 ZNF655 ZNF688 ZNF697 ZNF702P ZNF76 ZNF792 ZNF844 ZNRF2P1 ZSCAN21	13 interacting genes: CYSRT1 EWSR1 GEMIN4 HDAC4 KRT40 KRTAP10-3 KRTAP10-9 NOTCH2NLA NPR1 NPR2 NPR3 PSMA3 SERTAD3
Entrez ID		125115	4879
HPRD ID		08304	08974
Ensembl ID		ENSG00000204889	ENSG00000120937
Uniprot IDs		G3V1C2 Q6A162	P16860
PDB IDs			1YK1 3N56
Enriched GO Terms of Interacting Partners?		Protein Binding Structural Constituent Of Skin Epidermis Keratin Filament Keratinization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Zinc Ion Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Supramolecular Fiber Organization RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleus Metal Ion Binding DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Speck Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Carbon Dioxide Transport	Natriuretic Peptide Receptor Activity CGMP Biosynthetic Process Hormone Binding CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Peptide Hormone Binding Cyclic Purine Nucleotide Metabolic Process Guanylate Cyclase Activity Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Urine Volume Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Keratin Filament Phosphorus-oxygen Lyase Activity Regulation Of Urine Volume Purine Ribonucleotide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase I Neuronal Action Potential Ribose Phosphate Biosynthetic Process Intermediate Filament Regulation Of Cell Growth Negative Regulation Of Cell Growth Regulation Of Blood Pressure Purine Nucleotide Biosynthetic Process G Protein-coupled Peptide Receptor Activity Regulation Of Myotube Differentiation Regulation Of Transcription By RNA Polymerase I Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Blood Circulation Nucleotide Biosynthetic Process ANPR-A Receptor Complex Vestibulocochlear Nerve Maturation Blood Vessel Remodeling D-glucose:proton Symporter Activity Galactose:proton Symporter Activity Regulation Of Glycolytic Process Negative Regulation Of Growth Purine-containing Compound Biosynthetic Process Cajal Body Regulation Of Locomotor Rhythm Regulation Of Carbohydrate Catabolic Process TFIIIC-class Transcription Factor Complex Binding Cumulus Cell Differentiation C-di-GMP Signaling Activation Of Meiosis Involved In Egg Activation Gastric Emptying Sucrose Transport Sucrose:proton Symporter Activity Nucleobase-containing Small Molecule Metabolic Process Regulation Of ATP Metabolic Process
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