ADH1B and IRAK3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ADH1B	IRAK3
Gene Name		alcohol dehydrogenase 1B (class I), beta polypeptide	interleukin-1 receptor-associated kinase 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Interleukin-1 Receptor Complex
	Molecular Function	Alcohol Dehydrogenase Activity, Zinc-dependent Zinc Ion Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Ethanol Oxidation Xenobiotic Metabolic Process Small Molecule Metabolic Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Complex Disassembly Regulation Of Protein Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAP Kinase Activity Negative Regulation Of Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Response To Interleukin-1
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Ethanol oxidation Metabolic disorders of biological oxidation enzymes Defective CYP1B1 causes Glaucoma Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Biological oxidations	Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Cytokine Signaling in Immune system Interleukin-1 signaling Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System
Drugs		NADH Ethanol Fomepizole Nicotinamide-Adenine-Dinucleotide N-Benzylformamide 4-Iodopyrazole 2\'-Monophosphoadenosine 5\'-Diphosphoribose Cyclohexanol Glycerol N-Heptylformamide
Diseases
GWAS		Alcohol consumption ( 23743675) Alcohol dependence ( 23456092 22004471) Esophageal cancer ( 19698717) Esophageal cancer (alcohol interaction) ( 22960999) Upper aerodigestive tract cancers ( 21437268)
Protein-Protein Interactions		5 interactors: GNB2L1 IRAK3 PDE4DIP PML SERPINA3	17 interactors: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6
Entrez ID		125	11213
HPRD ID		00065	05123
Ensembl ID			ENSG00000090376
Uniprot IDs		A8MYN5 P00325	Q9Y616
PDB IDs		1DEH 1HDX 1HDY 1HDZ 1HSZ 1HTB 1U3U 1U3V 3HUD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Regulation Of Endopeptidase Activity Regulation Of Protein Catabolic Process Regulation Of Peptidase Activity Negative Regulation Of Translation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Translation In Response To Oxidative Stress Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Protein Catabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Endopeptidase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Peptidase Activity Positive Regulation Of CAMP Catabolic Process Negative Regulation Of Cell Growth Regulation Of Ion Homeostasis Regulation Of Catalytic Activity Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Negative Regulation Of Kinase Activity PML Body Organization Protein Processing Negative Regulation Of Growth Negative Regulation Of Telomere Maintenance Via Telomerase Response To Virus Regulation Of Translation Negative Regulation Of Oxidative Stress-induced Neuron Death Common-partner SMAD Protein Phosphorylation Positive Regulation Of Proteolysis Regulation Of Phosphorylation Rhythmic Process SMAD Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Negative Regulation Of Translation In Response To Stress Negative Regulation Of Protein Phosphorylation	Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 2 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Lipopolysaccharide MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Cellular Response To Lipid Regulation Of Innate Immune Response Response To Lipopolysaccharide Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Molecule Of Bacterial Origin Toll-like Receptor 9 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 JNK Cascade Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Response To Bacterium Positive Regulation Of Intracellular Signal Transduction Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Lipid Regulation Of Immune Response Regulation Of Immune System Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of MAPK Activity Lipopolysaccharide-mediated Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Immune Response Response To Cytokine Response To Other Organism Response To Biotic Stimulus Cellular Response To Interleukin-1 Inflammatory Response Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Intracellular Signal Transduction
Tagcloud ?		acetaldehyde acetate alcohol alcoholism aldehyde aldh aldh2 allelotypes asians aucs carrying causal combinatorial dehydrogenase east ethanol facial flushing fsbf genotypic han heterozygotes homozygotes ingesting peak pulse resultant	a20 acutely antiphospholipid anx2 aps attenuate chronically explored finger firstly glycoprotein gpi irak1 irak4 iraks lentiviruses leukaemia lv md monocytic paclitaxel rnai tf thp tlr4 toll traf4 traf6 trafs
Tagcloud (Difference) ?		acetaldehyde acetate alcohol alcoholism aldehyde aldh aldh2 allelotypes asians aucs carrying causal combinatorial dehydrogenase east ethanol facial flushing fsbf genotypic han heterozygotes homozygotes ingesting peak pulse resultant	a20 acutely antiphospholipid anx2 aps attenuate chronically explored finger firstly glycoprotein gpi irak1 irak4 iraks lentiviruses leukaemia lv md monocytic paclitaxel rnai tf thp tlr4 toll traf4 traf6 trafs
Tagcloud (Intersection) ?